Non-infectious pulmonary complications after allogeneic stem cells transplantation
YU.A. LERCHENDORPH, W.M. DELYAGIN, E.V. SKOROBOGATOVA, D.N. BALASCHOV, YU.V. SKVORTSOVA, A.A. DEMUSHKINA
Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology named after D. Rogachev of the Ministry of Health of the Russian Federation
Russian Regional Children’s Hospital of the Ministry of Health of the Russian Federation
Lerchendorph Yulia Aleksandrovna
post-graduate student, physician of the Department of functional diagnostics of Federal Research and Clinical Center of Pediatric Hematology, Oncology and Immunology
1 samory Mashela str., Moscow 117997
tel. (495) 287-65-70, е-mail: Yuliya.Lerhendorf@fccho-moscow.ru
The article gives an analysis of non-infectious pulmonary complications of allogeneic hematopoetic stem cells transplantation, which are found in the vast majority of recipients and are classified as early (within the first 100 days after transplantation) and late. The early non-infectious complications are mucositis, pulmonary edema, diffuse bleeding in the lung, and some others. Both in early and late terms after transplantation may develop idiopathic pneumonia syndrome, graft versus host reaction. As of late complications are recorded bronchiolitis obliterans and venooclusive disease.
Key words: thematopoetic stem cells transplantation, lungs, complications, children.
REFERENCES
1. Hollingsworth C., Frush D., Kurtzburg J., Vinod P. Pediatric Hematopoietic Stem Cell Transplantation and the Role of Imaging // Radiology. ― 2008. ― Vol. 248. ― P. 348-365.
2. Horowitz M. Uses and growth of hematopoietic cell transplantation. In: Appelbaum F., Forman S., Negrin R., Blume K. (Eds). Thomas’ Hematopoietic Cell Transplantation.4th ed. West Sussex, Wiley. ― Blackwell, 2008. ― P. 15-21.
3. Afessa B., Abdulai M., Kremers K. et al. Risk factors and outcome of pulmonary complications after autologous hematopoietic stem cell transplant // Chest. ― 2012. ― Vol. 141. ― P. 442-450.
4. Bacigaluppo A., Chien J., Barrison C., Palvetic S. Late pulmonary complications after allogeneic hematopoietic stem cell transplantation: diagnosis, monitoring, prevention, and treatment // Semin.Hematol. ― 2012. ― Vol. 49. ― P. 15-24.
5. Michelson P., Goyal R., Kurland G. Pulmonary complications of haematopoietic cell transplantation in children //Paediatric Respir. Rev. ― 2007. ― Vol. 8. ― P. 46-61.
6. Stiff P. Mucositis associated with stem cell transplantation: current status and innovative approaches to management // Bone Marrow Transplant. ― 2001. ― Vol. 27. ― (Suppl. 2). ― S3-S11.
7. Sonis S. The pathobiology of mucositis // Nat. Rev. Cancer. ― 2004. ― Vol. 4. ― P. 277-284.
13. Whelan H., Buchmann E., Dhokalia A. et al. Effect of NASA lightemitting diode irradiation on molecular changes for wound healing in diabetic mice // J. Clin. Laser Med. Surg. ― 2003. ― Vol. 21. ― P. 67-74.
8. Cahill R., Spitzer T., Mazumder A. Marrow engraftment and clinical manifestations of capillary leak syndrome // Bone Marrow Transplant. ― 1996. ― Vol. 18. ― P. 177-184.
9. Heggen J., West C., Olson E. et al. Diffuse alveolar hemorrhage in pediatric hematopoietic cell transplant patients // Pediatrics. ― 2002. ― Vol. 109. ― P. 965-971.
10. Trobaugh-Lotrario A., Greffe B., Deterding R. et al. Pulmonary venoocclusive disease after autologous bone marrow transplant in a child with stage IV neuroblastoma: case report and literature review // J. Pediatr. Hematol. Oncol. ― 2003. ― Vol. 25. ― P. 405-409.
11. Zhu E., Hu J., Zhang T. et al. Incidence, risks, and outcome of idiopathic pneumonia syndrome early after allogeneic hematopoietic stem cell transplantation // Eur. J. Haematol. ― 2008. ― Vol. 81. ― P. 461-466.
12. Keates-Baleeiro J., Moore P., Koyama T. et al. Incidence and outcome of idiopathic pneumonia syndrome in pediatric stem cell transplant recipients // Bone Marrow Transplant. ― 2006. ― Vol. 38. ― P. 285-289.
13. Au K., Au A., Chien J. Bronchiolitis obliterans syndrome epidemiology after allogeneic hematopoietic cell transplantation // Biol. Blood Marrow Transplant. ― 2011. ― Vol. 17. ― P. 1072-1078.
14. Dudek A., Mahaseth H., DeFor T., Weisdorf D. Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes // Biol. Blood Marrow Transplant. ― 2003. ― Vol. 9. ― P. 657-666.
15. Patriarca F., Poletti V., Costabel U. et al. Clinical presentation, outcome and risk factors of late-onset non-infectious pulmonary complications after allogeneic stem cell transplantation // Curr. Stem Cell Res. Ther. ― 2009. ― Vol. 4. ― P. 161-167.
16. Kurland G., Michelson P. Bronchiolitis obliterans in children // Pediatr. Pulmonol. ― 2005. ― Vol. 39. ― P. 193-208.
17. Santo Tomas L., Loberiza F., Klein J. et al. Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia // Chest. ― 2005. ― Vol. 128. ― P. 153-161.
18. Marras T., Chan C. Obliterativebronchiolitis complicating bone marrow transplantation // Semin. Respir. and Crit. Care Medicine. ― 2003. ― Vol. 24. ― P. 531-542.
19. Lemonnier F., Dhedin N., Catherinot E. et al. Bronchiolitis obliteranspostallogeneic stem cell transplantation: what is new? // Rev. Pneumol. Clin. ― 2011. ― Vol. 67. ― P. 258-266.
20. Sanchez J., Torres A., Serrano J. et al. Long-term follow-up of immunosuppressive treatment for obstructive airways disease after allogeneic bone marrow transplantation // Bone Marrow Transplant. ― 1997. ― Vol. 20. ― P. 403-408.
21. Fullmer J., Fan L., Dishop M. et al. Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade // Pediatrics. ― 2005. ― Vol. 116. ― P. 767-770.
22. Khalid M., Saghir A., Saleemi S. et al. Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study // Eur. Respir. J. ― 2005. ― Vol. 25. ― P. 490-493.
23. Lynch D., Travis W., Muller N. et al. Idiopathic interstitial pneumonias: CT features // Radiol. ― 2005. ― Vol. 236. ― P. 10-21.
24. Hayes-Jordan A., Benaim E., Richardson S. et al. Open lung biopsy in pediatric bone marrow transplant patients // J. Pediatr. Surg. ― 2002. ― Vol. 37. ― P. 446-452.
25. Ratjen F., Rjabko O., Kremens B. High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children // Bone Marrow Transplant. ― 2005. ― Vol. 36. ― P. 135-138.
26. Marras T., Chan C., Lipton J. et al. Long-term pulmonary function abnormalities and survival after allogeneic marrow transplantation // Bone Marrow Transplant. ― 2004. ― Vol. 33. ― P. 509-517.
27. Wilczynski S., Erasmus J., Petros W. et al. Delayed pulmonary toxicity syndrome following high-dose chemotherapy and bone marrow transplantation for breast cancer // Am. J. Respir.& Crit. Care Med. ― 1998. ― Vol. 157. ― P. 565-573.
28. Gosselin M., Adams R. Pulmonary complications in bone marrow transplantation // J. Thorac. Imaging. ― 2002. ― Vol. 17. ― P. 132-144.
29. Trobaugh-Lotrario A., Greffe B., Deterding R. et al. Pulmonary venoocclusive disease after autologous bone marrow transplant in a child with stage IV neuroblastoma: case report and literature review // J. Pediatr. Hematol. Oncol. ― 2003. ― Vol. 25. ― P. 405-409.
30. Wolff D., Reichenberger F., Steiner B. et al. Progressive interstitial fibrosis of the lung in sclerodermoid chronic graft-versus-host disease // Bone Marrow Transplant. ― 2002. ― Vol. 29. ― P. 357-360.