K.A. TUPIKIN, Yu.A. KOVALENKO, A.A. OLIPHIR, M.D. BAYDAROVA, V.A. VISHNEVSKY

Institute for Surgery named after A.V. Vishnevskiy, 27 Bolshaya Serpukhovskaya Str., Moscow, Russian Federation, 117997

Tupikin K.A. ― postgraduate student of the Department of Abdominal Surgery №2, tel. (499) 236-53-42, e-mail: tpkir-nv@yandex.ru

Kovalenko Yu.A. ― Cand. Med. Sc., senior researcher of the Department of Abdominal Surgery №2, tel. (499) 236-53-42, e-mail: Kovalenko@ixv.ru

Oliphir A.A. ― resident physician, tel. (499) 236-53-42, e-mail: vatlat@yandex.ru

Baydarova M.D. ― resident physician, tel. (499) 236-53-42, e-mail:marinabaidarova@gmail.com

Vishnevsky V.A. ― D. Med. Sc., Professor, Head of the Department of Abdominal Surgery №2, tel. (499) 237-80-54, e-mail: VishnevskyVA@ixv.ru

Based on the analysis of liver resections in 247 patients a diagnostically meaningful set of indicators is determined, a linear predictive multivariable point scale is created, a formula of prognostic index for calculating the probability of liver failure in the first 4-6 hours after surgery is derived. Depending on the calculated values of the criterion, the probability of different classes of liver failure is determined. Creating prediction systems can rationally distribute the available means of treatment and prophylaxis of post-resection liver failure.

Key words: postresection liver failure, prediction, prognostic score.

REFERENCES

1. Vishnevskiy V.A., Kovalenko Yu.A., Andreytseva O.I. et al. Post-resection liver failure: modern problems of definition, epidemiology, pathogenesis, risk assessment, prevention and treatment. Ukrainskiy zhurnal khirurgii, 2013, 22 (3), pp. 172-182 (in Russ.).
2. Garcea G., Maddern G.J. Liver failure after major hepatic resection. J. Hepatobiliary Pancreat. Surg, 2009, 16, pp. 145-155.
3. Rahbari N.N., Garden O.J., Padbury R., et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery, 2011, May, 149 (5), pp. 713-724. DOI: 10.1016/j.surg.2010.10.001
4. Balzan S., Belghiti J., Farges O., et al. The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann. Surg, 2005, 242 (6), pp. 824-828.
5. Grąt M., Hołówko W., Lewandowski Z., et al. Early post‐operative prediction of morbidity and mortality after a major liver resection for colorectal metastases. HPB, 2013, 15 (5), pp. 352-358.
6. Li J.1., Lei B., Nie X., et al. A Comprehensive Method for Predicting Fatal Liver Failure of Patients With Liver Cancer Resection. Medicine, 2015, 94 (17), p. e784.