N.A. CHEREPANOV¹, R.S. ZAMALEEVA², L.I. MALTSEVA², A.V. PHRIZINA¹, V.K. LAZAREVA¹, T.R. ZEPHIROVA², M.E. ZHELEZOVA²

¹Volzhsk Central City Hospital, 46 Sovetskaya St., Volzhsk, the Republic of Mari-El, Russian Federation, 425000

²Kazan State Medical Academy, 36 Butlerov St., Kazan, Russian Federation, 420012

Cherepanova N.A. ― Cand. Med. Sc., Head of the Maternity Department, tel. (83631) 6-37-73, e-mail: nat26@list.ru

Zamaleeva R.S. ― D. Med. Sc., Professor of Department of Obstetrics and Gynecology №1, tel. (843) 236-46-41, e-mail: zamaleewa@rambler.ru

Maltseva L.I. ― D. Med. Sc., Professor of Department of Obstetrics and Gynecology №1, tel. (843) 236-46-41, e-mail: laramalc@mail.ru

Frizina A.V. ― obstetrician-gynecologist, tel. (83631) 6-37-73, e-mail: venera-lazareva@mail.ru

Lazareva V.K. ― Competitor of the Department of Obstetrics and Gynecology №1, tel. (83631) 6-37-73, e-mail: venera-lazareva@mail.ru

Zefirova T.P. ― D. Med. Sc., Professor of Department of Obstetrics and Gynecology №1, tel. (843) 236-46-41, e-mail: tzefirova@gmail.com

Zhelezova M.E. ― Cand. Med. Sc., Associate Professor of the Department of Obstetrics and Gynecology №1, tel. (843) 236-46-41, e-mail: gelezovam@gmail.com

There were analyzed values of Pregnancy-associated Plasma Protein-A ― РАРР-А, human chorionic gonadotrophin and pulsation index of uterine arteries in the framework of the first trimester and determination of serum content of 8 regulatory autoantibodies in the first trimester of pregnancy in women at risk with occurrence of fetal growth retardation. The revealed features exclude the feasibility of isolated determination of the first screening markers for the prediction of fetal growth retardation. The inclusion of autoantibodies to insulin, PAPP-A, collagen and summary phospholipides significantly increase the sensitivity and specificity of the forecast and can be used to form a risk group of fetal growth retardation.

Key words: PAPP-A, HCG, pulsation index, fetal growth retardation, autoantibodies.

 

 

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