L.V. PUZYREVA¹, T.G. RUSINOVA², YU.E. GOLOVANOVA², O.V. DVORZHETSKAYA², A.G. PATYUKOV¹, A.YU. KONSTANTINOVA²

 ¹Omsk State Medical University, Omsk

²Regional Clinical Hospital, Omsk

 Contact details:

Puzyreva L.V. — MD, Associate Professor of the Higher Attestation Commission, Head of the Department of Pediatric Infectious Diseases

Address: 12 Lenin St., 644043 Omsk, Russian Federation, tel.: +7-913-149-1232, e-mail: puzirevalv@mail.ru

 Listeriosis is a forgotten but formidable infection for a pregnant woman, fetus and newborn. The clinical picture of the disease depends on the characteristics of the organism. The pregnant woman may experience premature labor, non-viable pregnancy, or miscarriage. For a newborn, Listeria monocytogenes can be fatal. We offer a description of a clinical case of neonatal listeriosis in a premature girl at 32 weeks with deep hypoxia, cerebral ischemia and respiratory distress syndrome. The child was promptly delivered to a specialized department, where treatment was carried out at several stages. Microbiological examination confirmed intrauterine infection of the newborn with Listeria monocytogenes. Positive dynamics in clinical and laboratory data were achieved against the background of antibacterial therapy.

Key words: Listeria monocytogenes; listeriosis; listeriosis in pregnant women, neonatal infection, neonatal listeriosis.

REFERENCES

1. Tyukavkina S.Yu., Kotieva I.M., Dodokhova M.A. et al. Pathogenesis and clinical forms of human listeriosis. Yuzhno-Rossiyskiy zhurnal terapevticheskoy praktiki, 2024, vol. 5, no. 1, pp. 99–111 (in Russ.). DOI: 10.21886/2712-8156-2024-5-1-99-111
2. Nafeev A.A., Modnikova V.I., Popov V.V. et al. On the issue of diagnostics of intrauterine listeriosis. Detskie infektsii, 2022, vol. 21, no. 1, pp. 66–69 (in Russ.). DOI: 10.22627/2072-8107-2022-21-1-66-69
3. Belova A.V., Nikonov A.P., Kaptil’nyy V.A., Naumenko N.S. Listeriosis and pregnancy: current issues of diagnosis, treatment and prevention. Arkhiv akusherstva i ginekologii im. V.F. Snegireva, 2018, vol. 5, no. 4, pp. 187–192 (in Russ.). DOI: 10.18821/2313-8726-2018-5-4-187-192
4. Disson O., Grayo S., Huillet E., et al. Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis. Nature, 2008, vol. 455 (7216), rr. 1114–1118.
5. Charlier C., Perrodeau E., Leclercq A. et al. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis, 2017, vol. 17, rr. 510–519.
6. Vázquez-Boland J.A., Krypotou E., Scortti M. Listeria placental infection. mBio, 2017, vol. 8 (3), e00949-17. DOI: 10.1128/mBio.00949-17 PMID: 28655824
7. Prikaz Ministerstva zdravookhraneniya RF ot 15.11.2012 no. 921n “Ob utverzhdenii Poryadka okazaniya meditsinskoy pomoshchi po profilyu «neonatologiya»”[Order of the Ministry of Health of the Russian Federation dated 15.11.2012 No. 921n «On approval of the Procedure for the provision of medical care in the profile of «neonatology»»], available at: https://base.garant.ru/70293290/?ysclid=m2xf51nvuk634467234
8. Proekt klinicheskikh rekomendatsiy “Sepsis novorozhdennykh” [Draft clinical guidelines «Sepsis in newborns»], 2024. 91 p.
9. Proekt klinicheskikh rekomendatsiy “Infektsiya, spetsifichnaya dlya perinatal’nogo perioda” [Draft clinical guidelines «Infection specific to the perinatal period»], 2024. 63 p.
10. Schlech W.F. Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection. Microbiol Spectr, 2019, vol. 7 (3). DOI: 10.1128/microbiolspec
11. Gahan C.G., Hill C. Listeria monocytogenes: survival and adaptation in the gastrointestinal tract. Front Cell Infect Microbiol, 2014, vol. 4, rr. 9–16. DOI: 10.3389/fcimb.2014.00009
12. Charlier C., Disson O., Lecuit M. Maternal-neonatal listeriosis. Virulence, 2020, vol. 11 (1), rr. 391–397. DOI: 10.1080/21505594.2020.1759287
13. Klimova E.A., Voronina O.L., Karetkina G.N. et al. Listeriosis and the COVID-19 pandemic. Infektsionnye bolezni: novosti, mneniya, obuchenie, 2022, vol. 11, no. 1, pp. 102–112 (in Russ.). DOI: 10.33029/2305-3496-2022-11-1-102-112
14. Maury M.M., Tsai Y.H., Charlier C. et al. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet, 2016, vol. 48 (3), rr. 308–313.
15. Koopmans M.M., Brouwer M.C., Vázquez-Boland J.A., van de Beek D. Human Listeriosis. Clin Microbiol Rev, 2023, vol. 36 (1), e0006019. DOI: 10.1128/cmr.00060-19
16. Wolfe B., Wiepz G.J., Schotzko M. et al. Acute fetal demise with first trimester maternal infection resulting from Listeria monocytogenes in a nonhuman primate model. mBio,2017, vol. 8, e01938-16. DOI: 10.1128/mBio.01938-16
17. Pérez-Trallero E., Zigorraga C., Artieda J. et al. Two outbreaks of Listeria monocytogenes infection, Northern Spain. Emerg Infect Dis, 2014, vol. 20, rr. 2155–2157. DOI: 10.3201/eid2012.140993
18. Wald A., van Thiel D.H., Hoechstetter L. et al. Effect of pregnancy on gastrointestinal transit. Dig Dis Sci, 1982, vol. 27, rr. 1015–1018. DOI: 10.1007/BF01391748
19. Sobyanin K.A., Sysolyatina E.V., Chalenko Ya.M. et al. The role of natural variants of Listeria monocytogenes invasion factors in perinatal listeriosis. Zhurn. mikrobiol, 2018, no. 4, pp. 114-118 (in Russ.).
20. Schuchat A., Lizano C., Broome C.V. et al. Outbreak of neonatal listeriosis associated with mineral oil. Pediatr Infect Dis J, 1991, vol. 10, rr. 183–189. DOI: 10.1097/00006454-199103000-00003
21. Tai Y.L., Chi H., Chiu N.C. et al. Clinical features of neonatal listeriosis in Taiwan: A hospital-based study. J. Microbiol. Immunol. Infect, 2020, vol. 53 (6), pp. 866-874. DOI: 10.1016/j.jmii.2019.08.001