A.S. PALASCHENKO^1,2, I.V. SMAGINA¹, S.A. ELCHANINOVA¹

¹Altai State Medical University, 40 Lenin Str., Barnaul, Russian Federation, 656038

² Regional Clinical Hospital, 1 Lyapidevskogo Str., Barnaul, Russian Federation, 656024

 Palashchenko A.S. ― Assistant of the Department of Psychiatrics, Medical Psychology and Neurology, neurologist, e-mаil: anna.cheremisina.87@mail.ru, ORCID ID: 0000-0001-8743-8803

Smagina I.V. ― D. Sc. (medicine), Professor of the Department of Psychiatrics, Medical Psychology and Neurology, neurologist, e-mаil: siv7000@yаndеx.ru,  ORCID ID: 0000-0002-7947-4529

Elchaninova S.A. ― D. Sc. (biology), Professor of the Department of General and Biological Chemistry and Clinical Laboratory Diagnostics, e-mаil: saеlсh@mail.ru,  ORCID ID: 0000-0003-2730-615X

 Objective ― to assess the association of TNFa (rs1800629, rs361525), TNFRSF1A (rs4149584), СD40 (rs6074022, rs11086998) polymorphisms with the frequency of exacerbation and progression rate of multiple sclerosis.

Material and method. The retrospective study involved 100 patients with relapsing-remitting MS ― Caucasians, born and living in the Altai region (Russia). Genetic typing was implemented according to the TaqMan-probes technology with iСyсler iQ5 amplifier (Biо-Rad, USA).

Results. Association of G/A TNFRSF1A (rs4149584) with a rapid disability progression was statistically significant, while G/G genotype of this polymorphism was associated with slower disability progression. The link between TNFRSF1A (rs4149584) A allele, female sex and increased risk of rapid disability progression was shown. Exacerbation rate correlated positively with TNFa (rs1800629) A allele.

Conclusion. It is promising to use TNFRSF1A (rs4149584) and TNFa (rs1800629) genetic typing data in comprehensive assessment of MS rapid progression risk factors for the optimal treatment selection.

Key words: multiple sclerosis, exacerbation, disability progression, genotype.

(For citation: Palashchenko A.S., Smagina I.V., Elchaninova S.A. Multiple sclerosis course and TNF-a_(rs1800629, rs361525), TNFRSF1А (rs4149584), CD40_(rs6074022, rs11086998) polymorphisms association. Practical Medicine. 2018)

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