N.E. SEKSYAEV, N.V. SELYANINA, I.V. ZAMKOVA, A.V. ZHELNIN, YU.V. KARAKULOVA

 Perm State Medical University named after acad. E.A. Vagner, Perm

Contact details:

Selyanina N.V. — MD, Professor of the Department of Neurology and Medical Genetics

Address: 26 Petropavlovskaya St., 614000 Perm, Russian Federation, tel.: +7-908-250-42-23, e-mail: vnselyanina@mail.ru

Churg — Strauss syndrome (CSS) is an autoimmune disease affecting small and medium-sized vessels and the respiratory tract, accompanied by eosinophilia. The clinical manifestations of CSS are various, making its diagnosis challenging. CSS is characterized by involvement of the nervous system. The presented clinical case demonstrates one variant of the disease progression involving the peripheral nervous system — the rapid development of multiple mononeuropathy associated with eosinophilic granulomatosis with polyangiitis.

Key words: Churg — Strauss syndrome, eosinophilia, multiple mononeuropathy

REFERENCES

1. Nasonov E.L. Rossiyskiye klinicheskiye rekomendatsii. Revmatologiya [Russian Clinical Guidelines. Rheumatology]. Moscow: GEOTAR-Media, 2017, available at: https://medbase.ru/book/ISBN9785970442616.html
2. Kochiyeva M.L. Approaches to the diagnosis of Churg-Strauss syndrome. Spravochnik vracha obshchey praktiki, 2023, no. 5, pp. 50–55 (in Russ.). DOI: 10.33920/med-10-2305-073
3. Adasheva T.V., Nesterenko O.I., Zadionchenko V.S. et al. Clinical case of Churg-Strauss syndrome: diagnostic difficulties, therapeutic tactics. Arkhiv vnutrenney meditsiny, 2016, vol. 6, no. 5 (31), pp. 63–69 (in Russ.). DOI: 10.20514/2226-6704-2016-6-5-63-69
4. Norkina A.S., Zotova L.A., Nikulenkova N.E. Clinical case of late diagnosis of Churg-Strauss disease. Mezhdunarodnyy nauchno-issledovatel′skiy zhurnal, 2019, no. 3, pp. 65–67 (in Russ.). DOI: 4. 10.23670/IRJ.2019.81.3.010
5. Barlamov O.P., Barlamov P.N. Allergic bronchopulmonary aspergillosis (known unknown disease, analysis of clinical observation). Permskiy meditsinskiy zhurnal, 2023, vol. 40, no. 4, pp. 127–134 (in Russ.). DOI: 10.17816/pmj404127%134
6. Murkamilov I.T., Aytbayev K.A., Rayimzhanov Z.R. et al. ANCA-associated vasculitides: focus on eosinophilic granulomatosis with polyangiitis (Churg-Strauss eosinophilic vasculitis). Byulleten′ nauki i praktiki, 2024, vol. 10, no. 2, pp. 203–223 (in Russ.). DOI: 10.33619/2414-2948/99/25
7. Federal′nyye klinicheskiye rekomendatsii po diagnostike i lecheniyu sistemnykh vaskulitov, 2017 [Federal clinical guidelines for the diagnosis and treatment of systemic vasculitides, 2017], available at: https://library.mededtech.ru ru/upload/iblock/b55/sistemnye_vaskulity.pdf?ysclid=mmgckr1f3b928985695 (accessed on: 07.03.2026).
8. Kuznetsova A.S., Mel′nik S.I., Gavrilov P.V. et al. Features of the diagnostic search in Churg-Strauss syndrome. Clinical case. Pediatriya. ConsiliumMedicum, 2023, no. 2, pp. 198–204 (in Russ.). DOI: 10.26442/26586630.2023.2.202314
9. Moiseyev S.V., Novikov P.I., Zagvozdkina E.S. Eosinophilic granulomatosis with polyangiitis (Cherga-Strauss): recommendations for diagnosis and treatment. Klinicheskaya farmakologiya i terapiya, 2016, vol. 25, no. 3, pp. 73–78 (in Russ.).