A.A. SAGDATOVA¹, R.KH. ZULKARNEEV¹, E.K. KHUSNUTDINOVA^{2, 3, A}.KH. NURGALIEVA³, Sh.Z. ZAGIDULLIN¹

 ¹Bashkir State Medical University, 3 Lenin Str., Ufa, Russian Federation, 450000

²Ufa Scientific Center of the Russian Academy of Sciences, Institute of Biochemistry and  Genetics, 71 Prospekt Oktyabrya, Ufa, Russian Federation, 450054

³Bashkir State University, 32 Validi Str., Ufa, Russian Federation, 450076

 Sagdatova A.A. — post-graduate student of the Department of Internal Diseases Propaedeutics, tel. +7-917-77-259-60, e-mail: aliyasg@rambler.ru

Zulkarneev R.Kh. — D. Med. Sc., Professor of the Department of Internal Diseases Propaedeutics, tel. (347) 246-53-97, e-mail:zrustem@ufanet.ru

Khusnutdinova E.K. — D. Biol. Sc., Professor, Head of the Department of Genetics and Fundamental Medicine, Head of the Department of Genomics, Head of the Laboratory of Human Molecular Genetics, tel. (347) 2-299-671, e-mail: biodekanat@yandex.ru

Nurgalieva A.Kh. — Cand. Biol. Sc., Associate Professor of the Department of Genetics and Fundamental Medicine, tel. (347) 2-299-671, e-mail: Alfiyakh83@gmail.com

Zagidullin S.Z. — D. Med. Sc., Professor, Head of the Department of Internal Diseases Propaedeutics, tel. (347) 246-53-97, e-mail: zshamil@inbox.ru

The article presents the results of a study of 195 patients with a diagnosis of cholelithiasis. The relationship was analyzed between clinical laboratory factors, serum lipid spectrum and polymorphic loci rs693 gene APOB-100 and rs4131229 gene ABCG5 using ROС analysis and binary logistic regression. The independent disease development factors were genotype X⁺X^— gene apoB-100 and the following phenotypic characteristics: the body weight over 56kg, leukocytosis > 6*10⁹/L, lipid disorders (HDL≤1,26 mmol/L, LDL> 1.68 mmol/l), conjugated bilirubin> 2,9 mmol/l). The mathematical model of the probability of gallstone disease was built. The diagnostic scale of GD development features was made on the basis of the model.

Key words: cholelithiasis, gene polymorphism of the apolipoprotein B-100, ABCG5, lipoproteins.

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