Morphological and clinical-functional changes in retina in the different treatment methods of endophthalmitis (experimental study)
I.A. FROLYCHEV¹, N.A. POZDEYEVA¹, A.V. SERGEEV²
1Cheboksary branch of the S. Fyodorov Eye Microsurgery Federal State Institution, 10 Prospekt Traktorostroiteley, Cheboksary, Russian Federation, 428028
2Forensic Medical Bureau, 24 Pirogov Str., Cheboksary, Russian Federation, 428000
Frolychev I.A. — Researcher, tel.: (8352) 49-24-13, e-mail: ivan-f@yandex.ru
Pozdeyeva N.A. — D. Med. Sc., Deputy Director on Research, tel. (8352) 36-46-96, e-mail: npozdeeva@mail.ru
Sergeev A.V. — Cand. Med. Sc., Deputy Director for Medical Issues, tel. (8352) 37-85-52, e-mail: sergeevav@rbsme.ru
The article presents the results of experimental work evaluating the safety of various treatment methods of endophthalmitis: intravitreal treatment by antibacterial drugs, vitrectomy, vitrectomy with vitreal cavity tamponade with perfluorodecalin emulsion and solutions of antibacterial drugs for 14 days, vitrectomy with tamponade with silicone oil. Changes in the retina of rabbits’ eyes were evaluated based on data changes of posterior segment OCT, electroretinography and morphological changes in the structure of the cadaver eyes retina. Postoperative inflammation was monitored by laser flare photometry, assessing the flow of protein in the anterior chamber. Postoperative complications were not found in any group. According to laser tindalometry, by 14 days the protein flow in the anterior chamber returned to normal (standard) values in all groups. In the course of the experiment according to electroretinography data, clinical and functional data of toxic effect on the retina were not found in all treatment methods. The changes in the retina thickness are absent, according to the data of posterior segment OCT. According to electroretinography data, the postoperative decrease in the retina function has a functional, temporary nature. The data obtained during the morphological study are confirmed by clinico-functional ones. A small thickening of the nerve fibers layer was revealed in all rabbits where vitrectomy was performed. Morphological changes in the retinas indicate a postoperative eye reaction to vitrectomy, and not to the toxic effect of tamponade substances.
Key words: postoperative endophthalmitis, perfluorodecalin, electroretinography, vitrectomy, intravitreal treatment by antibacterial drugs.
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