A.F. SHAKUROV¹, V.A. ABDULIANOV^1,2, O.Yu. KARPUKHIN^1,3

¹Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation 420012

²Inter-regional Clinical Diagnostic Center, 12a Karbyshev St., Kazan, Russian Federation 420101

³Republican Clinical Hospital of the Ministry of Healthcare of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation 420068 

Shakurov A.F. — postgraduate student of the Department of Surgical Diseases № 1, tel. +7-904-660-11-39, e-mail: aydarsha@yandex.ru¹

Abdulianov V.A. — Cand. Med. Sc., Associate Professor of the Department of Pathology Anatomy, Head of Pathology Anatomy Department of Inter-regional Clinical Diagnnostic Center^1,2

Karpuknin O.Yu. — D. Med. Sc., Professor of the Department of Surgical Diseases № 1, tel. (843) 269-00-53, e-mail: oleg_karpukhin@mail.ru^1,3 

Morphological study of large intestinal surgical specimens of 16 patients with decompensated form of chronic constipation had been performed. In 14 (87,5%) of those colonic form of constipation was diagnosed as a result of anatomical anormality of gut structure or anormality of its location in the abdominal cavity, in 2 (12,5%) – rectal form of constipation – supra-anal form of Hirschsprung’s disease. The study found atrophy of the mucous and muscular membranes, disorder of microcirculation in the intestine wall, chronic inflammation in the submucous and mucous layers, and changes in the structure of intermuscular Auerbach’s nervous plexus. Histopathologic changes in the intestinal wall in the case of Hirschsprung’s disease had specific characteristics. The revealed changes cause inefficiency of conservative treatment of patients with decompensated form of chronic constipation and can serve as an argument in favor of choosing surgical intervention

Key words: decompensated form of chronic constipation, colonic form of constipation syndrome, Hirschsprung’s disease, histopathological study, specific characteristics of histopathologic changes.

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