G.A. GAMIDOV, I.A. MUSHKOVA, S.V. KOSTENEV

1. Fyodorov Eye Microsurgery Federal State Institution, 59a Beskudnikovsky Blvd., Moscow, Russian Federation, 127486

 Contact:

Gamidov G.A. ― postgraduate student of the Department of Refractive Laser Surgery, e-mail: doc.gamidov@gmail.com

Mushkova I.A. ― D. Med. Sc., Head of the Department of Refractive Laser Surgery, tel. (499) 488-87-42, e-mail: i.a.muskova@mail.ru

Kostenev S.V. ― D. Med. Sc., Senior Researcher of the Department of Refractive Laser Surgery, tel. (499) 488-87-61, e- mail: kostenev@mail.ru

 The article is devoted to the review of the latest and most popular modifications of corneal collagen crosslinking (CCCL) in keratoconus treatment, and the results of the main experimental and clinical research published in scientific literature.

Among various corneal ectasias, special attention is paid to keratoconus. Until recently, keratoconus treatment consisted in application of rigid contact lenses at early stages and surgical treatment. Unfortunately, these methods can only eliminate the symptoms of the disease but not stop its progression. The situation has changed with the advent of corneal collagen crosslinking. The crosslinking mechanism consists in the use of Riboflavinum which is irradiated with ultra-violet (UV) light. The impact of UV light on a Riboflavinum molecule produces free radicals which catalyze the reaction leading to formation of covalent links between collagen molecules which results in the cornea strengthening. Due to this, the keratoconus progression slows down or stops.

The procedure is carried out under the standard («Dresden») protocol which implies removal of an epithelium so that Riboflavinum could be absorbed by a cornea stroma. However, this stage causes the undesirable effect in the form of pain and corneal syndrome after the procedure and increases the risk of secondary infection. In this regard, it is relevant to development new methods of Riboflavinum delivery to stroma which would be deprived of shortcomings inherent in the standard technology, but would not concede by efficiency.

Key words: keratoconus, cornea, crosslinking, femtosecond laser.

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