Modern approaches to psychotherapeutic rehabilitation of patients with chronic cardiovascular diseases
G.S. GALYAUTDINOV, A.G. ZHIDYAEVSKIJ, М.К. NESTERINA, А.А. ANDRIANOV
Kazan State Medical University, Kazan
Contact details:
Galyautdinov G.S. — PhD (Medicine), Professor of the Department of Hospital Therapy
Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7 (843) 236-04-11, e-mail: galgen077@mail.ru
The review is devoted to the topical problem of rehabilitation of patients with cardiovascular diseases, which remain the leading cause of morbidity, disability and mortality in Russia and worldwide. A number of works demonstrating a close relationship between the course and prognosis of cardiovascular diseases and the psycho-emotional sphere of patients were analyzed. International and Russian experts emphasized the importance of timely identification and correction of psychosocial risk factors, in particular, depression, anxiety disorders, psychosocial stressors and others. The question of the need for a multidisciplinary approach to the patient in cardiac rehabilitation programs is raised. Emphasis is placed on the expediency of combining psychocorrection, psychotherapy and psychopharmacotherapy to increase the effectiveness of rehabilitation measures. The leading goals of these interventions are to change the internal picture of the disease, to achieve psychosocial adaptation and to improve the quality of life of patients with chronic cardiac diseases. This approach contributes to the prevention of exacerbations, complications and chronicization of somatic pathology, which improves labor prognosis, reduces the risk of disability and early mortality. Thus, the conducted analysis allows forming a holistic view of the importance of specialized psychological and psychotherapeutic care, the existing methods of correction and pharmacotherapy within the framework of rehabilitation measures in patients with cardiac diseases.
Key words: cardiovascular diseases, rehabilitation, psychotherapy, prevention.
REFERENCES
- The top 10 causes of death. Fact sheet., 2020 // World Health Organization: web site, available at: https://www.who.int/ru/news-room/fact-sheets/detail/the-top-10-causes-of-death (accessed on: 03.11.2023).
- Russian Society of Cardiology (RSC). Stable coronary heart disease. Clinical recommendations 2020. Rossiyskiy kardiologicheskiy zhurnal, 2020, vol. 25, no. 11, p. 4076 (in Russ.).
- Muromtseva G.A., Kontsevaya A.V., Konstantinov V.V. et al. Prevalence of risk factors for non-communicable diseases in the Russian population in 2012–2013. Results of the ESSE-RF study. Kardiovaskulyarnaya terapiya i profilaktika, 2014, vol. 13, no. 6, pp. 4–11 (in Russ.).
- Williams B., Mancia G., Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). European heart journal, 2018, vol. 39 (33), pp. 3021–3104.
- Kontsevaya A.V., Mukaneeva D.K., Myrzamatova A.O. et al. Economic damage of risk factors due to their contribution to morbidity and mortality from major chronic non-communicable diseases in the Russian Federation in 2016. Kardiovaskulyarnaya terapiya i profilaktika, 2020, vol. 19, no. 1, pp. 48–55 (in Russ.).
- Shishkova V.N. Strategy for the management and prevention of psycho-emotional disorders in practice. Meditsinskiy sovet, 2023, vol. 17, no. 6, pp. 76–82 (in Russ.).
- Drapkina O.M., Kontsevaya A.V., Kalinina A.M. et al. Prevention of chronic non-infectious diseases in the Russian Federation. National guidelines 2022. Kardiovaskulyarnaya terapiya i profilaktika, 2022, vol. 21, no. 4, p. 3235 (in Russ.).
- Galyautdinov G.S., Mendelevich V.D., Zhidyaevskiy A.G. et al. Psychosocial adaptation of patients to chronic cardiovascular diseases. Vestnik sovremennoy klinicheskoy meditsiny, 2023, vol. 16, no. 1, pp. 80–88 (in Russ.).
- Bubnova M.G. Current problems of participation and training of cardiac patients in cardiac rehabilitation and secondary prevention programs. Kardiovaskulyarnaya terapiya i profilaktika, 2020, vol. 19, no. 6, pp. 101–108 (in Russ.).
- Mikhaylova T.V., Solov’eva S.L., Yugay A.L. Prognostic capabilities of psychosocial factors in chronic heart failure. Dal’nevostochnyy meditsinskiy zhurnal, 2006, no. 4, pp. 11–14 (in Russ.).
- Gromov E.A. Psychosocial risk factors for cardiovascular diseases. Sibirskiy meditsinskiy zhurnal, 2012, no. 2, pp. 22–29 (in Russ.).
- Piepoli M.F., Hoes A.W., Agewall S. et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). European journal of preventive cardiology, 2016, vol. 23 (11), pp. 2315–2381.
- Drapkina O.M., Shishkova V.N., Kotova M.B. Psycho-emotional risk factors for chronic non-infectious diseases in outpatient practice. Methodological recommendations for therapists. Kardiovaskulyarnaya terapiya i profilaktika, 2022, vol. 21, no. 10, pp. 97–117 (in Russ.).
- Rossiyskoe obshchestvo psikhiatrov. Trevozhno-fobicheskie rasstroystva: klinicheskie rekomendatsii [Russian Society of Psychiatrists. Anxiety and phobia disorders: clinical guidelines]. Moscow, 2021. 103 p.
- Pushkarev G.S., Kuznetsov V.A., Yaroslavskaya E.I. Reliability and validity of the multidimensional scale of perceived social support (MSPSS): Russian version. Profilaktika 2015, 2015, pp. 42b–43a (in Russ.).
- Gartfel’der D.V. Socio-psychological and personal factors in the pathogenesis of cardiovascular diseases. Meditsinskaya psikhologiya v Rossii, 2010, no. 1, p. 9 (in Russ.).
- Anderson L., Oldridge N., Thompson D.R. et al. Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane systematic review and meta-analysis. Journal of the American college of cardiology, 2016, vol. 67 (1), pp. 1–12.
- Velikanov A.A., Stolyarova A.A., Kruglova N.E. The role of psychological rehabilitation in complex cardiac rehabilitation of patients with coronary heart disease. Natsional’nyy psikhologicheskiy zhurnal, 2020, vol. 4, no. 40, pp. 85–97 (in Russ.).
- Wilhelm M., Abreu A., Adami P.E. et al. EAPC core curriculum for preventive cardiology. European journal of preventive cardiology, 2022, vol. 29 (1), pp. 251–274.
- De Araújo Pio C.S., Marzolini S., Pakosh M. et al. Effect of cardiac rehabilitation dose on mortality and morbidity: a systematic review and meta-regression analysis. Mayo clinic proceedings. Elsevier, 2017. Vol. 92 (11). Pp. 1644–1659.
- Solodukhin A.V., Seryy A.V., Yanitskiy M.S. et al. Possibilities of cognitive-behavioral psychotherapy methods in changing the internal picture of the disease in patients with coronary heart disease. Fundamental’naya i klinicheskaya meditsina, 2017, vol. 2, no. 1, pp. 84–90 (in Russ.).
- Alekhin A.N. Psychological factors of cardiometabolic risk: history and current state of the problem. Arterial’naya gipertenziya, 2012, vol. 18, no. 4, pp. 278–291 (in Russ.).
- Nikolaev E.L., Lazareva E.Yu. Psychotherapy and psychological assistance to patients with cardiovascular diseases. Vestnik psikhiatrii i psikhologii Chuvashii, 2015, vol. 11, no. 1, pp. 57–76 (in Russ.).
- Carney R.M., Freedland K.E., Steinmeyer B. Depression and five-year survival following acute myocardial infarction: a prospective study. Journal of affective disorders, 2008, vol. 109 (1–2), pp. 133–138.
- Chair S.Y., Chan S.W., Thompson D.R. et al. Long-term effect of motivational interviewing on clinical and psychological outcomes and health-related quality of life in cardiac rehabilitation patients with poor motivation in Hong Kong: a randomized controlled trial. Clinical Rehabilitation, 2013, vol. 27 (12), pp. 1107–1117.
- Halaris A. Inflammation-associated co-morbidity between depression and cardiovascular disease. Curr Top Behav Neurosci, 2017, vol. 31, pp. 45–70.
- Franklin B.A., Rusia A., Haskin-Popp C. et al. Chronic stress, exercise and cardiovascular disease: placing the benefits and risks of physical activity into perspective. International journal of environmental research and public health, 2021, vol. 18 (18), pp. 9922.
- McCaffery J.M., Duan Q.L., Frasure-Smith N. et al. Genetic predictors of depressive symptoms in cardiac patients. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009, vol. 150 (3), pp. 381–388.
- Ghosh R.K., Ball S., Prasad V. et al. Depression in heart failure: Intricate relationship, pathophysiology and most updated evidence of interventions from recent clinical studies. International journal of cardiology, 2016, vol. 224, pp. 170–177.
- Fomicheva A.V., Andreev D.A., Volel’ B.A. Mental disorders in chronic heart failure. Psikhiatriya, 2021, vol. 19, no. 4, pp. 109–124 (in Russ.).
- Dovzhenko T.V., Semiglazova M.V., Krasnov V.N. et al. Anxiety and depressive disorders in cardiovascular diseases. Doktor.ru, 2010, no. 4, pp. 39–47 (in Russ.).
- Nakada S., Ho F.K., Celis-Morales C. et al. Individual and joint associations of anxiety disorder and depression with cardiovascular disease: A UK Biobank prospective cohort study. European Psychiatry, 2023, vol. 66 (1), p. e54.
- Fava G.A., Sonino N., Wise T.N. The Psychosomatic Assessment. Strategies to Improve Clinical Practice. Basel: Karger, 2012. Pp. 182–202.
- Rossiyskoe obshchestvo psikhiatrov. Generalizovannoe trevozhnoe rasstroystvo: klinicheskie rekomendatsii [Russian Society of Psychiatrists. Generalized anxiety disorder: clinical guidelines]. Moscow, 2021. 84 p.
- Bespalov Yu.I., Bespalova L.Yu., Adil’khanova K.A. et al. Clinical features of panic disorders against the background of somatic diseases. Vestnik Kazakhskogo natsional’nogo meditsinskogo universiteta, 2019, no. 1, pp. 194–196 (in Russ.).
- Shishkova V.N. Anxiety in patients with cardiovascular diseases: modern detection strategies and treatment options. Terapevticheskiy arkhiv, 2023, vol. 95, no. 8, pp. 710–715 (in Russ.).
- Nikolaev E.L., Lazareva E.Yu. Organizational aspects of psychological assistance to patients with cardiovascular diseases. Vestnik psikhoterapii, 2014, no. 49, p. 79 (in Russ.).
- Shkola zdorov’ya. Arterial’naya gipertoniya. Rukovodstvo dlya vrachey, pod red. R.G. Oganova [School of Health. Arterial hypertension. A guide for doctors, edited by Oganov R.G.]. Moscow: GEOTAR-Media, 2008. 192 p.
- Svetyy L.I., Lopukhova V.A., Tarasenko I.V. Assessing the effectiveness of a health school for elderly patients with chronic heart failure. Vestnik novykh meditsinskikh tekhnologiy, 2018, vol. 12, no. 3, pp. 91–96 (in Russ.).
- Ekkert N.V., Mikhaylovskiy V.V. Organization of “Health Schools” as the main factor in increasing the effectiveness of the prevention of cardiovascular diseases. Sechenovskiy vestnik, 2016, vol. 2, no. 24, pp. 58–62 (in Russ.).
- Gadaev A.G., Gulyamova Sh.S. Assessing the effectiveness of the school of hypertension at the level of primary health care. Profilakticheskaya meditsina, 2012, vol. 15, no. 3, pp. 7–15 (in Russ.).
- Miller W.R., Lasiter S., Ellis R.B. et al. Chronic disease self-management: a hybrid concept analysis. Nursing outlook, 2015, vol. 63 (2), pp. 154–161.
- Hevey D., O’Raghallaigh J.W., O’Doherty V. et al. Pre-post effectiveness evaluation of chronic disease self-management program (CDSMP) participation on health, well-being and health service utilization. Chronic illness, 2018, vol. 16 (2), pp. 146–158.
- Brady T.J., Murphy L., O’Colmain B.J. et al. Peer reviewed: A meta-analysis of health status, health behaviors, and health care utilization outcomes of the chronic disease self-management program. Preventing chronic disease, 2013, vol. 10, pp. 1201–1212.
- Miri J., Naderipour A., Ashtarian H. et al. The effect of chronic disease self-management program on health status of patients undergoing coronary artery bypass graft surgery. Journal of Critical Care Nursing, 2016, vol. 9 (1), pp. e5103.
- Seferovic P.M., Ponikowski P., Anker S.D. et al. Clinical practice update on heart failure 2019: pharmacotherapy, procedures, devices and patient management. An expert consensus meeting report of the Heart failure association of the European society of cardiology. European journal of heart failure, 2019, vol. 21 (10), pp. 1169–1186.
- Wahowiak L. Providing lifelong education and support: updates in the 2017 National standards for diabetes self-management education and support. Clinical Diabetes, 2017, vol. 35 (4), pp. 239–241.
- Vasserman L.I. Psikhologicheskaya diagnostika i korrektsiya v somaticheskoy klinike: nauchno-prakticheskoe rukovodstvo [Psychological diagnosis and correction in a somatic clinic: a scientific and practical guide]. Saint Petersburg: Rech, 2011. 270 p.
- Kuvshinova N.Yu. Psikhokorrektsionnaya rabota s bol’nymi ishemicheskoy bolezn’yu serdtsa s uchetom parametrov kachestva zhizni: avtoref. dis. … kand. psikh. nauk [Psychocorrectional work with patients with coronary heart disease, taking into account the parameters of quality of life. Synopsis of dis. PhD psychol. sciences]. Saint Petersburg, 2011. 29 p.
- Pogosova G.V. Anxiety states in patients with cardiovascular diseases: diagnostic and therapeutic aspects. Kardiovaskulyarnaya terapiya i profilaktika, 2006, vol. 5, no. 5, pp. 75–80 (in Russ.).
- Nagele E., Jeitler K., Horvath K. et al. Clinical effectiveness of stress-reduction techniques in patients with hypertension: systematic review and meta-analysis. Journal of hypertension, 2014, vol. 32 (10), pp. 1936–1944.
- Boytsov S.A., Pogosova N.V., Bubnova M.G. et al. Cardiovascular prevention 2017. Russian national recommendations. Rossiyskiy kardiologicheskiy zhurnal, 2018, no. 6, pp. 7–122 (in Russ.).
- Thompson D.R., Chair S.Y., Chan S.W. et al. Motivational interviewing: a useful approach to improving cardiovascular health? Journal of clinical nursing, 2011, vol. 20 (9–10), pp. 1236–1244.
- Kulikova M.S., Gornyy B.E., Kontsevaya A.V. et al. Effectiveness of remote technologies in monitoring and self-control of overweight and obesity in primary care patients. Profilakticheskaya meditsina, 2021, vol. 24, no. 10, pp. 24–31 (in Russ.).
- Berhe K.K., Gebru H.B., Kahsay H.B. Effect of motivational interviewing intervention on HgbA1C and depression in people with type 2 diabetes mellitus (systematic review and meta-analysis). PloS one, 2020, vol. 15 (10), p. e0240839.
- Poudel N., Kavookjian J., Scalese M.J. Motivational interviewing as a strategy to impact outcomes in heart failure patients: a systematic review. The Patient-Patient-Centered Outcomes Research, 2020, vol. 13 (1), pp. 43–55.
- Kühlmann A.Y., Etnel J.R., Roos-Hesselink J.W et al. Systematic review and meta-analysis of music interventions in hypertension treatment: a quest for answers. BMC cardiovascular disorders, 2016, vol. 16 (69), pp. 1–9.
- Siritunga S., Wijewardena K., Ekanayaka R. et al. Effect of music on state of ischaemiainstable angina; a randomized controlled trial. International Journal of Clinical Medicine, 2014, vol. 5 (19), pp. 1173–1179.
- Koelsch S., Boehlig A., Hohenadel M. et al. The impact of acute stress on hormones and cytokines and how their recovery is affected by music-evoked positive mood. Scientific reports, 2016, vol. 6 (1), p. 23008.
- Zakhar’yan E.A., Ibragimova R.E. Coping strategies and attitude to health in cardiac patients. Kompleksnye problemy serdechno-sosudistykh zabolevaniy, 2022, vol. 11, no. 4, pp. 7–12 (in Russ.).
- Chovdyrova G.S., Pyatkina O.A. Personal coping strategies when adapting to stress. Psikhopedagogika v pravookhranitel’nykh organakh, 2021, vol. 26, no. 1 (84), pp. 41–47 (in Russ.).
- Levashkevich Yu.L., Velikanov A.A., Yurlova T.G. et al. Cognitive errors as a target of psychocorrection in patients with coronary heart disease before and after coronary artery bypass surgery. Profilakticheskaya i klinicheskaya meditsina, 2015, no. 1 (54), pp. 110–114 (in Russ.).
- Velikanov A.A., Levashkevich Yu.L., Stolyarova A.A. et al. Cognitive errors and psychological characteristics of patients with coronary heart disease before coronary artery bypass surgery depending on gender and age. Sibirskiy psikhologicheskiy zhurnal, 2022, no. 83, pp. 184–203 (in Russ.).
- Reavell J., Hopkinson M., Clarkesmith D. et al. Effectiveness of cognitive behavioral therapy for depression and anxiety in patients with cardiovascular disease: a systematic review and meta-analysis. Psychosomatic medicine, 2018, vol. 80 (8), pp. 742–753.
- Lv J., Zhang X., Ou S. et al. Influence of cognitive behavioral therapy on mood and quality of life after stent implantation in young and middle-aged patients with coronary heart disease. International heart journal, 2016, vol. 57 (2), pp. 167–172.
- Blumenthal J.A., Sherwood A., Smith P.J. et al. Enhancing cardiac rehabilitation with stress management training: a randomized, clinical efficacy trial. Circulation, 2016, vol. 133 (14), pp. 1341–1350.
- Goodwin L., Ostuzzi G., Khan N. et al. Can we identify the active ingredients of behaviour change interventions for coronary heart disease patients? A systematic review and meta-analysis. PloS one, 2016, vol. 11 (4), p. e0153271.
- Barth J., Jacob T., Daha I. et al. Psychosocial interventions for smoking cessation in patients with coronary heart disease. Cochrane Database of Systematic Reviews, 2015, vol. 7.
- Fréchette-Simard C., Plante I., Bluteau J. Strategies included in cognitive behavioral therapy programs to treat internalized disorders: a systematic review. Cognitive Behaviour Therapy, 2018, vol. 47 (4), pp. 263–285.
- Wurst R., Kinkel S., Lin J. et al. Promoting physical activity through a psychological group intervention in cardiac rehabilitation: a randomized controlled trial. Journal of Behavioral Medicine, 2019, vol. 42 (6), pp. 1104–1116.
- Venuleo C., Mangeli G., Mossi P. et al. The cardiac rehabilitation psychodynamic group intervention (CR-PGI): an explorative study. Frontiers in psychology, 2018, vol. 9, p. 976.
- Košir M., Simonic B., Gostecnik C. et al. Relational Family Therapy in the Treatment of Sudden Cardiac Arrest Survivors and their Relatives. Pers. Chall. J. Theol. Educ. Canon Law. Soc. Stud. Inspired Pope John Paul II, 2021, vol. 11, p. 249.
- Medvedev V.E., Korovyakova E.A., Frolova V.I. et al. Antidepressive therapy in patients with cardiovascular diseases. Nevrologiya, neyropsikhiatriya, psikhosomatika, 2019, vol. 11, no. 1, pp. 131–140 (in Russ.).
- Andrade C., Sandarsh S., Chethan K.B. et al. Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms. J. Clin. Psychiatry, 2010, vol. 71 (12), pp. 1565–1575.
- Putilina M.V. Algorithm for prescribing antidepressants in real clinical practice. ConsiliumMedicum, 2018, vol. 20, no. 9, pp. 101–107 (in Russ.).
- Prikaz Ministerstva zdravookhraneniya i sotsial’nogo razvitiya RF ot 20.12.2012 no. 1219n “Ob utverzhdenii standarta pervichnoy mediko-sanitarnoy pomoshchi pri depressiyakh legkoy i sredney stepeni tyazhesti i smeshannom trevozhnom i depressivnom rasstroystve v ambulatornykh usloviyakh psikhonevrologicheskogo dispansera”. S izm. i dop. ot 05.07.2022 [Order of the Ministry of Health and Social Development of the Russian Federation dated December 20, 2012 No. 1219n “On approval of the standard of primary health care for mild and moderate depression and mixed anxiety and depressive disorder in an outpatient setting of a neuropsychiatric dispensary.” From change and additional from 07/05/2022].
- Zhidyaevskiy A.G., Mendelevich V.D., Galyautdinov G.S. et al. Features of mental disorders and their correction in patients with cardiac pathology. Kazanskiy meditsinskiy zhurnal, 2020, vol. 101, no. 2, pp. 212–225 (in Russ.).
- Endo N., Goto A., Suzuki T. et al. Factors associated with enrollment and adherence in outpatient cardiac rehabilitation in Japan. Journal of Cardiopulmonary Rehabilitation and Prevention, 2015, vol. 35 (3), pp. 186–192.
- Karavaeva T.A., Vasil’eva A.V., Poltorak S.V. et al. Principles and algorithms for psychopharmacological treatment of anxiety disorders of the neurotic level (anxious-phobic, panic and generalized anxiety disorders). Obozrenie psikhiatrii i meditsinskoy psikhologii im. V.M. Bekhtereva, 2016, no. 1, pp. 3–9 (in Russ.).
- MacQueen G.M., Frey B.N., Ismail Z. et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder. Canad. J. Psychiatry, 2016, vol. 61 (9), pp. 588–603.
- Andrade C., Sharma E. Serotonin reuptake inhibitors and risk of abnormal bleeding. Psychiatric Clinics, 2016, vol. 39 (3), pp. 413–426.
- Pagalilauan G.L., Thronson L.R. Psychopharmacology. Medical Clinics of North America, 2014, vol. 98 (5), pp. 927–958.
- Andrade C. Selective serotonin reuptake inhibitor drug interactions in patients receiving statins. The Journal of clinical psychiatry, 2014, vol. 75 (2), pp. e95–e99.
- Medvedev V.E., Chobanu I.K., Frolova V.I. et al. The effectiveness of psychopharmacotherapy and psychotherapy in patients with cardiovascular diseases. Arkhiv» vnutrenney meditsiny, 2013, no. 5, pp. 61–66 (in Russ.).
- Diminic-Lisica I., Popovic B., Rebic J. et al. Outcome of treatment with antidepressants in patients with hypertension and undetected depression. The International Journal of Psychiatry in Medicine, 2014, vol. 47 (2), pp. 115–129.
- Morimoto S.S., Kanellopoulos D., Manning K.J. et al. Diagnosis and treatment of depression and cognitive impairment in late life. Annals of the New York Academy of Sciences, 2015, vol. 1345 (1), pp. 36–46.
- Ivanov S.V., Volel’ B.A., Syrkina E.A. et al. Retrospective archival study to assess the safety of the use of modern antidepressants in cardiological practice. Terapevticheskiy arkhiv, 2017, vol. 89, no. 12, pp. 34–42 (in Russ.).
- Sivolap Yu.P. Systematics and treatment of anxiety disorders. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2020, vol. 120, no. 7, pp. 121–127 (in Russ.).
- Medvedev V.E. Prospects for the use of herbal anxiolytics in the treatment of anxiety disorders in patients with cardiovascular diseases. ConsiliumMedicum, 2010, vol. 12, no. 2, pp. 72–76 (in Russ.).
- Markota M., Rummans T.A., Bostwick J.M. et al. Benzodiazepine use in older adults: dangers, management, and alternative therapies. Mayo Clinic Proceedings. Elsevier, 2016. Vol. 91 (11). Pp. 1632–1639.
- Janeway D. An integrated approach to the diagnosis and treatment of anxiety within the practice of cardiology. Cardiology in review, 2009, vol. 17 (1), pp. 36–43.
- Stapel B., Sieve I., Falk C.S. et al. Second generation atypical antipsychotics olanzapine and aripiprazole reduce expression and secretion of inflammatory cytokines in human immune cells. Journal of psychiatric research, 2018, vol. 105, pp. 95–102.
- Howell S., Yarovova E., Khwanda A. et al. Cardiovascular effects of psychotic illnesses and antipsychotic therapy. Heart, 2019, vol. 105 (24), pp. 1852–1859.
- Wijesinghe R. A review of pharmacokinetic and pharmacodynamic interactions with antipsychotics. Mental Health Clinician, 2016, vol. 6 (1), pp. 21–27.
- Global Health Service Monitor 2023, available at: https://www.ipsos.ru/ru-ru/globalnyy-monitoring-zdravookhraneniya-2023 (accessed on: 08.01.2024).