E.A. GILIFANOV¹, V.A. NEVZOROVA¹, S.A. ARTYUSHKIN², V.B. TURKUTYUKOV¹, T.V. TILIK¹, N.V. VAISERO³, L.B. ARDEEVA¹ , I.V. KULIKOV

¹Pacific State Medical University, 2 Ostryakova Avenue, Vladivostok, Russian Federation, 690002

²North-Western State Medical University named after I.I. Mechnikov, 41 Kirochnaya St., St. Petersburg, Russian Federation, 191015

³Vladivostok Clinical Hospital № 1, 22 Sadovaya St., Vladivostok, Russian Federation, 690075 

Gilifanov E.A. — Cand. Med. Sc., Associate Professor of the Department of Ophthalmology and Otorhinolaryngology, tel.: (4232) 28-37-27, +7-914-705-76-10, e-mail: gilifanov@mail.ru

Nevzorova V.A. — D. Med. Sc., Professor of the Department of Therapy, Functional and Ultrasonic Diagnostics, tel. (4232) 45-17-02, e-mail: VGMU.nauka@mail.ru

Artyushkin S.A. — D. Med. Sc., Head of the Department of Otorhinolaryngology, tel. (812) 303-50-00, e-mail: Sergei.Artyushkin@spbmapo.ru

Turkutyukov V.B. — D. Med. Sc., Head of the Department of Epidemiology, tel. (4232) 45-17-02, e-mail: VGMU.nauka@mail.ru

Tilik T.V. — Cand. Med. Sc., Associate Professor of the Department of Ophthalmology and Otorhinolaryngology, tel. +7-902-48-46-321

Vaisero N.S. — Head of the Department of Microbiological Diagnostics, tel. (423) 245-38-36

Ardeeva L.B. — Assistаnt Lecturer of the Department of Ophthalmology and Otorhinolaryngology, tel.: (4232) 28-37-27, +7-914-791-67-70, e-mail: uka@land.ru

Kulikov I.V. — otolaryngologist of Surgical Department, Hospital of the Office of Federal Security Service of the Russian Federation

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality of adults worldwide. The aim of research was to study the microbiota of mucosa of upper respiratory tract (URT) in patients with COPD. St pyogenes was found significantly more frequent in patients with stable COPD and in patients with COPD exacerbation, and yeast-like С. аlbicans — in patients with COPD exacerbation. In patients with COPD, pathological processes were registered more frequently in pharynx and larynx. Bacterial flora of URT can dynamically and constantly change, thus there is a need for constant monitoring of epidemiologically significant microorganisms.

Key words: chronic obstructive pulmonary disease, bacterial flora, mucosa of upper respiratory tract.

REFERENCES

1. Avdeev S.N. Modern approaches to antibiotic treatment of exacerbations of chronic obstructive pulmonary disease. Pul’monologiya, 2012, no. 3, pp. 109-114 (in Russ.).
2. Hurst J.R. Upper airway. 3: Sinonasal involvement in chronic obstructive pulmonary disease. Thorax, 2010, vol. 65, no. 1, rr. 85-90.
3. Ryabova M.A., Nemykh O.V. Khronicheskiy laringit [Chronic laryngitis]. Saint Petersburg: Dialog, 2010. 140 p.
4. Gilifanov E.A., Nevzorova V.A., Artyushkin S.A. Funktsional’nyy status verkhnikh dykhatel’nykh putey i ukha u lits s khronicheskoy obstruktivnoy bolezn’yu legkikh [The functional status of the upper respiratory tract and ear infections in people with chronic obstructive pulmonary disease]. Nauka i praktika v otorinolaringologii: materialy chetvertoy regional’noy nauchno-prakticheskoy konferentsii (Khabarovsk, 09-10 oktyabrya 2013 g.). Khabarovsk, 2013. Pp. 3-9.
5. Lange P. Chronic obstructive pulmonary disease. Ugeskr. Laeger., 2013, vol. 175, no. 16, rr. 1105-1108.
6. Dzhenzhera G.E. Eligible we consider exacerbation of chronic obstructive pulmonary disease (COPD) and chronic rhinosinusitis single disease? Rossiyskaya rinologiya, 2009, no. 2, pp. 13-14 (in Russ.).
7. Piotrowska V.M. et al. Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids. Int. J. Chron. Obstruct. Pulmon. Dis., 2010, vol. 3, no. 5, rr. 7-17.
8. Izvin A.I., Kataev L.V. Microbial Landscape of the mucous membrane of the upper respiratory tract in health and disease. Vestnik otorinolaringologii, 2009, no. 2, pp. 64-68 (in Russ.).
9. Pal’chun V.T. et al. Zabolevaniya verkhnikh dykhatel’nykh putey i ukha [Diseases of the upper respiratory tract and ear]. Moscow: GOETAR-Media, 2013. 256 p.
10. Gilifanov E.A., Nevzorova V.A., Artyushkin S.A., Pavlush D.G. Clinical and functional characterization of hearing and speech in patients with stable chronic obstructive pulmonary disease. Tikhookeanskiy meditsinskiy zhurnal, 2014, no. 1, pp. 28-30 (in Russ.).
11. Kryukov A.I., Kunel’skaya V.Ya., Shadrin G.B. Aspects of modern epidemiology ENT mycosis. Vestnik otorinolaringologii, 2011, no. 2, pp. 13-15 (in Russ.).
12. Osipenko E.V. Anti-inflammatory therapy in the treatment of patients with chronic laryngitis. Vestnik otorinolaringologii, 2009, no. 4, pp. 63-65 (in Russ.).
13. Blotskiy A.A. Karpishchenko S.A., Katinas E.B. Gribkovye zabolevaniya LOR-organov [Fungal diseases of upper respiratory tract]. Saint Petersburg, Blagoveshchensk: Dialog, 2010. 140 p.
14. Kunel’skaya V.Ya. Mikozy v otorinolaringologii [Mycosis in otorhinolaryngology]. Moscow: Meditsina, 1989. 320 p.
15. Sobieraj D.M., White C.M., Coleman C.I. Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis. Clin. Ther., 2008, vol. 30, no. 8, rr. 1416-1425.