L.M. MIROLYUBOV, A.R. NURMEEVA, I.N. NURMEEV,
D.V. OSIPOV, D.R. SABIROVA
Kazan State Medical University
Children Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kaza
Kazan State Medical Academy

Nurmeeva Alsu Rashitovna
graduate student at the Department of Pediatric Surgery
140 Orenburgskiy Trakt Str., Kazan 420138
tel. 8-937-776-86-00, e-mail: alsu.nurmeeva@mail.ru

The article tells about the experience of diagnosis and treatment of 43 patients with a diagnosis of hemangioma treated with the drug propranolol in 2012-2013. The efficiency and safety of treatment of hemangiomas in children using propranolol therapy is estimated. Improvement was achieved in all patients. Propranolol therapy has shown to be an effective non-surgical method of treatment of hemangiomas . Hemodynamic changes and the potential risk of abnormal bradycardia require careful monitoring of patients by cardiologist with control of ECG and echocardioscopy during the whole period of treatment with propranolol.

Key words: children, hemangioma, treatment, propranolol.

REFERENCES

1. Tan O.T., Gilchrest B.A. Laser therapy for selected cutaneous vascular lesions in the pediatric population: a review // Pediatrics. — 1988. — Vol. 82. — P. 652-62.

2. Starkey E., Shahidullah H. Propranolol for infantile haemangiomas: a review // Arch Dis Child. — 2011 Sep. — Vol. 96, № 9. — P. 890-3.

3. Dalby T.K., Lester-Smith D. Propranolol for the treatment of infantile haemangioma// J Paediatr Child Health. — 2013 Feb. — Vol. 49, № 2. — P. 148-51.

4. Fette A. Popranolol in use for treatment of complex infant hemangiomas: literature review regarding current guidelines for preassessment and standards of care before initiation of therapy // Scientific World Journal. — 2013 May 20. — 850193, doi: 10.1155/2013/850193.

5. Bajaj Y., Kapoor K., Ifeacho S., Jephson C.G., Albert D.M., Harper J.I., Hartley B.E. Great Ormond Street Hospital treatment guidelines for use of propranolol in infantile isolated subglottichaemangioma // J Laryngol Otol. — 2013 Feb 1. — P. 1-4.

6. Fay A., Nguyen J., Waner M. Conceptual approach to the management of infantile hemangiomas // J Pediatr. — 2010 Dec. — Vol. 157, № 6. — P. 881-8.

7. Kallen R.J., Mohler J.H., Lin H.L. Hypoglycemia: a complication of treatment of hypertension with propranolol // ClinPediatr (Phila). — 1980 Aug. — Vol. 19, № 8. — P. 567-8.

8. Lane A.S., Woodward A.C., Goldman M.R. Massive propranolol overdose poorly responsive to pharmacologic therapy: use of the intra-aortic balloon pump // Ann Emerg Med. — 1987 Dec. — Vol. 16, № 12. — P. 1381-3.

9. Pavlakovic H., Kietz S., Lauerer P., Zutt M., Lakomek M. Hyperkalemia complicating propranolol treatment of an infantile hemangioma // Pediatrics. — 2010 Dec. — Vol. 126, № 6. — P(e)1589-93.

10. El-Shabrawi M., Hassanin F. Propranolol safety profile in children // Curr Drug Saf. — 2011 Sep, 1. — Vol. 6, № 4. — P.  259-66.

11. Ostman-Smith I. Hypertrophic cardiomyopathy in childhood and adolescence — strategies to prevent sudden death // FundamClinPharmacol. — 2010 Oct. — Vol. 24, № 5. — P. 637-52.

12. Seggewiss H., Rigopoulos A. Management of hypertrophic cardiomyopathy in children // Paediatr Drugs. — 2003. — Vol. 5, № 10. — P. 663-72.

13. Samanta T., Purkait R., Sarkar M., Misra A., Ganguly S. Effectiveness of beta blockers in primary prophylaxis of variceal bleeding in children with portal hypertension // Trop Gastroenterol. — 2011 Oct-Dec. — Vol. 32, № 4. — P. 299-303.

14. Graham E.M., Bandisode V.M., Bradley S.M., Crawford F.A. Jr., Simsic J.M., Atz A.M. Effect of preoperative use of propranolol on postoperative outcome in patients with tetralogy of Fallot // Am J Cardiol. — 2008 Mar 1. — Vol. 101, № 5. — P. 693-5.

15. Hesse B., Pedersen J.T. Hypoglycaemia after propranolol in children // Acta Med Scand. — 1973 Jun. — Vol. 193, № 6. — P. 551-2.

16. Eibs H.G., Oberdisse U., Brambach U. Intoxication by beta-blockers in children and adolescents (author’s transl) // Monatsschr Kinderheilkd. — 1982 May. — Vol. 130, № 5. — P. 292-5.