T.E. KURMANBAEV¹, I.YU. KOGAN², I.G. MUSTAFIN³, A.A. EROKHINA⁴, N.A. MAKSIMOVA⁵, E.V. FREDERIKS¹, A.O. ZHOGLO¹

¹Maternity Hospital № 13, St. Petersburg

²Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, St. Petersburg

³Kazan State Medical University, Kazan

⁴Military Clinical Hospital № 442, St. Petersburg

⁵N.N. Petrov National Medical Research Oncology Center, St. Petersburg

Contact details:

Kurmanbaev T.E. — PhD (Medicine), obstetrician-gynecologist of the Maternity Ward

Address: 4 Kostromskaya St., 191124 St. Petersburg, Russian Federation, tel.: +7 (812) 271-01-90, e-mail: timka_rus@inbox.ru

An important link in preeclampsia pathogenesis is a violation of placental perfusion. In preeclampsia, the number of microvesicles containing placental alkaline phosphatase, an enzyme with an unknown function, increases in the mother’s systemic bloodstream.

The purpose — to determine the relationship between the placental alkaline phosphatase expression and the severity of dystrophic changes in placental tissue in preeclampsia of varying severity.

Material and methods. The study included 15 patients with severe preeclampsia (group 1), 15 patients with moderate preeclampsia (group 2), and 16 patients without hypertensive syndrome (group 3) at 29–40 weeks of gestation. In placental tissue samples, the placental alkaline phosphatase expression was assessed, as well as the severity of dystrophic changes — vascular thrombosis and villous fibrosis.

Results. In severe preeclampsia, the most pronounced dystrophic changes were found, as well as high expression of placental alkaline phosphatase. A relationship was established between the expression of placental alkaline phosphatase and the degree of dystrophic changes in the placental tissue (p < 0.05).

Conclusion. A high expression of placental alkaline phosphatase is observed in the cytoplasm of cytotrophoblast cells in severe preeclampsia, which is interconnected with the severity of dystrophic changes, and in our opinion, can be regarded as a sign of placental dysfunction.

Key words: preeclampsia, placental alkaline phosphatase, placental dysfunction.

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