O.Yu. KARPUKHIN^1,2, A.F. SHAKUROV¹, M.O. KOPORULINA³

¹Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

²Republican Clinical Hospital, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420068

³Kazan State Medical Academy, 36 Butlerova St., Kazan, Russian Federation 420012

Karpukhin O.Yu. — D. Med. Sc., Professor of the Department of Surgical Diseases № 1, tel. +7-905-312-92-90, e-mail: olegkarpukhin@rambler.ru^1,2

Shakurov A.F. — postgraduate student of the Department of Surgical Diseases № 1, tel. +7-904-660-11-39, e-mail: aydarsha@gmail.com¹

Koporulina M.O. — junior researcher of the Central Research Laboratory, tel. (843) 236-30-82, e-mail: koporulina.mo@gmail.com³

Severe constipation lead to changes in the intestinal microflora along with an excessive development of conditionally-pathogenic microorganisms, increase of the amount of endotoxin (lipopolysaccharide of the bacterial wall) entering into systemic blood flow with further potential development of various pathological processes and diseases. There was made a study of endotoxinemia in patients with chronic constipation before and after treatment. The study showed that in patients with chronic constipation there is a significant increase in concentration of endotoxin in the blood as compared with the comparison group: 3,72±1,4 EU/ml versus 0,41±of 0.2 (p<0.01), and its maximum value, 5,58±2.1 (p<0.01) was observed in the decompensated form of chronic colostasis. In postoperative period, patients from this group had simultaneous reduction of Wexner index (3.9±0,6 (p<0.01) ) and endotoxemia (0.35±0,14 EU/ml (p<0.01)). Based on this study, measuring of levels of endotoxemia could be recommended as one of the criteria of objectification of the severity of chronic constipation as well as efficiency of its treatment.

Key words: chronic constipation, endotoxin, efficiency of treatment.

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