M.R. SHAIDULLINA^1, 2, E.O. POTAPOVA², G.R. HAZIAHMETOVA¹, D.R. SINGATULLINA²

 ¹Republican Сhildren’s Clinical Hospital, Kazan

²Kazan State Medical University, Kazan

³Kazan Endocrinology Dispensary, Kazan

Contact details:

Shaidullina M.R. — PhD (Medicine), Associate Professor of the Department of Endocrinology, Head of the Endocrinology Department

Address: 140 Orenburgsky trakt, 420064 Kazan, Russian Federation, tel.: +7-960-045-67-79, e-mail: zizi97@mail.ru

The article presents the results of an analysis of blood cortisol levels at the end of the first month of life in preterm infants and its association with certain health parameters in the neonatal period and at the age of 5 years. We studied 150 inpatients medical records from the Department of Neonatal Pathology and 139 electronic outpatient records of the same patients at the age of 5. It was demonstrated the blood cortisol level in preterm infants at the end of the premature period was 128.45 (79.175; 222.725) nmol/l. Children born weighing less than 1000g and/or before 28 weeks of gestation have a higher blood cortisol concentration at the age of 1 month compared to other groups, but this difference is statistically insignificant.

The use of inhaled forms of budesonide in preterm newborns does not have a significant systemic effect; dexamethasone introduction as eye drops in these patients significantly reduced blood cortisol concentration. Cortisol levels at the end of the neonatal period in preterm infants are associated with the risk of ophthalmological pathology at the age of 5 years.

Key words: premature babies; children with low, very low and extremely low body weight; adrenal glands, cortisol, catamnesis.

REFERENCES

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