E.S. KOSARENKO^1, 2, T.V. ZUEVSKAYA¹, M.D. ORLOV³, S.I. EREMEEV¹, S.S. ROMANCHENKO²

¹Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk

²Khanty-Mansiysk Regional Clinical Hospital, Khanty-Mansiysk

³Tyumen State Medical University, Tyumen

 Contact details:

Kosarenko E.S. — Senior Lecturer of the Department of Hospital Therapy, gastroenterologist

Address: 40 Mira St., Khanty-Mansiysk, Russian Federation, 628011, tel.: +7 (3467) 39-03-19, e-mail: kosarenko_es@mail.ru

The purpose — to determine the laboratory features of autoimmune liver diseases occurring against the background of opisthorchiasis invasion, to assess the effect of opisthorchiasis on the course of autoimmune liver diseases.

Material and methods The study is a prospective analysis of the survey results of patients with autoimmune liver diseases and combined autoimmune and parasitic liver damage. The methodological basis of the study was general scientific, general logical and special methods.

Results. A comparative analysis of laboratory parameters in autoimmune liver diseases with and without opisthorchiasis invasion was carried out. It was found that patients with comorbidity had statistically significantly higher levels of urea (p=0.001), glucose (p=0.014) and total cholesterol (p = 0.012).

Conclusion. It was determined that in autoimmune liver diseases associated with opisthorchiasis, there are no specific pathognomonic laboratory signs, which is important to consider when conducting differential diagnosis. Therefore, all patients suffering from opisthorchiasis, regardless of the previously established diagnosis, in the presence of hepatosplenomegaly, persistent cytolysis and/or cholestasis, require an additional examination for autoimmune liver damage, according to the current diagnostic algorithms, especially if they are combined with anemia and other cytopenias, autoimmune diseases, aggravated heredity for autoimmune pathology, or a sharp increase in γ-globulins (IgG).

Key words: autoimmune liver diseases, autoimmune hepatitis, primary biliary cholangitis, оverlapping syndromes, opisthorchiasis.

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