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  • Interrelation of morphofunctional parameters of the retina and cytokine profile of the removed epiretinal membranes  

    Редактор | 2017, Original articles, Practical medicine 03 (17) Ophthalmology | 27 апреля, 2017

    U.R. ALTYNBAEV1, A.I. LEBEDEVA2

    1Medical Centre of Open Joint-Stock Company «Tatneft», 67 Radishev Str., Almetyevsk, Russian Federation, 423450

    2All-Russia Center for Eye and Plastic Surgery of the Health Ministry of the Russian Federation, 67/1 Zorge Str., Ufa, Russian Federation, 450075

     Altynbaev U.R. ― Cand. Med. Sc., doctor of ophthalmology department, tel. (8553) 31-10-64, e-mail: uralaltynbaev@rambler.ru

    Lebedeva A.I. ― Cand. Biol. Sc., Head of Histology and Immunohistochemistry Laboratory of the Morphology Department, tel. +7-903-351-02-07, e-mail: morpholetter@yandex.ru

    A correlation analysis was made between the immunomorphological features of 17 removed idiopathic epiretinal membranes and the morphofunctional parameters of the retina in the pre- and postoperative period. It was found that at the initial changes of retina changes, the expression of glial fibrillar acid protein is predominantly determined in distant idiopathic epiretinal membranes, while as the neurodegenerative process progresses, the content of fibronectin and laminin increases.

    Key words: idiopathic epiretinal membrane, fibronectin, laminin, glial fibrillar acidic protein.

    REFERENCES

    1. Fraser-Bell S.1., Guzowski M. Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains Eye Study. Ophthalmology, 2003, Jan, 110 (1), rr. 34-40.
    2. Hikichi T., Takahashi M. Relationship between premacular cortical vitreous defects and idiopathic premacular fibrosis. Retina, 1995, vol. 15, 5, rr. 413-416.
    3. Kishi S., Demaria C. Vitreous cortex remnants at the fovea after spontaneous vitreous detachment. International Ophthalmology, 1986, vol. 9, 4, rr. 253-260.
    4. Mandal N., Kofod M. Proteomic analysis of human vitreous associated with idiopathic epiretinal membrane. Acta Ophthalmologica, 2013, vol. 91, 4, rr. 333-334.
    5. Altynbaev U.R., Lebedeva A.I. Morphological study of idiopathic epiretinal membranes and their cytokine profile. Oftal’mologicheskie vedomosti, 2016, vol. 9, no. 4, pp. 13-17 (in Russ.).
    6. Weller M.1., Wiedemann P. The significance of fibronectin in vitreoretinal pathology. A critical evaluation. Graefes Arch Clin. Exp. Ophthalmol, 1988, 226 (3), rr. 294-298.

    Метки: 2017, A.I. LEBEDEVA, fibronectin, glial fibrillar acidic protein, idiopathic epiretinal membrane, laminin, Practical medicine 03 (17) Ophthalmology, U.R. ALTYNBAEV

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