I.N. ZAKHAROVA¹, T.M. TVOROGOVA¹, E.A. SOLOVJEVA^1,2, N.G. SUGYAN^1,2, N.E. ANTONENKO³, N.D. BALASHOVA³, N.K. KUULAR³, V.V. MARCHENKO³, S.V. PEROVA³, V.N. PROSTAKOVA³, N.Yu. SIMAKOVA³, I.M. SIMONENKO³, S.V. VASILJEVA¹, M.V. MOZZHUKHINA¹, E.Yu. KOROLEVA⁴, A.V. RAKHTEENKO¹, L.Ya. KLIMOV⁵, V.A. KURYANINOVA⁵ , PLIDOVSKI PAVEL⁶.  

 ¹Russian Medical Academy of Continuing Postgraduate Education of the Ministry of Health of the Russian Federation, Moscow

²Children’s city polyclinic No.133 of the Department of Health care of Moscow, Moscow

³Children’s Medical Center of the Presidential Administration of the Russian Federation, Moscow

⁴Clinic of the group of companies “Mother and Child”, Moscow

⁵Stavropol State Medical University of the Ministry of Health of the Russian Federation

⁶The Children’s Memorial Health Institute, Warsaw, Poland

For correspondence:

Zakharova I.N. – D. Med. Sc., Professor, Honored Doctor the Russian Federation, Head of the Department of Pediatrics of the Russian Medical Academy of Continuous Post-graduate training, 2/1 Barrikadnaya Str., 125993, Moscow, tel. (499) 252-21-04, e-mail: zakharova-rmapo@yandex.ru

The article is devoted to the analysis of vitamin D provision for children belonging to different age groups and living in Moscow, and to the assess of the seasonality of fluctuations in vitamin D levels in this population. The results of the determination of the level 25 (OH) D in 1,041 children aged 1 month to 18 years collected during the period from 2012 to 2015 are analyzed. According to the analysis, regardless of age, a high percentage of vitamin D deficiency among children in the city of Moscow was detected. The generally accepted optimal level of a metabolite of vitamin D-calcidiol in the blood (> 30 ng / ml) was observed only in a small part of the subjects (26%), while the greater part (74%) showed an insufficient level of vitamin D of varying severity: 28%-  insufficiency (20-29 ng / ml), 33% — deficiency (<20 ng / ml), 13% — severe deficiency (<10 ng / ml). With age, the level of insufficiency is more pronounced.

 In the analysis of seasonality, there was a significant difference in vitamin D levels between the summer and winter seasons (p = 0.001). The greatest decrease in vitamin D availability was found in winter (median level 25 (OH) D 17.0 (11.0, 25.0) ng / ml). In the summer months, the relative increase in calcidiol was recorded (median 22.9 (18.0, 33.0) ng / ml), which, however, does not reach the level of normal availability. Children and, especially, adolescents living in Moscow, need year-round prophylaxis of hypovitaminosis D with medications of cholecalciferol.

Key words: vitamin D, cholecalciferol, hypovitaminosis D, vitamin D deficiency, provision of adolescents with vitamin D, provision of young children with vitamin D, seasonal changes in vitamin D status in children.

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