A.V. TERESHCHENKO, I.G. TRIFANENKOVA, E.V. EROKHINA

Kaluga branch of the S. Fyodorov Eye Microsurgery Federal State Institution, 5, Svyatoslav Fyodorov Str., Kaluga, Russian Federation, 248007

  Tereshchenko A.V. ― D. Med. Sc, Director, tel. (4842) 505-767, e-mail: nauka@mntk.kaluga.ru

Trifanenkova I.G. ― Cand. Med. Sc., Deputy Director for Research, tel. (4842) 505-767, e-mail: nauka@mntk.kaluga.ru

Erokhina E.V. ― Head of the Diagnostic Department №2, tel. (4842) 505-767, e-mail: nauka@mntk.kaluga.ru

 The research objective is to reveal the informative value of optical coherence tomography-angiography for the estimation of retinal vessels condition in children with active retinopathy of prematurity.

Material and methods. 14 patients (28 eyes) with different stages of active ROP at the age of 4-9 weeks (31-38 weeks of post-conceptual age) were studied. Stage 3 of classic ROP in zone I was revealed in 3 patients, in zone II ― in 1 patient, 4A stage in the zone II ― in 4 children. Aggressive posterior ROP were diagnosed in 7 children, in 3 ― at the stage of early clinical manifestations, in 4 ― at the stage of manifestation. In addition to the standard examination, the patients underwent digital retinoscope with digital morphometry, FA, SOCT and OCT-A.

Results. In children with 3 and 4A stages of active ROP in the zone II, OCT-A revealed no pathological changes in the capillary bed in the central zone of the retina. In patients with 3 stage of active ROP in the zone I, plots of epiretinal neovascularization was determined within the foveal region. At the stage of early clinical manifestations of aggressive posterior ROP, intraretinal neovascular complexes and multiple arterio-venous shunts were visualized in the superficial vascular plexus in all segments within the perifovea. At the stage of manifestation of aggressive posterior ROP, a gross disturbance of the architectonics in the superficial and deep vascular plexuses was determined, dilated and tortuous vessels of the upper temporal vascular arcade were revealed, along which multiple intra- and epiretinal neovascular complexes were spread.

Conclusion. OCT-A is a valuable method of diagnosis in infants with active stages of ROP. The identified pathological changes require further clinical research.

Key words: optical coherence tomography ― angiography, retinopathy of prematurity, aggressive posterior retinopathy of prematurity.

REFERENCES

1. Tereshchenko A.V., Belyy YU.A., Trifanenkova I.G. et al. Fluorescence angiography in diagnosis and determination of treatment tactics for active stages of retinopathy of prematurity. Vestnik Tambovskogo universiteta, 2014, vol. 19, iss. 4, pp. 1218-1220 (in Russ.).
2. Tereshchenko A.V., Belyy YU.A., Trifanenkova I.G. et al. The possibilities of fluorescent angiography in diagnosis and determination of the tactics of treatment of active stages of retinopathy of prematurity. Oftalʹmokhirurgiya, 2014, no. 4, pp. 74-78 (in Russ.).
3. Trifanenkova I.G., Tereshchenko A.V. The study of the possibilities of fluorescent angiography in assessing the regression of cicatricial stages of retinopathy of prematurity. Sovremennye tekhnologii v oftalʹmologii, 2017, vol. 18, no. 5, pp. 192-195 (in Russ.).
4. Tereshchenko A.V., Belyy YU.A., Trifanenkova I.G. et al. Optical coherence tomography in children with early stages of active retinopathy of prematurity. Oftalʹmokhirurgiya, 2005, no. 4, pp. 48-51 (in Russ.).
5. Tereshchenko A.V., Trifanenkova I.G., Erokhina E.V., Sidorova YU.A. Informativeness of the method of spectral optical coherence tomography with posterior aggressive retinopathy of prematurity. Oftalʹmologiya, 2017, vol. 15, no. 3, pp. 240-246 (in Russ.).
6. Tereshchenko A.V., Belyy YU.A., Erokhina E.V. Anatomico-topographic features of the anterior part of the eye in children with retinopathy of prematurity according to ultrasonic biomicroscopy data. Vestnik Tambovskogo universiteta, 2014, vol. 19, iss. 4, pp. 1204-1206 (in Russ.).
7. Erokhina E.V., Tereshchenko A.V., Tereshchenkova M.S., Panamareva S.V. Informativeness of ultrasonic biomicroscopy in diagnostics of active stages of retinopathy of prematurity. Vestnik OGU, 2014, vol. 173, no. 12, pp. 127-132 (in Russ.).
8. Tereshchenko A.V., Belyy YU.A., Erokhina E.V., Trifanenkova I.G. Use of ultrasonic biomicroscopy in premature infants. Oftalʹmokhirurgiya, 2015, no. 4, pp. 30-35 (in Russ.).
9. Tereshchenko A.V., Trifanenkova I.G., Panamareva S.V. Color dopplerography for retinopathy of prematurity. Regionarnoe krovoobrashchenie i mikrotsirkulyatsiya, 2017, no. 3, pp. 10-14 (in Russ.).
10. Campbell J., Nudleman E., Yang J. et al. Handheld Optical Coherence Tomography Angiography and Ultra-Wide-Field Optical Coherence Tomography in Retinopathy of Prematurity. JAMA Ophthalmol, 2017, vol. 135, no. 9, pp. 977-981.