М.М. GURОVA^{1, 2, 3, L}.I. FETISOVA², L.V. RUZHITSKAYA², L.M. PETROVA⁴, G.D. SEMENOVA⁴

¹ Laboratory “Medical and social problems in pediatrics” of the National Research Center “St. Petersburg State Pediatric University”, 2 Litovskaya St., St. Petersburg, Russian Federation 194100

² Belgorod State National Research University, 85 Pobedy St., Belgorod, Russian Federation 308015

³ Clinical and Diagnostic Center for Children 36 Oleko Dundicha St., building 2, St. Petersburg, Russian Federation 192289

⁴ Children’s Regional Clinical Hospital, 44 Gubkina St., Belgorod, Russian Federation 308036

 Contact details:

Gurova M.M. – D. Med. Sc., Leading Research Associate, Head of the Department of Abdominal Pathology, Professor of the Department of Pediatrics with the course of children surgical diseases of the Medical Institute, e-mail: itely@mail.ru

Fetisova V.I. — the 6th year student of the Faculty of Medical treatment of the Medical Institute, e-mail: valmel93@ya.ru

Ruzhitskaya L.V. – the 6th year student of the Faculty of Medical treatment of the Medical Institute, e-mail: lida ruz-7@mail.ru

Petrova L.M. — Head of the Pediatric Department No. 1, Honored Doctor of the Russian Federation, tel. (4722) 73-94-14, e-mail: dob@belodb.ru

Semenova G.D. — Doctor-Ordinator of the Pediatric Department No. 1, Children’s Endocrinologist, Honored Doctor of the Russian Federation, tel. (4722) 73-94-14, e-mail: dob@belodb.ru

Received: March 11, 2018, accepted for printing: April 9, 2018.

 To assess the state of the digestive system and metabolic processes in children with type 1 diabetes mellitus (DM), depending on the age of the disease, 70 patients were divided into 3 groups: the 1^st group — 22 children with DM duration up to 1 year, the 2^nd group — 23 children with duration of the disease from 1 to 5 years, the 3^rd group — 25 patients suffering from diabetes more than 5 years. The assessment of complaints, laboratory tests with additional assessment of lipid metabolism, esophagogastroduodenoscopy, ultrasound evaluation of the liver, pancreas and gallbladder was carried out. Complaints from the digestive system appear in children with diabetes early enough — during the first year from the onset of the disease, appearing after one year of illness in 100% of children. With increasing prescription of the disease, the number of children with dyspeptic complaints increases, the severity of pathological changes on the part of the gastrointestinal tract is often-observed — the number of children with catarrhal esophagitis, widespread gastritis, hepatomegaly and signs of diffuse changes in the liver and pancreas as measured by ultrasound grows. The revealed changes are accompanied by an increase in the severity of atherogenic dyslipidemia with a prescription of the disease for more than 5 years.

Key words: children, type 1 diabetes mellitus, gastrointestinal tract, duration of the disease, lipid metabolism, liver condition, pancreas condition.

 (For citation: Gurova M.M., Fetisova V.I., Ruzhitskaya L.V., Petrova L.I., Semenova G.D. Influence of the duration of type I diabetes mellitus in children on the metabolic characteristics and state of the digestive system. Practical medicine. 2018)

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