M.A. OVCHINNIKOV, I.S. LIPATOV, G.V. SANTALOVA, Yu.V. TEZIKOV, S.V. PLAKHOTNIKOVA

Samara State Medical University, 89 Chapaevskaya Str., Samara, Russian Federation, 443099

Ovchinnikova M.A. ― postgraduate student of the Department of Faculty Pediatrics, e-mail: marinasharypova@yandex.ru

The article presents a comprehensive assessment of the impact of pregnancy peculiarities in women with recurrent herpetic infection on the health of newborns. According to the results of the study, a beneficial effect was revealed of pre-gestational and antenatal prevention of herpetic infection recurrences by the newly developed method with the use of drugs Alloferon and the human recombinant α — 2в interferon on the course of pregnancy, condition of fetal-placental complex, and mechanisms of photoprotection in relation to intrauterine infection with herpes simplex virus. The developed method reduces the risk of intrauterine infection of the fetus 22.2 times compared with the group subjected to only occasional systemic chemotherapy, and 39.8 time compared to the group where prevention of herpetic infection recurrence was not conducted. Association was proved between the preventive therapy effectiveness, the frequency and severity of gestation complications and the somatic health of the newborn. The method of fetus intrauterine infection prevention with the use of antiviral and immunomodulatory drugs meets the modern requirements of perinatal pharmacology, it is available and economically affordable.

Key words: recurrent herpes infection, antenatal prevention, Allokin-alpha, Viferon, intrauterine infection, children’s health.

REFERENCES

1. Santalova G.V., Valeeva G.R., Lipatov I.S., Tezikov Yu.V. Analysis of somatic pathology of children born to herpes-infected mothers. Vestnik Rossiyskogo universiteta druzhby narodov. Seriya: Meditsina, 2009, no. 4, pp. 210-215 (in Russ.).
2. Tsinzerling V.A. Intrauterine infections: a modern view of the problem. Zhurnal infektologii, 2014, vol. 6, no. 4, pp. 5-10 (in Russ.).
3. Katkova L.I., Galakhova O.O., Shcherbitskaya O.V.  New methods for predicting intrauterine infections in newborns. Sovremennye problemy nauki i obrazovaniya, 2016, no. 5, pp. 27-34 (in Russ.).
4. Ovchinnikova M.A. Influence of the recurrent course of herpetic infection in pregnant women on the fetoplacental complex and the course of the early neonatal period in children. Aspirantskiy vestnik Povolzh’ya, 2014, no. 1 (2), pp. 123-7 (in Russ.).
5. Lobzin Yu.V., Skripchenko N.V., Vasil’ev V.V. Congenital infections: problems and solutions. Zdorov’e ― osnova chelovecheskogo potentsiala: problemy i puti ikh resheniya, 2016, vol. 11, no. 2, pp. 577-578 (in Russ.).
6. Mardanly S.G. Tasks and prospects for improving clinical laboratory diagnosis of TORCH infections. Vestnik sluzhby krovi Rossii, 2013, no. 2, pp. 54-60 (in Russ.).
7. Gardella C., Brown Z. Prevention of neonatal herpes. BJOG, 2011, vol. 118, no. 2, pp. 187-192. DOI: 10.1111/j.1471-0528.2010.02785.x.
8. Lipatov I.S., Tezikov Yu.V., Santalova G.V., Ovchinnikova M.A. Prevention of recurrence of herpetic infection in pregnant and intrauterine infection of the fetus with herpes simplex virus. Rossiyskiy vestnik akushera-ginekologa, 2014, vol. 14, no. 4, pp. 63-68 (in Russ.).
9. Duda A.K., Kotsyubaylo L.P., Okruzhnov N.V. Application of an antiviral drug of the new generation Allokin-alpha in the treatment of socially significant viral infections. Aktual’naya infektologiya, 2014, no. 4 (5), pp. 32-41 (in Russ.).
10. Sosnova E.A. Pregravidar preparation of patients with viral infections. Voprosy ginekologii, akusherstva i perinatologii, 2011, vol. 10, no. 5, pp. 72-78 (in Russ.).
11. Nesterova I.V., Kovaleva S.V., Kleshchenko E.I. et al. A modified program of combined interferon and immunotherapy with associated respiratory and herpetic viral infections in immunocompromised children. Effektivnaya farmakoterapiya, 2013, no. 27, pp. 26-32 (in Russ.).
12. Klinicheskie rekomendatsii (protokol lecheniya) okazaniya meditsinskoy pomoshchi vzroslym bol’nym prostym gerpesom. Utverzhdeno na zasedanii Profil’noy komissii Minzdrava RF po spetsial’nosti “infektsionnye bolezni” 04 noyabrya 2016 g. [Clinical recommendations (protocol of treatment) of rendering medical aid to adults with herpes simplex. Approved at the meeting of the Profile Commission of the Ministry of Health of the Russian Federation for the specialty «infectious diseases» on November 4, 2016].
13. Tezikov Yu.V., Lipatov I.S., Frolova N.A. et al. Informativeness of predictors of large obstetric syndromes in pregnant women with embryoplacental dysfunction. Aspirantskiy vestnik Povolzh’ya, 2015, no. 5 (6), pp. 48-55 (in Russ.).
14. Lipatov I.S., Tezikov Yu.V., Martynova N.V. et al. Universal approach to the prevention of the syndrome of pathological pregnancy. Nauka i innovatsii v meditsine, 2017, no. 1, pp. 13-23 (in Russ.).
15. Kotel’nikov G.P., Shpigel’ A.S. Dokazatel’naya meditsina. Nauchno-obosnovannaya meditsinskaya praktika: monografiya. izd. 2-e pererab i dop. [Evidence-based medicine. Scientific-based medical practice: a monograph. ed. 2-nd revision and add]. Moscow: GEOTAR-Media, 2012. 242 p.