A.N. YAKOVLEV¹, N.V. PASHKEVICH¹, V.I. VITCHINKINA¹, V.M. BRODYANSKIY², N.A. CHUPROVA², A.V. SHCHURINA², R.A. ROMASHKIN², A.A. TKACHEV¹, M.I. KOROSTIN¹

¹Lipetsk Regional Narcological Dispensary, 18 Leningradskaya Str., Lipetsk, Russian Federation, 398006

²V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, 3 Maliy Mogiltsevskiy pereulok, Moscow, Russian Federation, 119002

Yakovlev A.N. ― Cand. Med. Sc., psychiatrist-narcologist, tel. +7-910-352-71-31, e-mail: yakovlev_an75@mail.ru

Pashkevich N.V. ― psychiatrist-narcologist, tel. (4742) 73-05-50, e-mail: narkolog48@mail.ru

Vitchinkina V.I. ― Head of the Laboratory of Clinical Diagnostics, tel. (4742) 73-06-45, e-mail: narkolog48@mail.ru

Brodyansky V.M. — Cand. Biol. Sc., Leading researcher of the Molecular Genetics Laboratory, tel. (499) 241-04-65, e-mail: druggen@mail.ru

Chuprova N.A. — researcher of the Molecular Genetics Laboratory, tel. (499) 241-04-65, e-mail: druggen@mail.ru

Schurina A.V. — researcher of the Molecular Genetics Laboratory, tel. (499) 241-04-65, e-mail: druggen@mail.ru

Romashkin R.A. — researcher of the Molecular Genetics Laboratory, tel. (499) 241-04-65, e-mail: druggen@mail.ru

Tkachev A.A. ― clinical psychologist, tel. (4742) 73-05-50, e-mail: narkolog48@mail.ru

Korostin M.I. ― psychiatrist-narcologist, tel. (4742) 73-06-45, e-mail: narkolog48@mail.ru

We studied the genetic risk of chemical dependency formation on genoprofile of 5 loci of the dopamine-mediated system (4 loci of genes of dopamine receptors of types 2 and 4, tyrosine hydroxylase gene) and negative microsocial factors (questionnaire «Assessment of risk and opportunity» (the Russian version of the questionnaire «Assessing Risk and Criminal Needs in Youthful Offenders ― RNA»). 44 adolescents were examined, of whom 20 (45.5%) led a sober lifestyle, while in 24 people (54%) addictive behavior was diagnosed. It was found that, in adolescents with high genetic risk, addictive behavior occurs after the impact of a smaller amount of negative microsocial factors. It is recommended to use genotyping, with the aim to improve the accuracy of preventive interventions for adolescents.

Key words: addictive behavior, adolescents, genetic risk, dopamine, microsocial factors.

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