Inflammatory bowel disease and thromboembolic complications: new problem
A.Kh. RAMAZANOVA1,2, I.G. MUSTAFIN2, A.Kh. ODINTSOVA1, L.R. SADYKOVA1
1Republican Clinical Hospital of the MH of RT, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064
2Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012
Ramazanova A.Kh. — doctor of the gastroenterology department, postgraduate student of the Department of Biochemistry, tel. +7-927-404-74-40, e-mail: alsuramazan@mail.ru
Mustafin I.G. — D. Med. Sc., Head of the Department of Biochemistry, Vice Rector for Research, tel. (843) 236-28-89, e-mail: biochemistry2013@mail.ru
Odintsova A.Kh. — Cand. Med. Sc., Head of the gastroenterology department, tel. +7-927-404-74-40, e-mail: odincovaa@yandex.ru
Sadykova L.R. — doctor of the gastroenterology department, tel. (843) 237-36-27, e-mail: alsuramazan@mail.ru
This article presents the prevalence and problem of hypodiagnosis of thromboembolic complications (TC) in patients with ulcerative colitis and Crohn’s disease. The main risk factors for TC by patients with inflammatory bowel disease (IBD) were observed. Certain aspects of TC pathogenesis are procoagulant and anticoagulant disbalance of the hemostatic system. The dual role of pathological hypercoagulation in IBD was also considered — participate in the pathogenesis of the disease and genesis of thromboembolic events (TE), which significantly increase the mortality of patients. TE in IBD patients are significantly aggravates the course of the disease, management of this group of patients is a certain clinical problem.
Key words: inflammatory bowel disease, thromboembolic complications, thromboembolic events, hypercoagulability.
REFERENCES
- Owczarek D., Cibor D., Głowacki M. et al. Inflammatory bowel disease: epidemiology, pathology and risk factors for hypercoagulability. World J. Gastroenterol, 2014, vol. 20, no. 1, pp. 33-63.
- Zezos P., Kouklakis G., Saibil F. Inflammatory bowel disease and thromboembolism. World J. Gastroenterol, 2014, vol. 20, no. 38, pp. 13863-13878.
- Yoshida H., Granger D.N. Inflammatory bowel disease: a paradigm for the link between coagulation and inflammation. Inflamm Bowel Dis, 2009, vol. 15, pp. 1245-1255.
- Talbot R.W., Heppell J., Dozois R.R., Beart R.W. Jr. Vascular complications of inflammatory bowel disease. Mayo Clin Proc, 1986, vol. 61, pp. 140-145.
- Graef V., Baggenstoss A.H., Sauer W.G., Spittel J.A. Jr. Venous thrombosis in non-specific ulcerative colitis. A necropsy study. Arch Intern Med, 1965, vol. 117, pp. 377-382.
- Danese S., Papa A., Saibeni S., Repici A., Malesci A., Vecchi M. Inflammation and coagulation in inflammatory bowel disease: The clot thickens. Am J Gastroenterol, 2007, vol. 102, pp. 174-186.
- Wakefield A.J., Sawyerr A.M., Dhillon A.P., Pittilo R.M., Rowles P.M., Lewis A.A., Pounder R.E. Pathogenesis of Crohn’s disease: multifocal gastrointestinal infarction. Lancet, 1989, vol. 2, pp. 1057-1062.
- Dhillon A.P., Anthony A., Sim R., Wakefield A.J., Sankey EA., Hudson M., Allison M.C., Pounder R.E. Mucosal capillary thrombi in rectal biopsies. Histopathology, 1992, vol. 21, pp. 127-133.
- Scaldaferri F., Lancellotti S., Pizzoferrato M., De Cristofaro R. Haemostatic system in inflammatory bowel diseases: new players in gut inflammation. World J. Gastroenterol, 2011, vol. 17, pp. 594-608.
- Tsiolakidou G., Koutroubakis I.-E. (2008) Thrombosis and inflammatory bowel disease-the role of genetic risk factors. World J Gastroenterol: 14, pp. 28. 4440-4444 Jul.
- Jackson L.M., O’Gorman P.J., O’Connell J. et al. Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. Q.J.M, 1997, vol. 9, pp. 183-188.
- Danese S., Papa A., Saibeni S., Repici A., Malesci A., Vecchi M. Inflammation and coagulation in inflammatory bowel dis-ease: The clot thickens. Am J Gastroenterol., 2007, vol. 102, pp. 174-186.
- O’Connor O.J., Cahill R.A., Kirwan W.O., Redmond H.P. The incidence of postoperative venous thrombosis among patients with ulcerative colitis. Ir J Med Sci, 2005, vol. 174, pp. 20-22. [PubMed]
- Merrill A., Millham F. Increased risk of postoperative deep vein thrombosis and pulmonary embolism in patients with inflammatory bowel disease: a study of National Surgical Quality Improvement Program patients. Arch Surg, 2012, vol. 147, pp. 120-124. [PubMed]
- Wallaert J.B., De Martino R.R., Marsicovetere P.S., Goodney P.P., Finlayson S.R., Murray J.J., Holubar S.D. Venous thromboembolism after surgery for inflammatory bowel disease: are there modifiable risk factors? Data from ACS NSQIP. Dis Colon Rectum, 2012, vol. 55, pp. 1138-1144. [PMC free article] [PubMed]
- Chande N., McDonald J.W., Macdonald J.K. et al. Unfractionated or low-molecular weight heparin for induction of remission in ulcerative colitis. Cochrane Database Syst Rev, 2010, vol. 6(10).
- Tan V.P., Chung A., Yan B.P., Gibson P.R. Venous and arterial disease in inflammatory bowel disease. J Gastroenterol Hepatol, 2013, vol. 28, pp. 1095-1113.
- Van Assche G., Dignass A., Bokemeyer B., Danese S., Gionchetti P., Moser G., Beaugerie L., Gomollón F., Häuser W., Herrlinger K. et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations. J Crohns Colitis, 2013, vol. 7, pp. 1-33.


