L.R. MUKHAMEDZHANOVA^1,2, Zh.I. KUZMINA³, Yu.A. TYURIN^3,4, R.G. KUZNETSOVA⁵

¹Chuvash State University named after I.N. Ulyanov, 15 Moskovskiy Prospekt, Cheboksary, Russian Federation, 428015

²«Exclusive-Dent» Training Center, 42 Kosmonavtov St., Kazan, Russian Federation, 420061

³Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012

⁴Kazan Research Institute of Epidemiology and Microbiology, 67 Bolshaya Krasnaya St., Kazan, Russian Federation, 420015

⁵Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, 138 Orenburgskiy Trakt, Kazan, Russian Federation, 420064 

Mukhamedzhanova L.R. — D. Med. Sc., Professor of the Department of Propaedeutics of Stomatologic Diseases and New Technologies, tel. +7-965-597-11-64, e-mail: lr71@bk.ru

Kuzmina Zh.I. — postgraduate student of the Department of Therapeutic Dentistry, tel. +7-917-292-80-14, e-mail: zhannochka-kuzka@mail.ru
Tyurin Yu.A. — Cand. Med. Sc., Associate Professor, Head of the Department of Immunology, tel. +7-903-314-07-02, e-mail: laboratory immunological immunolab@yandex.ru

Kuznetsova R.G. — Senior Research of Scientific-Research Department, tel. (843) 237-34-47, e-mail: rokuz@mail.ru

This article presents the results of comparative assessment of the immunological status of Olympic reserve athletes, depending on the presence of inflammatory periodontal diseases. The effectiveness of the immunomodulatory effects of Ribomunil and Maksilak is shown, based on the dynamics of secretory immunoglobulin A and cytokine profile of oral fluid.

Key words: secretory immunoglobulin A, cytokine profile, saliva, Olympic reserve athletes, immunocorrective therapy.

REFERENCES

1. Antonova I.N. et al. Chronic stress in athletes, periodontal disease and alterations in the immune system. Meditsinskaya immunologiya, 2007, vol. 9, no. 2-3, pp. 294-295 (in Russ.).

2. Trishchenkova S.N., Arkhipova S.V., Krayushkina N.A. Changes of local immunity of the pharynx at young hockey players in the treatment of chronic tonsillitis. Fundamental’nye issledovaniya, 2012, no. 2 (part 2), pp. 377-380 (in Russ.).

3. Simon P., Fehrenbach E., Niess A.M. Regulation of immediate early gene expression by exercise: short cuts for the adaptation of immune function. Exerc. Immunol. Rev., 2006, vol. 12, pp. 112-131.

4. Mal’tseva A.B. Dinamika pokazateley sostoyaniya zdorov’ya, kachestva zhizni i organizatsiya meditsinskoy pomoshchi sportsmenam vysshey kvalifikatsii: avtoref. … kand. med. nauk [Dynamics of health status, quality of life and organization of medical care to athletes of the highest qualification. Synopsis of dis. PhD med. Sci.]. Moscow, 2009. 23 p.

5. Rozanov N.N., Levin M.Ya. Sravnitel’nyy analiz nespetsificheskoy zashchity rotovoy polosti u predstaviteley raznykh vidov sporta [Comparative analysis of nonspecific protection of the oral cavity in representatives of different sports]. Sb. tezisov mezhdunarod. nauchno-praktich. konf. “Fundamental’nye i prikladnye problemy stomatologii”. Saint Petersburg, 2009. P. 44.

6. Khaitov R.M., Martynov A.I., Il’ina N.I., Luss L.V., Tsarev S.V., Shartanova N.V., Zelenskaya N.A. Diagnostika, monitoring i korrektsiya immunodefitsitnykh sostoyaniy u vysokokvalifitsirovannykh sportsmenov: Metodicheskie rekomendatsii [Diagnostics, monitoring and correction of immunodeficiency states of elite athletes: Guidelines]. Moscow: FMBA, 2012. 40 p.

7. Kogan O.S. Nedopingovye recovery tools in the sphere of sports. Teoriya i praktika fizicheskoy kul’tury, 2005, no. 1, pp. 78-81 (in Russ.).

8. Rozanov N.N. Features of inflammatory periodontal diseases in representatives of different sports. Parodontologiya, 2009, no. 4 (53), pp. 42-45 (in Russ.).

9. Timmons B.W., Cieslak T. Human natural killer cell subsets and acute exercise: a brief review. Exerc. Immunol. Rev., 2008, vol. 14, pp. 8-23.

10. Frolova L.B. Kliniko-immunologicheskoe obosnovanie kompleksa lechebnykh meropriyatiy u patsientov s bystroprogressiruyushchim parodontitom: avtoref. … kand. med. nauk [Clinical and immunological study of the complex therapeutic interventions in patients with rapidly progressive periodontitis. Synopsis of dis. PhD med. Sci.]. Kazan, 2010. 20 p.

11. Wang J.S., Chung Y., Chow S.E. Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell. Med. Sci. Sports Exerc., 2009, vol. 41, no. l, pp. 115-122.