M.M. BIKBOV¹, I.I. KHUSNITDINOV¹, R.R. VILDANOVA², S.S. OSTAKHOV², R.R. KAYUMOVA², N.N. SIGAEVA²

¹Ufa Scientific-Research Institute for Eye Diseases of the Academy of Sciences of the Republic of Bashkortostan, 90 Pushkin Str., Ufa, Russian Federation, 450008

²Ufa Institute for Chemistry of the Russian Academy of Sciences, 71 Oktyabrya Pr., Ufa, Russian Federation, 450054

 Bikbov M.M. ― D. Med. Sc., Professor, Director, tel. (347) 272-37-75, e-mail: niipriem@yandex.ru

Khusnitdinov I.I. ― Cand. Med. Sc., Head of the 2^nd Microsurgical Department, e-mail: husnitdinov.ilnu@mail.ru

Vildanova R.R. ― Cand. Chem. Sc., Junior Researcher of the Laboratory of Stereoregular Polymers, e-mail: regina777@list.ru

Ostakhov S.S. ― Cand. Chem. Sc., Senior Researcher, e-mail: ostahov@anrb.ru

Kayumova R.R. ― Cand. Chem. Sc., Researcher, e-mail: regina.kayumova.86@mail.ru

Sigaeva N.N. ―  D. Chem. Sc., Professor, Leading Researcher of the Laboratory of Stereoregular Polymers, e-mail: gip@anrb.ru

The article presents the results of application of the developed hydrogel as a Lucentis carrier in glaucoma surgeries. Experimental studies were carried out on 12 (12 eyes) healthy rabbits. In vitro and in vivo experiments proved that Lucentis, introduced in 0.1 ml of hydrogel drainage into glaucoma surgery zone, was being released gradually and inhibited the proliferation of connective tissue. The desirable concentration of Lucentis was found to be 0.02 ml in 0.1 ml of gel.

Key words: hydrogels, Lucentis, primary open-angle and refractory glaucoma.

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