Herpetic infections and inflammatory bowel diseases
G.R. FATKULLINA¹, CH.SH. GABDRAHMANOVA², S.R. DZAMUKOV¹, M.I. DZAMUKOVA¹
¹Kazan State Medical University, Kazan
²Prof. A.F. Agafonov Republican Clinical Infectious Diseases Hospital, Kazan
Contact details:
Fatkullina G.R. – Cand. Sci. (Medicine), Associate Professor of the Department of Children’s Infections
Address: 49 Butlerov Str., 420012, Kazan, tel.: +7-917-867-91-48, e-mail: ftkguzel@mail
It is well known that herpes viruses are pantropic; therefore, herpes infections have a varied clinical picture. There are studies establishing a connection between the course of inflammatory bowel diseases, the effectiveness of their treatment, and the detection of herpesvirus DNA in the mucous membrane of the colon. The article examines a case of reactivation of a chronic herpetic infection with a predominant clinical picture of colitis against the background of immunosuppression after successive coronavirus SARS-Cov-2 and rotavirus infections. Against the background of antiviral therapy, clinical improvement was noted, laboratory parameters and histological analyzes were normalized.
Key words: Inflammatory bowel diseases, immunosuppression, coronavirus infection SARS-Cov-2, herpes viruses, CMV, EBV, HHV6, recurrent infections, lymphadenopathy.
REFERENCES
- Ivashkin V.T., Shelygin Yu.A., Abdulganieva D.I., Abdulkhakov R.A. Rekomendatsii Rossiyskoy gastroenterologicheskoy assotsiatsii i Assotsiatsii koloproktologov Rossii po diagnostike i lecheniyu vzroslykh bol’nykh yazvennym kolitom [Recommendations of the Russian Gastroenterological Association and the Association of Coloproctologists of Russia for the diagnosis and treatment of adult patients with ulcerative colitis].
- M’Koma A.E. Inflammatory bowel disease: an expanding global health problem. Clin. Med. Insights. Gastroenterol., 2013, vol. 6: 33–47.
- Farrokhyar F., Swarbick E. T., Irvine E. J. A critical review of epidemiological studies in inflammatory bowel disease. Scand J Gastroenterol., 2001; 36(1):2-15.
- Sandborn W.J., Feagan B.G., Hanauer S.B. et al. A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease. Gastroenterology, 2002; 122: 512–30.
- Global’nye prakticheskie rekomendatsii Vsemirnoy Gastroenterologicheskoy Organizatsii [Global practical recommendations of the World Gastroenterological Organization].
- Marchal J., Hilsden R. Environment and epidemiology of inflammatory bowel disease. In: Inflammatory bowel disease. Churchill Livingstone, 2003:17-28.
- Gastroenterologiya. Natsional’noe rukovodstvo, pod red. V.T. Ivashkina, T.L. Lapinoy [Gastroenterology. National Leadership, edited by Ivashkin V.T., Lapina T.L.]. Moscow: GEOTAR Media, 2008.
- Scaldaferri F., Fiocchi C. Inflammatory bowel disease: progress and current concepts of etiopathogenesis. J. Dig. Dis., 2007, vol. 8, no. 4, pp. 171–178.
- Valuyskikh E.Yu., Svetlova I.O., Kurilovich S.A. et al. linical and genetic aspects of inflammatory bowel diseases. Rossiyskiy zhurnal gastroenterologii, gepatologii i koloproktologii, 2008, vol. 18, no. 6, pp. 68–74 (in Russ.).
- Lawlor G., Moss A.C. Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander. Inflamm Bowel Dis., 2010;16(9):1620–7.
- Weinberg I., Neuman T., Margalit M. et al. Epstein-Barr virus-related diarrhea or exacerbation of inflammatory bowel disease: diagnostic dilemma. J Clin Microbiol., 2009 ;47(5):1588–90.
- Sura R., Gavrilov B., Flamand L. et al. Human herpesvirus-6 in patients with Crohn’s disease. APMIS, 2010;118(5):394–400.
- Sipponen T., Turunen U., Lautenschlager I. et al. Human herpesvirus 6 and cytomegalovirus in ileocolonic mucosa in inflammatory bowel disease. Scand J Gastroenterol., 2011;46(11):1324–33.
- Fatkullina G.R., Anokhin V.A., Khasanova G.R. Ring-shaped erythema and herpetic infections in children. Rossiyskiy vestnik perinatologii i pediatrii 2021; 66: (5): 207–212 (in Russ.).
- Fatkullina G.R., Anokhin V.A., Sabitova A.M. Figured erythema and herpetic infections in children. Rossiyskiy vestnik perinatologii i pediatrii, 2022; 67: (5): 203–210 (in Russ.).
- Sorokina E.V. Erythema annular centrifugal Darier associated with the activation of chronic infection caused by viruses of the Herpesviridae family. Klinicheskaya dermatologiya i venerologiya, 2012: 6: 33-38 (in Russ.).
- Masyukova S.A., Sorokina E.V. Features of the etiopathogenesis of erythema annular centrifugal Daria. Vrach, 2011: 1: 24-27 (in Russ.).
- Akhtar N., Khurshid Wani A., Kant Tripathi S. et al. The role of SARS-CoV-2 immunosuppression and the therapy used to manage COVID-19 disease in the emergence of opportunistic fungal infections: A review. Curr Res Biotechnol., 2022;4:337-349. doi: 10.1016/j.crbiot.2022.08.001. Epub 2022 Aug 3. PMID: 35942223; PMCID: PMC9347179.