T.Z. KERIMOV¹, S.A. BORZENOK^1,2, N.A. GAVRILOVA¹, Kh.D. TONAEVA²

¹A.I. Evdokimov Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya Str., Moscow, Russian Federation, 127473

²S. Fyodorov Eye Microsurgery Federal State Institution, 59a Beskudnikovsky Blvd., Moscow, Russian Federation, 127486

 Contact:

Kerimov T.Z. — postgraduate student of the Ophthalmology Department, tel. (499) 488-85-02, e-mail: timkerimov2014@yandex.ru

Borzenok S.A. ― D. Med. Sc., Academician of the Russian Academy of Natural Sciences, Professor of the Department of Eye Diseases, Head of the Center for Fundamental and Applied Biomedical Issues, tel. (499) 488-85-52, e-mail: cfo@mntk.ru

Gavrilova N.A. — D. Med. Sc., Professor, Head of the Department of Eye Diseases, tel. (499) 488-85-02, e-mail: kafedra_eye@mail.ru

Tonaeva Kh.D. — Cand. Med. Sc., Head of Eye Tissue Bank, tel. (499) 488-84-05, e-mail: dr.tonaeva@gmail.com

The article presents data on topicality, epidemiological significance, and historical aspects of herpes viral infections, as well as its characteristics, classification, means of transmission and replication. The data on reactivation are given, together with the factors promoting the activation of the latent herpes viral infection. The main modern therapy principles are described. The modern classification of interferons is given, the features of their synthesis, mechanism of action and anti-viral efficiency are described. The choronological review is presented of the main trends in studying the issue of the herpes virus transmission during cornea transplantation. The authors’ innovative technique of viral decontamination of donor corneas in eye banks is described.

Key words: herpes simplex virus type I, herpes keratitis, cornea transplantation, cornea storage, viral decontamination.

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