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  •  Headache in patients with connective tissue dysplasia

    Редактор | 2023, Literature reviews, Practical medicine part 21 №4. 2023 | 30 июля, 2023

    D.M. MANSUROV, D.KH. KHAIBULLINA

     Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, Kazan

     Contact details:

    Mansurov D.M. — post-graduate student of the Department of Neurology

    Address: 11 Mushtari St., Kazan, Russian Federation, 420012, tel.: +7-929-725-22-01, e-mail: daniarmansurov@gmail.com

     Headache in patients with connective tissue dysplasia (CTD) is an urgent problem of modern medicine. The article discusses different types of headache in patients with connective tissue dysplasia. The most well studied are differentiated forms of connective tissue dysplasia (Ehlers — Danlos syndrome, Marfan syndrome, etc.) and, accordingly, variants of cephalgia in them are described. A significant problem is the dissection of the carotid and vertebral arteries, which are variants of acute cerebrovascular accident. The interrelation of primary and secondary headaches with CTD syndrome is shown. The variety of clinical manifestations of headaches and connective tissue dysplasia in the same patient makes it difficult to diagnose, which can contribute to the chronicity of cephalalgia, the appointment of inadequate therapy and the development of complications. Further study of headache options in patients with CTD will improve the provision of medical care to this category of patients.

    Key words: headache, connective tissue dysplasia, joint hypermobility syndrome, pain, migraine, cervicogenic headache.

    REFERENCES

    1. Clinical recommendations of the Russian Scientific Medical Society of Therapists for the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia (first revision). Meditsinskiy vestnik Severnogo Kavkaza, 2018, no. 1.2 (in Russ.). DOI: 10.14300/mnnc.2018.13037
    2. Tinkle B.T., Bird H.A., Grahame R. et al. The lack of clinical distinction between the hypermobility type of Ehlers-Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome). Am J Med Genet A, 2009, vol. 149A (11), pp. 2368–2370. DOI: 10.1002/ajmg.a.33070
    3. Malfait F., Francomano C., Byers P. et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet, 2017, vol. 175 (1), pp. 8–26. DOI: 10.1002/ajmg.c.31552
    4. Castori M., Tinkle B., Levy H. et al. A. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet, 2017, vol. 175 (1), pp. 148–157. DOI: 10.1002/ajmg.c.31539
    5. Sacheti A., Szemere J., Bernstein B. et al. Chronic pain is a manifestation of the Ehlers-Danlos syndrome. J Pain Symptom Manage, 1997, vol. 14 (2), pp. 88–93. DOI: 10.1016/s0885-3924(97)00007-9
    6. Jacome D. Headache in Ehlers — Danlos Syndrome. Cephalalgia, 1999,vol. 19 (9), pp. 791–796. DOI: 10.1046/j.1468-2982.1999.1909791.x
    7. Castori M., Camerota F., Celletti C., et al. Natural history and manifestations of the hypermobility type Ehlers-Danlos syndrome: a pilot study on 21 patients. Am J Med Genet A, 2010, vol. 152A (3), pp. 556–564. DOI: 10.1002/ajmg.a.33231
    8. Henderson Sr., Austin F.C., Benzel C. et al. Neurological and Spinal Manifestations of the Ehlers-Danlos Syndromes. American Journal of Medical Genetics, vol. 175, pp. 195–211. DOI: 10.1002/ajmg.c.31549
    9. Jones J.T., Black W.R., Cogan W. Resource utilization and multidisciplinary care needs for patients with Ehlers-Danlos syndrome. Mol Genet Genomic Med, 2022, vol. 10 (11), p. 2057. DOI: 10.1002/mgg3.2057
    10. Castori M., Morlino S., Ghibellini G. et al. Connective tissue, Ehlers-Danlos syndrome(s), and head and cervical pain. Am J Med Genet C Semin Med Genet, 2015, vol. 169C (1), pp. 84–96. DOI: 10.1002/ajmg.c.3142.
    11. Walter S.M., Case Report: Ehlers-Danlos Syndrome in an adolescent presenting with Chronic Daily Headache. Surg Neurol Int, 2014, vol. 5 (13), pp. 475–478. DOI: 10.4103/2152-7806.144629
    12. Alcorn S.R., Sorel M.A., Auerbach S. et al. Ehlers — Danlos Syndrome Presenting as Severe Headache in a Young Adult. Radiol Case Rep, 2015, vol. 3 (2), p. 172. DOI: 10.2484/rcr.v3i2.172
    13. Hakim A.J., Grahame R. Non-musculoskeletal symptoms in joint hypermobility syndrome. Indirect evidence for autonomic dysfunction? Rheumatology (Oxford), 2004, vol. 43 (9), pp. 1194–1195. DOI: 10.1093/rheumatology/keh279
    14. Knudsen S., Russell M.B. Increased risk of migraine in Marfan’s syndrome? Acta Neurol Scand, 2006, vol. 114 (4), pp. 281–286. DOI: 10.1111/j.1600-0404.2006.00640.x
    15. Vis J.C., Timmermans J., Post M.C. et al. Increased prevalence of migraine in Marfan syndrome. Int J Cardiol, 2009, vol. 136 (3), pp. 330–334. DOI: 10.1016/j.ijcard.2008.05.037
    16. Koppen H., Vis J.C., Gooiker D.J. et al. Aortic root pathology in Marfan syndrome increases the risk of migraine with aura. Cephalalgia, 2012, vol. 32 (6), pp. 467–472. DOI: 10.1177/0333102412441091
    17. Bendik E.M., Tinkle B.T., Al-shuik E. et al. Joint hypermobility syndrome: A common clinical disorder associated with migraine in women. Cephalalgia, 2011, vol. 31 (5), pp. 603–613. DOI: 10.1177/0333102410392606
    18. Yazici M., Ataoglu S., Makarc S. et al. The relationship between echocardiographic features of mitral valve and elastic properties of aortic wall and Beighton hypermobility score in patients with mitral valve prolapse. Jpn Heart J, 2004, vol. 45 (3), pp. 447–460. DOI: 10.1536/jhj.45.447
    19. Puledda F., Viganò A., Celletti C. et al. A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type. Neurol Sci, vol. 36 (8), pp. 1417–1424. DOI: 10.1007/s10072-015-2173-6
    20. Martin V.T., Neilson D. Joint hypermobility and headache: the glue that binds the two together-part 2. Headache, 2014, vol. 54 (8), pp. 1403–1411. DOI: 10.1111/head.12417
    21. Volman M., Mojadidi M.K., Gevorgyan R. et al. Incidence of patent foramen ovale and migraine headache in adults with congenital heart disease with no known cardiac shunts. Catheter Cardiovasc Interv, 2013, vol. 81 (4), pp. 643–647. DOI: 10.1002/ccd.24635
    22. Gazit Y., Nahir A.M., Grahame R. et al. Dysautonomia in the joint hypermobility syndrome. Am J Med, 2003, vol. 115 (1), pp. 33–40. DOI: 10.1016/s0002-9343(03)00235-3
    23. Chuang Y.M., Hwang Y.C., Lin C.P. et al. Toward a further elucidation: role of vertebral artery hypoplasia in migraine with aura. Eur Neurol, 2008, vol. 59 (3–4), pp. 148–151. DOI: 10.1159/000111878
    24. Semenkin A.A., Drokina O.V., Nechaeva G.I., Zhivilova L.A., Zhenatov A.B. Undifferentiated connective tissue dysplasia as an independent predictor of structural and functional changes in arteries. KVTiP, 2013, no. 3 (in Russ.).
    25. Kaur S., Ali A., Pandey A.K., Singh B. Association of MTHFR gene polymorphisms with migraine in North Indian population. Neurol Sci, 2018, vol. 39 (4), pp. 691–698. DOI: 10.1007/s10072-018-3276-7
    26. Benke K., Ágg B., Pólos M. et al. The effects of acute and elective cardiac surgery on the anxiety traits of patients with Marfan syndrome. BMC Psychiatry, 2017, vol. 17 (1), p. 253. DOI: 10.1186/s12888-017-1417-9
    27. Rainero I., Vacca A., Roveta F. et al. Targeting MTHFR for the treatment of migraines. Expert Opin Ther Targets, 2019, vol. 23 (1), pp. 29–37. DOI: 10.1080/14728222.2019.1549544
    28. Castori M., Morlino S., Celletti C. et al. Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers — Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach. Am J Med Genet A, 2012, vol. 158A (8), pp. 2055–2070. DOI: 10.1002/ajmg.a.35483
    29. Beckers A.B., Keszthelyi D., Fikree A. et al. Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist. Neurogastroenterol Motil, 2017, vol. 29 (8), p. 10. DOI: 10.1111/nmo.13013
    30. Sjaastad O., Bakketeig L.S. Prevalence of cervicogenic headache: Vaga study of headache epidemiology. Acta Neurol Scand, 2008, vol. 117 (3), pp. 173–180. DOI: 10.1111/j.1600-0404.2007.00962.x
    31. Nilsson N. The prevalence of cervicogenic headache in a random population sample of 20–59 year olds. Spine (Phila Pa 1976), 1995, vol. 20 (17), pp. 1884–1888. DOI: 10.1097/00007632-199509000-00008
    32. Medvedeva L.A., Dutikova E.F., Shcherbakova N.E. et al. Complex pathogenetic therapy of headaches caused by degenerative-dystrophic changes in the cervical spine with symptoms of venous stasis. Zhurnal nevrologii i psikhiatrii im. C.C. Korsakova, 2007, vol. 107, no. 11, pp. 36–41 (in Russ.).
    33. Podchufarova E.V., Yakhno N.N. Khronicheskaya golovnaya bol’. Patogenez, klinika, lechenie: ucheb. posob. dlya vrachey [Chronic headache. Pathogenesis, clinic, treatment: textbook. allowance for doctors]. Moscow: OOO “AMA-PRESS”, 2009. P. 84.
    34. Kahkeshani K., Ward P.J. Connection between the spinal dura mater and suboccipital musculature: evidence for the myodural bridge and a route for its dissection-a review. Clin Anat, 2012, vol. 25 (4), pp. 415–422. DOI: 10.1002/ca.21261
    35. Rozen T.D., Roth J.M., Denenberg N. Cervical spine joint hypermobility: a possible predisposing factor for new daily persistent headache. Cephalalgia, 2006, vol. 26 (10), pp. 1182–1185. DOI: 10.1111/j.1468-2982.2006.01187.x
    36. Tardov M.V., Boldin A.V., Sturov N.V., Kobylyanu G.N., Freyre Da Sil’va Tiago. The place of myofascial syndrome in the genesis of headaches and facial pains. Izvestiya Rossiyskoy voenno-meditsinskoy akademii, 2022, vol. 41, no. 4, pp. 429–437 (in Russ.). DOI: 10.17816/rmmar111883
    37. Barulin A.E., Kurushina O.V., Drushlyakova A.A. Cervicogenic headache and features of spinal biomechanics. RMZh, 2016, no. 24, pp. 1606–1612 (in Russ.).
    38. Esin R.G., Esin O.R., Mukhametova E.R., Lotfullina N.Z. Syndromes of central sensitization. Nevrologicheskiy vestnik, 2013, vol. 45, no. 3, pp. 64–70 (in Russ.).
    39. Tabeeva G.R., Katsarava Z. Modern concept of pathophysiology and new targets for migraine therapy. Nevrologiya, neyropsikhiatriya, psikhosomatika, 2020, no. 12 (4), pp. 143–152 (in Russ.). DOI: 10.14412/2074-2711-2020-4-143-152
    40. Tyan K.V., Kalinskiy P.P. Significance of brain-derived neurotrophic factor (BDNF) in the pathogenesis of chronic tension-type headache. Rossiyskiy zhurnal boli, 2020, no. 18 (2), pp. 5–8 (in Russ.). DOI: 10.17116/pain2020180215
    41. Moskaleva P.V., Khramchenko M.A., Karpenkova A.D. et al. Modern ideas about the pathogenesis of tension headache and the mechanisms of development of the phenotype «tension headache and arterial hypertension». Rossiyskiy nevrologicheskiy zhurnal, 2022, vol. 27, no. 2, pp. 22–33 (in Russ.). DOI: 10.30629/2658-7947-2022-27-2-22-33
    42. Furquim B.D., Flamengui L.M., Conti P.C. TMD and chronic pain: a current view. Dental Press J Orthod, 2015, vol. 20 (1), pp. 127–133. DOI: 10.1590/2176-9451.20.1.127-133.sar
    43. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 2013, vol. 33 (9), pp. 629–808. DOI: 10.1177/0333102413485658
    44. Gonçalves D.A., Camparis C.M., Speciali J.G. et al. Temporomandibular disorders are differentially associated with headache diagnoses: a controlled study. Clin J Pain, 2011, vol. 27 (7), pp. 611–615. DOI: 10.1097/AJP.0b013e31820e12f5
    45. Likhachev S.A., Astapenko A.V., Terekhov V.S. et al. Spontaneous intracranial hypotension (clinical observations and literature review). Nevrologiya i neyrokhirurgiya. Vostochnaya Evropa, 2021, vol. 11, no. 3, pp. 368–376 (in Russ.). DOI 10.34883/PI.2021.11.3.049
    46. Mokri B., Maher C.O., Sencakova D. Spontaneous CSF leaks: underlying disorder of connective tissue. Neurology, 2002, vol. 58 (5), pp. 814–816. DOI: 10.1212/wnl.58.5.814
    47. Schievink W.I., Gordon O.K., Tourje J. Connective tissue disorders with spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension: a prospective study. Neurosurgery, 2004, vol. 54 (1), pp. 65–71. DOI: 10.1227/01.neu.0000097200.18478.7b
    48. Schievink W.I., Meyer F.B., Atkinson J.L. et al. Spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension. J Neurosurg, 1996, vol. 84 (4), pp. 598–605. DOI: 10.3171/jns.1996.84.4.0598
    49. Mokri B., Piepgras D.G., Miller G.M. Syndrome of orthostatic headaches and diffuse pachymeningeal gadolinium enhancement. Mayo Clin Proc, 1997, vol. 72 (5), pp. 400–413. DOI: 10.4065/72.5.400
    50. Liu F.C., Fuh J.L., Wang Y.F., Wang S.J. Connective tissue disorders in patients with spontaneous intracranial hypotension. Cephalalgia, 2011, vol. 31 (6), pp. 691–695. DOI: 10.1177/0333102410394676
    51. Puget S., Kondageski C., Wray A., et al. Chiari-like tonsillar herniation associated with intracranial hypotension in Marfan syndrome. Case report. J Neurosurg, 2007, vol. 106 (1), pp. 48–52. DOI: 10.3171/ped.2007.106.1.48
    52. Milhorat T.H., Bolognese P.A., Nishikawa M., et al. Syndrome of occipitoatlantoaxial hypermobility, cranial settling, and Chiari malformation type I in patients with hereditary disorders of connective tissue. J Neurosurg Spine, 2007, vol. 7, pp. 601–609. DOI: 10.3171/SPI-07/12/601
    53. Kalashnikova L.A., Dobrynina L.A., Maksimova M.Yu. et al. Dissection of the internal carotid and vertebral arteries: tactics of patient management. Annaly klinicheskoy i eksperimental’noy nevrologii, 2021, vol. 5 (1), pp. 5–12. DOI: 10.25692/ACEN.2021.1.1
    54. Dittrich R., Rohsbach D., Heidbreder A. et al. Mild mechanical traumas are possible risk factors for cervical artery dissection. Cerebrovasc Dis, 2007, vol. 23 (4), pp. 275–281. DOI: 10.1159/000098327
    55. Haldeman S., Kohlbeck F.J., McGregor M. Risk factors and precipitating neck movements causing vertebrobasilar artery dissection after cervical trauma and spinal manipulation. Spine (Phila Pa 1976), 1999, vol. 24 (8), pp. 785–794. DOI: 10.1097/00007632-199904150-00010
    56. Pepin M., Schwarze U., Superti-Furga A. et al. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type. N Engl J Med, 2001, vol. 344 (5), p. 392. DOI: 10.1056/NEJM200003093421001
    57. Brandt K.D., Sumner R.D., Ryan T.J., Cohen A.S. Herniation of mitral leaflets in the Ehlers-Danlos syndrome. Am J Cardiol, 1975, vol. 36 (4), pp. 524–528. DOI: 10.1016/0002-9149(75)90906-6
    58. Brandt T., Orberk E., Weber R. et al. Pathogenesis of cervical artery dissections: association with connective tissue abnormalities. Neurology, 2001, vol. 57 (1), pp. 24–30. DOI: 10.1212/wnl.57.1.24
    59. Ulbricht D., Diederich N.J., Hermanns-Lê T. et al. Cervical artery dissection: An atypical presentation with Ehlers-Danlos-like collagen pathology? Neurology, 2004, vol. 63 (9), pp. 1708–1710. DOI: 10.1212/01.wnl.0000142970.09454.30
    60. Brandt T., Hausser I., Orberk E. et al. Ultrastructural connective tissue abnormalities in patients with spontaneous cervicocerebral artery dissections. Ann Neurol, 1998, vol. 44 (2), pp. 281–285. DOI: 10.1002/ana.410440224
    61. Uhlig P., Bruckner P., Dittrich R. et al. Aberrations of dermal connective tissue in patients with cervical artery dissection (sCAD). J Neurol, 2008, vol. 255 (3), pp. 340–346. DOI: 10.1007/s00415-008-0585-4

    Метки: 2023, cervicogenic headache, connective tissue dysplasia, D.KH. KHAIBULLINA, D.M. MANSUROV, headache, joint hypermobility syndrome, migraine, pain, Practical medicine part 21 №4. 2023

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