Giardiasis in children with diabetes mellitus type 1
A.A. NIZHEVICH1, G.M. YAKUPOVA1,2, O.O. MALIYEVSKIY1, A.M. FARKHUTDINOVA2, E.N. AKHMADEYEVA1, V.U. SATAYEV1, D.S. NURMUKHAMETOVA2
1Bashkir State Medical University, 3 Lenin St., 450000 Ufa, Russian Federation
2Republican Children’s Clinical Hospital, 98 Stepana Kuvykina St., 450106 Ufa, Russian Federation
NizhevichA.A. — Professor of Hospital Pediatrics Chair, tel.: +7-917-3513685, (347) 254-88-48, e-mail: aanj@yandex.ru1
Yakupova G.M. — Head of Gastroenterology Department, tel. (347) 254-88-48, e-mail: aanj@yandex.ru1,2
Maliyevskiy O.O.— DM, Professor of Hospital Pediatrics Chair, tel. +7-917-344-59-10, e-mail: malievsky@list.ru1
Farkhutdinova A.M. — PhD (Biology), doctor of Laboratory Diagnostics Department, tel. (347) 254-88-48, e-mail: aanj@yandex.ru2
Akhmadeyeva E.N. — DM, Professor, Head of Hospital Pediatrics Chair, tel. (347) 254-88-48, e-mail: pediatr@ufanet.ru1
Satayev V.U. — DM, Professor of Children’s Surgery Chair, tel. (347) 254-88-48, e-mail: aanj@yandex.ru1
Nurmukhametova D.S. — PhD (Medicine), Head of Endocrinology Department, tel. +7-917-4259150, e-mail: nurmukhametovad@mail.ru2
59 children of 5 to 13 years of age with diabetes mellitus type 1 were examined. Giardiasis was found in 43 children (72.9%), including 15 patients (34.8%) with a high degree of invasion. 41 patients with giardiasis (95.3%) showed endoscopic signs of chronic duodenitis, while 37 children (86.0%) showed signs of Oddi sphincter dysfunction of pancreatic type. The screening for giardiasis should be performed to all patients with diabetes mellitus with dyspeptic syndrome.
Key words: diabetes mellitus, giardiasis, frequency, diagnostics.
REFERENCES
1. Suntsov Yu.I., Bolotskaya L.L., Maslova O.V., Kazakov I.V. Epidemiology and prognosis of diabetes prevalence in the Russian Federation. Sakharnyy diabet, 2011, no. 1, pp. 11-18 (in Russ.).
2. Zhukov N.A., Styrt E.A., Kononov A.V. Features of Helicobacter-associated gastritis in diabetes. Razvitie idey akademika V.Kh. Vasilenko v sovremennoy gastroenterologii [Developing ideas of Academician V.Kh. Vasilenko in modern gastroenterology]. Moscow, 1993. PP. 137-139.
3. Voronin A.A., Taranenko L.A., Sidorenko S.V. Treatment of intestinal dysbiosis in children with DM. Antibiotiki i khimioterapiya, 1999, vol. 44, no. 3, pp. 22-24 (in Russ.).
4. Gardner T., Hill D. Treatment of giardiasis. Clin. Microbiol. Rev, 2001, vol. 114, no. 1, pp. 114-128.
5. Ortiz J., Ayoub A., Gargala G. et al. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis iu children from Northern Peru. Aliment. Pharmacol. Ther, 2001, vol. 15, pp. 1409-1415.
6. Kornienko E.A., Minina S.N., Fedina S.A., Loboda T.B. Clinical features, diagnosis and treatment of giardiasis in children. Pediatricheskaya farmakologiya, 2001, vol. 6, no. 4, pp. 2-7 (in Russ.).
7. Akhmetova R.A., Tupertseva G.T., Moskvicheva E.O., Akhmetov R.T. Lyamblioznaya invaziya u detey s khronicheskimi boleznyami organov pishchevareniya [Lyamblioznaya infestation in children with chronic diseases of the digestive system]. Ufa, 2011. 124 p.
8. Khusid I.L. Rol’ parazitarnoy sensibilizatsii v formirovanii allergozov u detey: avtoref. dis. … kand. med. nauk [Role in the formation of parasitic sensitization allergies in children. Synopsis of the dis. of PhD med. sci]. Perm, 2000. 24 p.
9. Hakim G., Kiziltas S., Ciftci H. et al. The prevalence of giardia intestinalis in dyspeptic and diabetic patients. Intern. Sholar. Res. Network, 2011. ID 580793, 4 p; doi: 10.5402/2011/580793.
10. Matveeva O.V. Morfofunktsional’nye osobennosti slizistoy obolochki zheludochno-kishechnogo trakta u detey pri lyamblioznoy invazii: avtoref. dis. … kand. med. nauk [Morphological and functional features of the mucous membrane of the gastrointestinal tract in children with lyamblioznoy invasion. Synopsis of the dis. of PhD med. sci]. Saratov, 2013. 24 p.
11. Rumyantseva I.V., Privorotskiy V.F., Krasnovskaya M.A. Early diagnosis of functional changes of the pancreas in children. Aktual’nye problemy pediatrii i detskoy nevrologii [Actual problems of pediatrics and pediatric neurology]. Saint Petersburg, 1996. PP. 119-124.
12. Vesy C., Peterson W.L. Review article: the management of giardiasis. Aliment. Pharmacol. Ther, 1999, vol. 13, pp. 843-850.
13. Nizhevich A.A., Yakupova G.M., Shakhmaeva T.M. et al. Dysfunction of the sphincter of Oddi by pancreatic type in children: solved and unsolved questions, approaches to treatment. Voprosy detskoy dietologii, 2008, vol. 6, no. 2, pp. 11-16 (in Russ.).
14. Gubergrits N.B., Zagorenko Yu.A., Golubova O.A. et al. Defeat pancreatic simplest. Vnutrennyaya meditsina, 2008, no. 2, pp. 71-74 (in Russ.).
15. Nakano I., Miyahara T., Ito T. et al. Giardiasis in pancreas. Lancet, 1995, vol. 345, no. 8948, pp. 524-525.
16. Grouls V., Seidl C. Massive duodenal lambliasis and Helicobacter heilmannii gastritis in a diabetic patient. Dtsch. Med. Wochenschr, 1999, vol. 124, no. 19, p. 611.
17. Miyahara T., Kubokawa M., Koyanagi S. et al. A case of successfully treated giardiasis in pancreas. Fukuoka Igaku Zasshi, 1997, vol. 88, no. 9, pp. 313-318.
18. Edling L., Rathsman S, Eriksson S., Bohr J. Celiac disease and giardiasis: a case report. Eur. Gastroenterol. Hepatol, 2012, vol. 24, no. 8, pp. 984-987.