I.E. KRAVCHENKO¹, Ch.Ch. EMENE², A.A. RIZVANOV²

¹Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan

²Kazan (Volga) Federal University, Kazan

Contact:

Kravchenko I.E. ― MD, Professor of the Department of Infectious Diseases

Address: 49 Butlerov Str., Kazan, Russian Federation, 420012, tel. +7-906-320-16-86, e-mail: kravchencoie@mail.ru

The aim is to study the role of polymorphism of genes of enzymes of the antioxidant system in the development of erysipelas and characteristics of the clinical course of the disease.

Material and methods. The main group ― 92 patients with erysipelas, the control group ― 71 healthy individuals. In the DNA extracted from venous blood, four single-nucleotide polymorphisms (SNPs) of two AOS enzyme genes — superoxide dismutase and catalase — SOD1 G7958A, SOD2 (C2734T), SOD2 C60T, and CAT C-262T were determined using diagnostic kits of CJSC Litekh, Russia. The study presents a comparative analysis of the distribution of gene polymorphisms of antioxidant system enzymes (AOS) in the group of patients with erysipelas and the group of relatively healthy individuals living in the Republic of Tatarstan.

The results of the study showed that gene polymorphisms of the enzymes superoxide dismutase 1 — SOD1 (G7958A), superoxide dismutase 2 — SOD2 (T2734C) and catalase — CAT (C262T) affect the susceptibility to the development of erysipelas and the clinical features of the disease.

Key words: erysipelas, antioxidant system, gene polymorphism, catalase (CAT), superoxide dismutase (SOD).

(For citation: Kravchenko I.E., Emene Ch.Ch., Rizvanov A.A. Genetic features of the antioxidant system in patients with erysipelas and their role in development of the disease. Practical medicine. 2019. Vol. 17, №8, P. 48-53)

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