O.V. Alpidovskaya¹, S.A. Markova¹, N.N. Lantsova¹, L.P. Romanova¹

¹Chuvash State University named after I.N. Ulyanov, Cheboksary

Contact details:

Alpidovskaya O.V. — PhD (Medicine), Associate Professor, Department of General and Clinical Morphology and Forensic Medicine

Address: 15 Moskovsky Prospekt, 428015 Cheboksary, Russian Federation, tel.: +7-927-858-05-18, e-mail: olya-vorobeva-2018@mail.ru

 The purpose — to describe a case of organ toxoplasmosis in a patient with Nijmegen syndrome after COVID-19 infection.

Results. Patient P.A., 22 y. o., was admitted on August 19, 2025, complaining of a fever of 38.4°C and a cough. He also reported headaches and occasional dizziness. An ambulance was called due to seizures. The patient suffered COVID-19 in June 2025; the disease was mild. Outpatient tests for TORCH infection were negative. Past medical history: Nijmegen syndrome was diagnosed in adolescence. Complete blood count: Leukocytes: 6.2 × 109/L, Percentage: Neutrophils: 41.5%, Eosinophils: 17%. Diagnostic criteria for toxoplasmosis were based on CT scans of the brain and lungs, combined with an ELISA test for IgG antibodies to toxoplasmosis (positive). Symptomatic therapy was initiated. A sudden fatal outcome developed. Autopsy revealed areas of necrosis in the brain and lung tissue, scattered bacterial flora, Toxoplasma pseudocysts, and perivascular «muff-shaped» lymphoid infiltration.

Conclusion. Based on the case, one can assume that patients with immunodeficiency may experience complications after COVID-19 infection.

Key words: Toxoplasma gondii, Nijmegen syndrome, COVID-19, brain, lungs.

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