Features of walking disorders in multiple sclerosis
A.D. DOROKHOV1, G.G. SHKILNYUK1, Т.L. TSVETKOVA2, I.D. STOLIAROV1
1Bechtereva Institute of the Human Brain of the Russian Academy of Sciences, St. Petersburg
2 Novel SPb Corp., St. Petersburg
Contact details:
Dorokhov A.D. — postgraduate student
Address: 9 Akademika Pavlova Str., St. Petersburg, Russian Federation, 197376, tel.: +7-951-666-95-99, e-mail: dorohovart@yandex.ru
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system, affecting persons of young working age and quickly leading them to disability, accompanied by motor disorders. Movement disorders lead to changes in gait, which can be quantified using a variety of techniques.
The purpose — to study the current literature data on pathogenetic mechanisms of development and clinical features of motor disorders in multiple sclerosis, to compare different methods of walking disorders assessment depending on the forms and degree of multiple sclerosis development.
Material and methods. To assess walking disorders, several dozen different techniques are used, which allow estimating the spatial and temporal characteristics of gait. In this review, MS severity was compared with gait parameters using standardized walking assessment methods. Gait examination has important diagnostic value, and also allows observing the course of MS. The simplest tests that do not require special equipment show only the time characteristics of gait. The use of special tracks for gait assessment with data analysis through software shows the temporal and spatial parameters of gait.
Conclusion. The study of gait in multiple sclerosis allows evaluating the subtle, including pre-clinical, manifestations of MS. However, the problem of walking disorders according to literature sources is not fully disclosed, which requires a comprehensive study in this area.
Key words: multiple sclerosis, gait impairment, walking disorders in multiple sclerosis, gait estimation methods.
(For citation: Dorokhov A.D., Shkilnyuk G.G., Tsvetkova Т.L., Stoliarov I.D. Features of walking disorders in multiple sclerosis. Practical Medicine. 2019. Vol. 17, № 7, P. 28-32)
REFERENCES
- Stolyarov I.D., Osetrov B.A. Rasseyannyĭ skleroz [Multiple sclerosis]. Saint Petersburg: LBI-SPb, 2002. 176 p.
- Kurtzke J.F. Neurology rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983, vol. 33.
- Barabanova M.A., Ivanova E.M., Stoyanova O.V. et al. Neurology rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Kubanskiy nauchno-meditsinskiy vestnik, 2012, no. 5, p. 134 (in Russ.).
- Givon U., Zeilig G., Achiron A. Gaitanalysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture, 2009, vol. 29, p. 138.
- Pau M., Mandaresu S., Pilloni G.et al. Smoothness of gait detects early alterations of walking in persons with multiple sclerosis without disability. Gait Posture, 2017, vol. 58, pp. 307–309.
- Kahraman T., Savci S., Coskuner Poyraz E. et al. Utilization of the Expanded Disability Status Scale as a distinctive instrument for walking impairment in persons with multiple sclerosis with mild disability. NeuroRehabilitation, 2016, vol. 38, pp. 7–14.
- Kalron A., Givon U. Gait characteristics according to pyramidal, sensory and cerebellar EDSS subcategories in people with multiple sclerosis. J Neurol, 2016, vol. 263, P. 9.
- Abou Zeid N.E., Weinshenker B.G., Keegan B.M. Gaitapraxia inmultiple sclerosis. Can J Neurol Sci, 2009, vol. 36, p. 562.
- Odinak M.M., Dyskin D.E. Klinicheskaya diagnostika v nevrologii [Clinical diagnosis in neurology]. SpetsLit, 2007. 525 p.
- Shmidt T.E., Yakhno N.N. Rasseyannyy skleroz [Multiple sclerosis]. Moscow: Medpress-inform. 2010. Pp. 54–57.
- Motl R.W., Learmonth Y.C. Neurological disability and its association with walking impairment in multiple sclerosis: brief review. Neurodegener Dis Manag, 2014, vol. 4, pp. 491–500.
- Kohn C.G., Coleman C.I., Michael White C. et al. Mobility, walking and physical activity in persons with multiple sclerosis. Curr Med Res Opin, 2014, vol. 30, p. 9.
- Feys P., Bibby B.M., Baert I., Dalgas U. Walking capacity and ability are more impaired in progressive compared to relapsing type of multiple sclerosis. Eur J PhysRehabil Med, 2015, vol. 51, p. 207.
- Langeskov-Christensen D., Feys P., Baert I. et al. Performed and perceived walking ability in relation to the Expanded Disability Status Scale in persons with multiple sclerosis. J Neurol Sci, 2017, vol. 15, pp. 131–136.
- Bollaert R.E., Poe K., Hubbard E.A. et al. Associations of functional connectivity and walking performance in multiple sclerosis. Neuropsychologia, 2018, vol. 117, pp. 8–12.
- Leone C., Kalron A., Smedal T. et al. Effects of Rehabilitation on Gait Pattern at Usual and Fast Speeds Depend on Walking Impairment Level in Multiple Sclerosis. Int J MS Care, 2018, vol. 20, pp. 199–209.
- Grobelny A., Behrens JR., Mertens S. et al. Maximum walking speed in multiple sclerosis assessed with visual perceptive computing. PLoS One, 2017, vol. 15, p. 12.
- Behrens J., Pfüller C., Mansow-Model S. et al. Using perceptive computing in multiple sclerosis — the Short Maximum Speed Walk test. Journal of Neuroengineering and Rehabilitation, 2014, vol. 11, p. 89.
- Bethoux F., Varsanik J.S., Chevalier T.W. et al. Walking speed measurement with an Ambient Measurement System (AMS) in patients with multiple sclerosis and walking impairment. Gait Posture, 2018, vol. 61, pp. 393–397.
- Créange A., Serre I., Levasseur M. et al. Walking capacities in multiple sclerosis measured by global positioning system odometer. Mult. Scler, 2007, vol. 13, p. 220.
- Ramari C., Moraes A.G., Tauil C.B. et al. Knee flexor strength and balance control impairment may explain declines during prolonged walking in women with mild multiple sclerosis. MultSclerRelatDisord, 2018, vol. 20, p. 181.
- Hubbard E.A., Wetter N.C., Sutton B.P.et al. Diffusion tensor imaging of the corticospinal tract and walking performance in multiple sclerosis. J Neurol Sci, 2016, vol 15, p. 363.
- Sosnoff J.J., Socie M.J., Boes M.K. et al. Mobility, balance and falls in persons with multiple sclerosis. PLoS One, 2011, vol. 6, p. 11.
- Kalron A., Frid L. The “butterfly diagram”: A gait marker for neurological and cerebellar impairment in people with multiple sclerosis. J Neurol Sci, 2015, vol. 358, pp. 92–100.
- Petrov A.M., Stolyarov I.D., Shkil’nyuk G.G. et al. Dynamics of walking disorders in multiple sclerosis. Nevrologiya, neĭropsikhiatriya, psikhosomatika, 2015, vol. 1, pp. 27–32 (in Russ.).
- Paul L., Enright and Duane L. Sherrill. Reference Equations for the Six-Minute Walk in Healthy Adults. Am J Respir Crit Care Med, 1998, vol. 158, pp. 1384.
- Rudick R., Cutter G., Reingold S. The Multiple Sclerosis Functional Composite: a new clinical outcome measure for multiple sclerosis trials. Mult. Scler, 2002, vol. 8, pp. 359.
- Hobart J.C., Riazi A., Lamping D.L. et al. Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12). Neurology, 2003, vol. 60, p. 31.
- McDonough A.L., Batavia M., Chen F.C. et al. The validity and reliability of the GAITRite system’s measurements: a preliminary evaluation. Arch Phys Med Rehabil, 2001, vol. 82, p. 419.
- Cornelis J.T., van Uden and Marcus P. Besser. Test-retest reliability of temporal and spatial gait characteristics measured with an instrumented walkway system (GAITRite®). BMC Musculoskeletal Disorders, 2004, vol. 5, p. 13.
- Moon Y., McGinnis R.S., Seagers K. et al. Monitoring gait in multiple sclerosis with novel wearable motion sensors. PLoS One, 2017, vol. 12, p. 2.
- Soyuer F., Mirza M., Erkorkmaz U. Balance performance in three forms of multiple sclerosis. Neurol Res, 2006, vol. 5, p. 555.
- Stevens V., Goodman K., Rough K., Kraft G.H. Gait impairment and optimizing mobility in multiple sclerosis. Phys Med Rehabil Clin N Am, 2013, vol. 4, p. 573.