O.A. DENISOVA, K.K. EGOROVA, G.E. CHERNOGORYUK, N.V. BARANOVSKAYA, L.P. RIKHVANOV, G.M. CHERNYAVSKAYA, A.N. GOLOSCHAPOVA
Tomsk Regional Clinical Hospital
Siberian Medical University, Tomsk
National Research Tomsk Polytechnic University

The results of the study of chemical elements (Ca, Sc, Cr, Fe, Co, Zn, Br, Rb, Ag, Ba, Sr, Nd, As, Au, La, Th, U, Hf, Cs, Tb, Ta, Sm, Eu, Yb, Lu) by instrumental neutron activation analysis of the blood of 109 patients with onset of sarcoidosis versus control (28 people) are presented in the article. In blood of patients with sarcoidosis was found low content of Sc, Fe, Co, Zn, Rb (p <0.001), high content of Th (p<0.001), La (p<0.003). There are associations of these elements with the blood formed elements and immune status parameters. No significant correlations between chemical elements and the degree of dyspnea, respiratory functions, radiological disease states, age, frequency of regression or progression, smoking and using drugs were found. High level of lanthanum and hafnium may contribute to the formation of granulomatous reactions in the body. This characteristic may have a local value in the studied region. Influence of these trace elements on the development of sarcoidosis is mediated by action on blood cells and immune processes in the body.

Key words: sarcoidosis, trace elements, neutron activation analysis.

REFERENCES

1. Vizel’ I. Ju., Vizel’ A.A. Rol’ infekcii v patogeneze sarkoidoza // Prakticheskaja medicina. — 2010. — № 40 — S. 14-17.

2. Marshall T.G., Marshall F.E. Sarcoidosis succumbs to antibiotics-implications for autoimmune disease // Autoimmun. Rev. — 2004. — № 3 — P. 295-300.

3. Sarkoidoz: Monografija / pod red. A.A. Vizelja (Serija monografij Rossijskogo respiratornogo obshhestva; gl. red. serii Chuchalin A.G. ). — M.: ATMOSFERA, 2010. — 416 s.

4. Maier L.A. Clinical approach to chronic beryllium disease and other nonpneumoconiotic interstitial lung diseases // J. Thorac Imaging. — 2002. — № 4. — P. 273-284.

5. Denisova O.A. Opyt organizacii medicinskoj pomoshhi bol’nym sarkoidozom v Tomskoj oblasti // Zdravoohranenie Rossijskoj Federacii. — 2012. — № 6 — S. 21-24.

6. Denisova O.A. Soprjazhennost’ soderzhanija mikrojelementov vo vneshnej srede s tireoidnoj patologij zhitelej Tomskoj oblasti // Zdorov’e naselenija i sreda obitanija. — 2007. — № 4. — S. 21-24.

7. Tadzhiev F.S., Kokosov A.N., Il’kovich M.M., Syromjatnikova N.V. Soderzhanie steroidnyh gormonov i mikrojelementov v krovi bol’nyh s disseminirovannymi processami v legkih// Problemy tuberkuleza. — 1989. — № 11. — S. 6-9.

8. Bargagli E., Monaci F., Bianchi N., Bucci C., Rottoli P. Analysis of trace elements in bronchoalveolar lavage of patients with diffuse lung diseases // Biol. Trace Elem. Res. — 2008. — № 124. — P. 225-235.

9. Rihvanov L.P., Jazikov E.G., Baranovskaja N.V., Beljaeva A.M., Zhornjak L.V., Talovskaja A.V., Denisova O.A., Suhih Ju.I. Sostojanie komponentov prirodnoj sredy Tomskoj oblasti po dannym jekologo-geohimicheskogo monitoringa i zdorov’e naselenija // Bezopasnost’ zhiznedejatel’nosti — 2008. — № 1 (85) — S. 29-37.

10. Ghio A.J., Roggli V.L., Kennedy T.P., Piantadosi C.A. Calcium oxalate and iron accumulation in sarcoidosis // Sarcoidosis Vasc. Diffuse Lung Dis. — 2000. — № 17. — P. 140-50.

11. Ju.A. Ershov, V.A. Popkov, Berljand A.Ja. Obshhaja himija. Biofizicheskaja himija. Himija biogennyh jelementov. — M.: Vysshaja shkola, 2003. — 560 s.