D.M. KALILMATOVA, Yu.E. DOBROKHOTOVA

Russian National Research Medical University named after N.I. Pirogov of MOH RF, Moscow

Contact:

Kalimatova D.M. ― PhD (medicine), Associate Professor of the Department of Obstetrics and Gynecology of Therapy Faculty, Chief Doctor of «Health Academy» clinic

Address: 34 Profsoyuznaya Str., apt. 57, Moscow, Russian Federation, tel. +7-926-922-77-07, e-mail: 9227707@gmail.com

The research objective is to analyze literature data on pregnancy features and outcomes in COVID-19 infected women.

General information on the infection epidemiology, characteristics, etiology and pathogenesis of the disease is provided. Information on the current course of pregnancy in COVID-19 infected patients is analyzed. It is noted that the clinical characteristics of pregnant women with confirmed SARS-CoV-2 infection are similar to those in non-pregnant infected women. There is no evidence of vertical transmission of SARS-CoV-2 in late pregnancy. The available data on the features of COVID-19 infection during pregnancy indicate the absence of an increased risk for the mother and fetus.

It is believed that the management of pregnant patients should be individualized on the basis of obstetric indications and the state of maternal/fetal health. It is important to consider that the current COVID-19 pandemic causes psychological stress and anxiety in pregnant women, which may have an adverse effect during pregnancy.

Key words: pregnancy, COVID-19, pregnancy complications, cesarean section, newborns.

REFERENCES

1. Elshafeey F., Magdi R., Hindi N. et al., A systematic scoping review of COVID-19 during pregnancy and childbirth. Int J. Gynaecol. Obstet, 2020. doi: 10.1002/ijgo.13182. [Epub ahead of print]
2. Monteleone P.A., Nakano M., Lazar V. et al. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist. Reprod., 2020, vol. 24 (2), pp. 219-225. doi: 10.5935/1518-0557.20200030.
3. WHO — World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report — 41, 2020a, available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200301-sitrep-41-covid-19.pdf?sfvrsn=6768306d_2
4. Hellewell J., Abbott S., Gimma A. et al. Centre for the Mathematical Modelling of Infectious Diseases C-WG, 2020.
5. Li Q., Guan X., Wu P. et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N. Engl. J. Med, 2020, vol. 382, pp. 1199-207.
6. Zhao S., Lin Q., Ran J. et al. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. Int. J. Infect. Dis, 2020, vol. 92, pp. 214-217.
7. Khan S., Siddique R., Shereen M. et al. The emergence of a novel coronavirus (SARSCoV-2), their biology and therapeutic options. J. Clin. Microbiol, 2020. [Epub ahead of print] DOI: 10.1128/JCM.00187-20
8. Rothe C., Schunk M., Sothmann P. et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N. Engl. J. Med., 2020, vol. 382, pp. 970-971. DOI:10.1056/NEJMc2001468
9. Drosten C., Gunther S., Preiser W. et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med, 2003, vol. 348, pp. 1967-1976.
10. Ksiazek T.G., Erdman D., Goldsmith C.S. et al. SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med., 2003, vol. 348, pp. 1953-1966.
11. Zaki A.M., van Boheemen S., Bestebroer T.M. et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl. J. Med, 2012, vol. 367, pp. 1814-1820.
12. Liu J., Zheng X., Tong Q. et al. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019- nCoV. J. Med. Virol., 2020, vol. 92, pp. 491-494. DOI: 10.1002/jmv.25709
13. Lu R., Zhao X., Li J. et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 2020, vol. 395, pp. 565-574. DOI: 10.1016/S0140-6736(20)30251-8
14. Guo Y.R., Cao Q.D., Hong Z.S. et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak — an update on the status. Mil. Med. Res, 2020, vol. 7, p. 11. DOI:10.1186/s40779-020-00240-0
15. Sun P., Lu X., Xu C. et al. Understanding of COVID-19 based on current evidence. J. Med. Virol, 2020 [Epub ahead of print] DOI:10.1002/jmv.25722
16. Wu Z., McGoogan J.M. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention. JAMA, 2020 [Epub ahead of print] DOI: 10.1001/jama.2020.2648
17. Hui D.S., E I.A., Madani T.A. et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China. Int. J. Infect. Dis, 2020, vol. 91, pp. 264-266. DOI: 10.1016/j.ijid.2020.01.009
18. Jamieson D.J., Theiler R.N., Rasmussen S.A. Emerging infections and pregnancy. Emerg. Infect. Dis, 2006, vol. 12, pp. 1638-1643. DOI: 10.3201/eid1211.060152
19. Goodnight W.H., Soper D.E. Pneumonia in pregnancy. Crit. Care Med, 2005, vol. 33, pp. 390-397.DOI: 10.1097/01.ccm.0000182483.24836.66
20. Wong S.F., Chow K.M., Leung T.N. et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am. J. Obstet. Gynecol, 2004, vol. 191, pp. 292-297. DOI: 10.1016/j. ajog.2003.11.019
21. Jamieson D.J., Honein M.A., Rasmussen S.A. et al. Novel Influenza A (H1N1) Pregnancy Working Group. H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet, 2009, vol. 374, pp. 451-458. DOI: 10.1016/S0140-6736(09)61304-0
22. Schwartz D.A., Graham A.L. Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. Viruses, 2020, vol. 12 (2). pii: E194. DOI:10.3390/v12020194
23. Mehta P., McAuley D.F., Brown M. et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet, 2020, vol. 395, pp. 1033-1034.
24. Mor G., Cardenas I. The immune system in pregnancy: a unique complexity. Am. J. Reprod. Immunol, 2010, vol. 63, pp. 425-433.
25. Chen S., Huang B., Luo D.J. et al. Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases. Zhonghua Bing Li XueZaZhi, 2020, vol. 49: E005. DOI: 10.3760/cma.j.cn112151-20200225-00138
26. Fan C., Lei D., Fang C. et al. Perinatal Transmission of COVID-19 Associated SARS-CoV-2: Should We Worry? Clin. Infect. Dis, 2020, [Epub ahead of print] DOI: 10.1093/cid/ciaa226
27. Liu Y., Chen H., Tang K., Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J. Infect, 2020. [Epub ahead of print] DOI: 10.1016/j.jinf.2020.02.028
28. Wang X., Zhou Z., Zhang J. et al. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin. Infect. Dis. — 2020. [Epub ahead of print] DOI:10.1093/cid/ciaa200
29. WHO — World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). 2020d, available at: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on covid-19-final-report.pdf
30. Wang S., Guo L., Chen L. et al. A case report of neonatal COVID-19 infection in China. Clin. Infect. Dis, 2020, [Epub ahead of print] DOI:10.1093/cid/ciaa225
31. Li N., Han L., Peng M. et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. Clin. Infect. Dis, 2020, [Epub ahead of print].
32. Lowe B., Bopp B. COVID-19 vaginal delivery — a case report. Aust. N. Z. J. Obstet.Gynaecol, 2020. [Epub ahead of print].
33. Zhou R., Chen Y., Lin C. et al. Asymptomatic COVID-19 in pregnant woman with typical chest CT manifestation: a case report. Chin. J. Perinat. Med, 2020, vol. 23. DOI: 10.3760/cma.j.cn113903-20200220-00134.
34. Yao L., Wang J., Zhao J. et al. Asymptomatic COVID-19 infection inpregnant woman in the third trimester: a case report. Chin J. Perinat. Med, 2020, vol. 23. DOI: 10.3760/cma.j.cn113903-2020221-00143.
35. Xiong X., Wei H., Zhang Z. et al. Vaginal Delivery Report of a Healthy Neonate Born to a Convalescent Mother with COVID-19. J. Med. Virol, 2020. [Epub ahead of print].
36. Lee D.H., Lee J., Kim E. et al. Emergency cesarean section on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed patient. Korean J. Anesthesiol, 2020. [Epub ahead of print].
37. Iqbal S.N., Overcash R., Mokhtari N. et al. An Uncomplicated Delivery in a Patient with Covid-19 in the United States. N. Engl. J. Med, 2020, vol. 382 (16):e34.
38. Chen H., Guo J., Wang C. et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 2020, vol. 395, pp. 809-815.
39. RashidiFakari F., Simbar M. Coronavirus Pandemic and Worries during Pregnancy; a Letter to Editor. Arch. Acad. Emerg. Med, 2020, vol. 8: e21. PMID: 32185371