Features of preconception planning of women with violations of carbohydrate exchange and risk of development of gestational diabetes
E.A. GAFAROVA, R.S. ZAMALEYEVA, Ya.E. KOGAN
Kazan State Medical Academy — Branch Campus of the RMACPE MOH Russia, 36 Butlerov Str., Kazan, Russian Federation, 420012
Gafarova E.A. — Cand. Med. Sc., Associate Professor of the Department of Obstetrics and Gynecology No. 1, tel. +7-917-287-44-28, e-mail: lenochkae@list.ru
Zamaleeva R.S. — D. Med. Sc., Professor of the Department of Obstetrics and Gynecology No. 1, tel. +7-919-621-76-51, e-mail: zamaleewa@rambler.ru
Kogan Ya.E. — Cand. Med. Sc., Assistant Lecturer of the Department of Obstetrics and Gynecology No. 1, tel. +7-917-222-75-55, e-mail: yanak@mail.ru
Today we are facing the increasing number of women with different types of carbohydrate exchange disorders, which are planning to become or are pregnant. The new approach to diagnosis of gestational diabetes also leads to the increased incidence of this disease. Deficiency of folates and hyperhomocysteinemia contribute to the development of fetal congenital defects and participate in the development of diabetes and pregnancy complications. Timely and sufficient completion of folate level in pregnant women with violation of carbohydrate exchange at the stage of preconception planning will allow to reduce the frequency of gestational complications and to improve health of women and their posterity.
Key words: diabetes mellitus, gestational diabetes mellitus, insulin resistance, folic acid, hyperhomocysteinemia, preconception planning, folate cycle genes polymorphism, metafloine, fetal congenital defects, pregnancy complications.
REFERENCES
- Tisel’ko A.V. 7th International Symposium «Diabetes, Hypertension, Metabolic Syndrome and Pregnancy», March 13-16, 2013, Florence, Italy. Sakharnyy diabet, 2013, vol. 16b, no. 1, pp. 106–107 (in Russ.).
- Correa A., Gilboa S.M., Botto L.D. at al. Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. Am J Obstet Gynecol, 2012, vol. 206, no. 3, rr. 218–238.
- Leirgul E., Brodwall K., Greve G., Vollset S.E., Holmstrøm H., Tell G.S., Øyen N. Maternal Diabetes, Birth Weight, and Neonatal Risk of Congenital Heart Defects in Norway, 1994–2009. Obstet Gynecol, 2016, vol. 128, no. 5, rr. 1116–1125.
- Radzinskiy V.E. et al. Pregravidarnaya podgotovka: klinicheskiy protocol [Pre-game training: clinical protocol]. Moscow: Redaktsiya zhurnala Status Preasens, 2016. 80 p.
- Kapustin R.V., Arzhanova O.N., Bespalova O.N., Pakin V.S., Kiselev A.G. The role of obesity and excess weight as a factor in the development of gestational diabetes: a systematic review. Zhurnal akusherstva i zhenskikh bolezney, 2015, vol. LXIV, iss. 5, pp. 87–95 (in Russ.).
- Torloni M.R., Betrán A.P., Horta B.L., Nakamura M.U., Atallah A.N., Moron A.F., Valente O. Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis. Obes. Rev, 2009, no. 10, vol. 2, rr. 194–203.
- Nikonova T.V. Kongress ADA 2015 g. v Bostone (SShA) — obzor osnovnykh tem. Sakharnyy diabet, 2015, vol. 18, no. 3, pp. 110–113 (in Russ.).
- Bolotskaya L.L., Esayan R.M., Oleynik O.V. 6th International Symposium «Diabetes and Pregnancy», March 23-26, 2011, Salzburg, Austria. Sakharnyy diabet, 2011, vol. 14, no. 2, pp. 131–132 (in Russ.).
- Dedov I.I., Krasnopol’skiy V.I., Sukhikh G.T. Russian national consensus «Gestational diabetes mellitus: diagnosis, treatment, postnatal observation». Sakharnyy diabet, 2012, vol. 4, pp. 4–10 (in Russ.).
- Klinicheskie rekomendatsii (protokol lecheniya), kollektiv avtorov [Clinical recommendations (protocol of treatment), collective of authors], 2013, Ministerstvo zdravookhraneniya Rossiyskoy Federatsii. 17 p.
- Alison D., Kerry Gernand, Schulze J., Christine Stewart P. et al. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol., 2016, May; 12(5): 274–289.
- Chandrika J. Piyathilake, PLoS One, 2013.
- Knight B.A., Shields B.M., Brook A. et al. Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population. PLoS One, 2015, vol. 19, no. 10(8).
- Shin D., Lee K.W., Song W.O. Pre-Pregnancy Weight Status Is Associated with Diet Quality and Nutritional Biomarkers during Pregnancy. Nutrients, 2016, no. 11;8(3):162. doi: 10.3390/nu8030162.
- Bherwani S., Saumya A.S., Ahirwar A.K. The association of folic acid deficiency and diabetic nephropathy in patients with type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets, 2016, Apr 15. Epub ahead of print.
- Atay A.E., Simsek H., Demir B. et al. Noninvasive assessment of subclinical atherosclerosis in normotensive gravidae with gestational diabetes. Herz, 2014, vol. 39, no. 5, rr. 627–632.
- Tarim E., Bagis T., Kilicdag E., Erkanli S.et al. Elevated plasma homocysteine levels in gestational diabetes mellitus. Acta Obstet Gynecol Scand, 2004, vol. 83, no. 6, rr. 543–547.
- Gong T., Wang J., Yang M. Serum homocysteine level and gestational diabetes mellitus: A meta-analysis. J. Diabetes Investig, 2016, no. 7, vol. 4, rr. 622–628.
- Furness D.L., Yasin N., Dekker G.A. et al. Concentration of folate in erythrocytes of a pregnant woman at the 10th to 12th week of gestation and the outcome of pregnancy. Effektivnaya farmakoterapiya, 2014, no. 45, pp. 44–50 (in Russ.); J. Matern. Fetal. Neonatal. Med. 2012, vol. 25, no. 8, pp. 1423–1427.
- Sinclair K.D. et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci USA, 2007, no. 4, rr. 19351–19356.
- Deshmukh U. et al. Nestle Nutr Inst Workshop, 2013, no. 74, rr. 145–154.
- Iacobazzi V., Infantino V., Castegna A., Andria G. Hyperhomocysteinemia: related genetic diseases and congenital defects, abnormal DNA methylation and newborn screening issues. Mol Genet Metab, 2014, vol. 113, no. 1–2, rr. 27–33.
- Gromova O.A., Serov V.N., Torshin I.Yu., Kerimkulova N.V., Limanova O.A. The role of vitamin-mineral complexes with folic acid in the prevention of congenital heart defects and neural tube defects. Effektivnaya farmakoterapiya, 2015, no. 36, pp. 4–15 (in Russ.).
- Correa A., Gilboa S.M., Botto L.D. Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. Am J Obstet Gynecol, 2012, vol. 206, no. 3, rr. 218–230.
- Kleinwechter H., Demandt N. Diabetes in Pregnancy — Type 1 / Type 2 Diabetes Mellitus and Gestational Diabetes Mellitus. Dtsch Med Wochenschr, 2016, vol. 141, no. 18, rr. 1296–1303.
- Araújo J.R., Correia-Branco A. Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-α. Pediatr Res, 2013, vol. 73, no. 4, rr. 388–394.
- Barbosa P.R., Stabler S.P., Machado A.L. et al. Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. Eur J Clin Nutr, 2008, vol. 62, no. 8, rr. 1010–1021.
- Li X., Jiang J., Xu M. et al. Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate Reductase (MTHFR), Methionine Synthase Reductase (MTRR) Reduced Pregnant Complications. Gynecol Obstet Invest, 2015, no. 79, rr. 107–112.
- Gromova O.A., Serov V.N., Torshin I.Yu., Kerimkulova N.V., Limanova O.A. The role of vitamin-mineral complexes with folic acid in the prevention of congenital heart defects and neural tube defects. Effektivnaya farmakoterapiya, 2015, no. 36, pp. 4–15 (in Russ.).
- Radzinskiy V.E. I et al. Pregravidarnaya podgotovka: klinicheskiy protocol [Preliminary training: clinical protocol]. Moscow: Redaktsiya zhurnala StatusPraesens, 2016. 80 p.
- Gromova O.A., Limanova O.A., Torshin I.Yu. et al. Dosozavisimost protective effects of folic acid in pregravidarny period, during pregnancy and lactation. RMZh, 2014, vol. 22, no. 1, pp. 27–34 (in Russ.).
- Brämswig S., Tobolski O. Prinz-Langenohl R [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C—>T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol, 2009, vol. 158, no. 8, rr. 2014–2021.