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  • Features of neuropathic pain in the affected joints

    Редактор | 2014, Practical medicine 04 (14) Innovative technologies in medicine. Part 1 | 30 июля, 2014

    T.G. SAKOVETS

    Kazan State Medical University, 49 Butlerov St., Kazan, Russian Federation, 420012 

    Sakovets T.G. — Assistant Lecturer of the Department of Neurology and Rehabilitation, tel. (843) 237-34-66, e-mail: tsakovets@yandex.ru

    Joint lesions of various nature are widespread in the population. Though they are the most common cause of disability, there is still no clear understanding of the nature of joint pain. Diseases of the joints can be of independent nosological form or a manifestation of other systems pathology, or a response to a pathological process. Carefully designed studies using experimental models of arthritis and related methodological approaches will clarify all aspects of the formation and mechanisms of neuropathic pain in arthritis, and help to develop an adequate anti-pain therapy.

    Key words: neuropathic pain, joint diseases, joint pain.

     

     

    REFERENCES

    1. Kukushkin M.L., Tabeeva G.R., Podchufarova E.V. Bolevoy sindrom: patogenez, klinika, lechenie: klinicheskie rekomendatsii [Pain syndrome: pathogenesis, clinical features, treatment: clinical guidelines], 2011. 79 p.

    2. Kukushkin M.L. Neurophysiology of pain and pain relief. Bol’, sustavy, pozvonochnik, 2011, no. 2 (in Russ.).

    3. Hildebrand C., Oqvist G., Brax L. et al. Anatomy of the rat knee joint and composition of a major articular nerve. Anat. Rec., 1991, vol. 229, pp. 545-555.

    4. Mach D.B., Rogers S.D., Sabino M.C. et al. Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neurosci., 2002, vol. 113, pp. 155-166.

    5. Heppelmann B., McDougall J.J. Inhibitory effect of amiloride and gadolinium on fine afferent nerves in the rat knee: evidence of mechanogated ion channels in joints. Exp. Brain. Res., 2005, vol. 167, pp. 114-118.

    6. Schuelert N., McDougall J.J. Electrophysiological evidence that the vasoactive intestinal peptide receptor antagonist VIP (6-28) reduces nociception in an animal model of osteoarthritis. Osteoarthritis Cartilage, 2006, vol. 14, pp. 1155-1162.

    7. McDougall J.J., Pawlak M., Hanesch U. et al. Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ. Neurosci. Lett., 2000, vol. 288, pp. 123-126.

    8. http://kpfu.ru/docs/ion channel

    9. Yaksh T.L. Calcium channels as therapeutic targets in neuropathic pain. J. Pain, 2006, vol. 7, rr. 13-S30.

    Метки: joint diseases, joint pain, neuropathic pain, Practical medicine 04 (14) Innovative technologies in medicine. Part 1, T.G. SAKOVETS

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