L.K. RAKHMANOVA, I.A. KARIMDZHANOV, I.R. ISKANDAROVA

Tashkent Medical Academy, Uzbekistan, Tashkent

  Contact details:

Rakhmanova L.K. — MD, Associate Professor of the Department of Children’s Diseases № 2

Address: 2 Farobiy St., Tashkent, Uzbekistan, 100109, tel.: +998-99-850-03-06, e-mail: lola.rahmanova61@mail.ru

With a view to research the clinical and immunological status and production of IL-2 in children with a combined flow of chronic kidney disease (CKD) with lymphatic diathesis (LD) we examined 95 children at the age of 7 to 11 y. o. with chronic kidney disease (nephrotic form). Of them: 35 children with CKD without LD — 1 group; 35 children with CKD and LD — 2 group; 25 children with CKD and LD — 3 group. Control group consisted of 25 actually healthy children of the same age. It was shown that children with a combined flow of chronic kidney disease and LD have worse clinical and laboratory symptoms of CKD, such as: «marble pallor» of skin, oligouria, fatigue, spread swelling, ascites, proteinuria, hypercholesterinemia, hypoalbuminemia, hypergammoglobulinemia and hypercoagulation. Also we revealed increased manifestation of immunodiathesis, including LD, with disfunction in cell and humoral immunity chain: decreased number of T-lymphocytes, T-supressors, T-helpers, FAN; increase of B- lymphocytes, ABL of kidneys, lungs and concentration of CIC. Decreased production of IL-2 with combined flow of LD with CKD and LD alone may be used as an early diagnostic criterion of immunodiathesis and the risk of chronic kidney failure in children with CKD.

Key words: lymphatic diathesis, interleukin-2, kidney.

 (For citation: Rakhmanova L.K., Karimdzhanov I.A., Iskandarova I.R. Features of interleukin-2 production in chronic kidney disease in children with immune diathesis. Practical Medicine. 2019. Vol. 17, № 5, P. 191-194)

REFERENCES

1. K/DOQI: klinicheskie, prakticheskie rekomendatsii po khronicheskomu zabolevaniyu pochek: otsenka, klassifikatsiya i stratifikatsiya [K / DOQI: clinical, practical guidelines for chronic kidney disease: assessment, classification and stratification], available at: http//www.dialysis.uu/standard/doqi-ckd/g7.htm
2. Weening J.J. Advances in the pathology of glomerular diseases. Contrib Nephrol, 2013, vol. 18, pp. 12–21.
3. Makarova Yu.A., Shishkin A.N., Erman M.V. A retrospective assessment of the course of chronic glomerulonephritis, which debuted in childhood. Nefrologiya, 2006, no. 3, pp. 38–42 (in Russ.).
4. Levey A.S., Andreoli S.P., Du Bose P. Chronic kidney disease: common, harmful and treatable — World Kidney Day. Pediatric Nephrology, 2007, vol. 22, pp. 321–325.
5. Smirnov A.V., Dobronravov V.A, Kayukov I.G., Esayan A.M. Chronic kidney disease: further development of the concept and classification. Nefrologiya, 2007, no. 4, pp. 7–18 (in Russ.).
6. Rakhmanova L.K., Iskandarova I.R. Efficiency systemic enzymotherapy in nephrotic syndrome in children with lymphatic diethesis. European Science Review, 2018, vol. 5–6, pp. 183–185.
7. Savenkova N.D., Papayan A.V. Klinicheskaya nefrologiya detskogo vozrasta [Clinical nephrology of childhood]. Saint Petersburg: Pediatricheskiy universitet, 2008. 240 p.
8. Shcherbak V.A, Khamina N.A., Shcherbak N.M. Diathesis and constitutional anomalies in children. Sibirskoe meditsinskoe obrazovanie, 2014, no. 3, pp. 75–79 (in Russ.).
9. Vozgoment O.V. About the role of lymphatic-hypoplastic diathesis in the fatal development of pathological processes in children and the criteria for its diagnosis. Trudnyy patsient, 2014, may (in Russ.), available at: https://cyberleninka.ru
10. Shabalov N.P. Diathesis and constitutional anomalies as a pediatric problem. Pediatriya, 2005, no. 5, pp. 72-76 (in Russ.).
11. Vel’tishchev Yu.E. Stanovlenie i razvitie immunnoy sistemy u detey. Immunnaya nedostatochnost’. Immunodiatezy: lektsiya dlya vrachey [The formation and development of the immune system in children. Immune deficiency Immunodiathesis: a lecture for doctors]. Moscow, 2000.
12. Simbirtsev A.S. Interleukin-2 and the receptor complex of interleukin-2 in the regulation of immunity. Immunologiya, 1998, no. 3, pp. 3–8 (in Russ.).
13. Carrero J.J. Cytokines, atherogenesis and hypercatabolism in chronic kidney disease: a dreadful triad. Semin. Dial, 2009, vol. 22, pp. 381–386.
14. Garib F.Yu. et al. Sposob opredeleniya limfotsitov. Rasmiy akhborotnoma [Method for determining lymphocytes. Rasmus achborotnoma], 1995. no.1. P. 90.
15. Garib F.Yu. et al. Klinicheskaya tsennost’ opredeleniya ASL u bol’nykh bryushnym tifom i drugimi zabolevaniyami. Metod. Rek. [Clinical value of determining ASL in patients with typhoid fever and other diseases. Method. Rec.]. Tashkent, 1983.
16. Bumagina T.K. Determination of the phagocytic activity of neutrophils using latex. Immunologiya, 1981, no. 2, pp. 44–45 (in Russ.).
17. Belokrinitsskiy D.B. Metody klinicheskoy immunologii. V kn: Laboratornye metody issledovaniya v klinike [Methods of clinical immunology. In the book: Laboratory research methods in the clinic]. Moscow: Meditsina, 1987. Pp. 277–310.
18. Aripova T.U., Umarova A.A., Petrova T.A. Normativnye pokazateli osnovnykh parametrov immunnoy sistemy u detey v vozrastnom aspekte: metodicheskie rekomendatsii [Regulatory indicators of the main parameters of the immune system in children in the age aspect: guidelines]. Tashkent, 2004.