E.M. POKROVSKAYA^1, 2, S.V. KHALIULLINA^1, 3, E.F. MANNANOVA^1, 2

 ¹Kazan Federal University, Kazan

²KSMA — Branch Campus of the FSBEI FPE RMACPE MOH, Kazan

³Kazan State Medical University, Kazan

 Contact details:

Pokrovskaya E.M. — MD, Associate Professor, Head of the Department of Otolaryngology and Ophthalmology; Assistant Lecture of the Department of Otolaryngology

Address: 76 Karl Marx St., Kazan, Russian Federation, 420012, tel.: +7-917-263-90-96, e-mail: epokrunia@inbox.r

 The article presents the results of studies of α-defensin level in chronic adenoiditis in children.

The purpose — to assess the state of innate mucosal immunity in chronic adenoiditis.

Material and methods. We examined 151 patients with chronic adenoiditis aged 3 to 7 years. Concentration of α-defensin was determined using the HBT Human HNP 1-3 ELISA kit, designed for the quantification of neutrophil defensins in mixed saliva.

Results. The analysis showed that in both groups of children with chronic adenoiditis there was a statistically significant (p < 0.05) increase in the concentration of defensins in saliva compared to the age norm.

Key words: chronic adenoiditis, mucosal immunity, α-defensins, children.

(For citation: Pokrovskaya E.M., Khaliullina S.V., Mannanova E.F. Features of innate immunity in children with chronic nasopharyngeal infection. Practical medicine. 2023. Vol. , № , P.)

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