А.F. YUSUPOVA, R.KH. GIMAEV

 Ulyanovsk State University, Ulyanovsk

Contact details:

Yusupova A.F. — Senior Lecturer of the Department of Faculty Therapy, post-graduate student

Address: 42 Tolstoy St., 4321017 Ulyanovsk, Russian Federation, tel.: +7-905-035-94-94, e-mail: aigel.yusupova@yandex

Non-alcoholic fatty liver disease (NAFLD) is a pressing issue in modern medicine. NAFLD is particularly relevant in individuals who had an acute myocardial infarction (MI). Several studies indicate that NAFLD directly influences the MI course and the development of its complications, a significant proportion of which are cardiac arrhythmias. Arrhythmogenic complications are caused by disturbances in electrophysiological processes in the myocardium.

The purpose — to evaluate the characteristics of cardiac electrophysiological changes in individuals who had an ST-segment elevation MI (STEMI) associated with NAFLD.

Material and methods. The study included 81 patients who had had an STEMI. They were divided into 2 groups: group 1 (n = 59) — individuals with NAFLD; group 2 (n = 22) — individuals without NAFLD. Electrophysiological parameters of the heart were assessed using standard and high-resolution ECGs on the first day of MI and one month after.

Results. The presence of comorbid NAFLD in individuals on the 1^st day of STEMI was associated with significant differences in QT interval dispersion and the duration of the filtered QRS complex (TotalQRS) of late ventricular potentials. The frequency of late potential recordings did not differ significantly between the comparison groups on the 1^st day of MI. One month after STEMI, individuals with associated NAFLD showed significant differences in P-wave dispersion (dP), QT and JT interval dispersion, as well as a significantly higher frequency of late ventricular potential recordings (55.9 vs. 27.8%, χ² = 4.19; p = 0.04) compared with patients without liver disease.

Conclusion. The presence of NAFLD is associated with the development of more pronounced electrophysiological disturbances of the heart in the 1^st day of STEMI, which worsen during the 1^st month after the infarction.

Key words: non-alcoholic fatty liver disease, myocardial infarction, electrophysiological remodeling, late atrial and ventricular potentials

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