Contact details:

Koynova I.A. — Assistant Lecture of the Department of Hospital and Therapy with a course in rehabilitation, physiotherapy and sports medicine

Address: 2 Moskovskiy trakt, Russian Federation, Tomsk, 634050, tel.: +7-983-233-90-15, e-mail: i.a.tarasova@mail.ru

Development and character of the course of inflammatory bowel disease (IBD) are influenced by associated with a complex of genetic and environmental factors, among which the most studied are vitamin D deficit deficiency, inheritance by hereditary autoimmune diseases, environment, stress, air pollution, smoking, and using of some medications. The purpose was to study the influence of external and internal environment factors on the course of bowels inflammatory diseases inflammatory bowel disease in patients in Tomsk region. Material and methods. The study included 61 patients with ulcerous ulcerative colitis and 63 patients with Crohn’s disease from Tomsk and Tomsk region aged from 18 to 72 y. o.; the diagnosis was confirmed with endoscopic and morphologic methods. The complex of anamnestic and laboratory data was studied,

which are discussed as factors provoking or facilitating the debut and exacerbation of the disease. As a result, it was found that in Tomsk region the external and internal environment factors significantly influence the course of inflammatory bowel disease. The most significant among these factors are urban residence, active smoking, and combination of inflammatory bowel disease with other autoimmune diseases. Psycho-emotional stress had a key significance for developing and progress of the disease in a half of all patients. At that, stress was associated with continuous course, high activity of the disease, and development of hormone dependence. In Crohn’s disease, stress as an exacerbation factor was marked by the patients who were active smokers, for whom the broader bowel inflammation was characteristic. Decrease of vitamin D level in blood serum was to a various extent characteristic for most patients with IBD in Tomsk region and combined with a more severe course of the disease. The obtained results reflect the need for a more detailed study of external and internal environment factors influencing the course of bowels inflammatory diseases inflammatory bowel disease in different regions all over the world.

Key words: inflammatory bowel diseases (IBD), ulcerative colitis (UC), Crohn’s disease (ChD), stress, smoking, vitamin D.

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