S.A. NEDOMOLKINA¹, A.A. PASHKOVA¹, O.V. VELIKAYA¹, T.E. KOTELNIKOVA², A.V. VELIKIY²

 ¹Voronezh State Medical University named after N.N. Burdenko, Voronezh

²«RZhD-Meditsina» Clinical Hospital, Voronezh

 Contact details:

Nedomolkina S.A. — PhD (Medicine), Associate Professor of the Department of Polyclinic Therapy

Address: 10 Studencheskaya St., 394036 Voronezh, Russian Federation, tel.: +7-908-131-73-47, e-mail: svetavel@mail.ru

Anemia is a pathological condition accompanied by a decrease in the concentration of hemoglobin and/or the number of red blood cells per unit volume of blood. According to numerous clinical studies, anemia occurs in 10-80% of patients with cardiovascular pathology (CVP). The significant variability in the incidence of anemia in CVP is explained by the heterogeneity of the anemia causes; varying degrees of severity of cardiovascular diseases and different comorbidity in the subjects. In acute coronary syndrome (ACS), concomitant anemia is considered as an independent predictor of the risk of adverse outcomes and an almost fourfold increase in patient mortality.

The purpose was to study the hemoglobin level in patients with myocardial infarction, who were treated in the Cardiology Department of «RZhD-Meditsina» Clinical Hospital from 2013 to 2023. We selected 224 cardiological case histories, of which 154 were men and 70 women. The average age of the patients was 64.5 ± 11.9 years. Anemia was detected in 60 patients (27%), of which 34 (57%) were women and 26 (43%) men. Anemia of mild severity was detected in 54 (90%) of patients, moderate in 4 (7%), severe in 2 (3%). The etiology of anemia was determined in 33% of cases: 13% had iron deficiency anemia (IDA), 10% anemia of chronic disease (ACD), 7% had posthemorrhagic anemia. Megaloblastic anemia was observed in 3% of patients, without differential diagnosis of the causes. The incidence of anemia in myocardial infarction was 27%, while in women it was 1.3 times more common. Most of the anemias were of mild severity; absolute (AID) and functional (FID) iron deficiency prevailed.

Key words: anemia, CHD, myocardial infarction.

REFERENCES

1. Khamadullina I.F., Khusainova A.A., Ivantsov E.N., Khasanov N.R. Anemia of varying severity in patients with ST-segment elevation myocardial infarction. Vestnik sovremennoy klinicheskoy meditsiny, 2023, vol. 16, iss. 6, pp. 78–81 (in Russ.). DOI: 10.20969/VSKM.2023.16(6).78-81
2. Nedomolkina S.A., Zuykova A.A., Velikaya O.V. Analysis of anemic syndrome in comorbid patients. Sistemnyy analiz i upravlenie v biomeditsinskikh sistemakh, 2022, no. 2, pp. 125–129 (in Russ.).
3. Tarasova N.A., Khasanov N.R. Iron deficiency in patients with cardiovascular diseases. Prakticheskaya meditsina, 2023, vol. 21, no. 2, pp. 15–20 (in Russ.).
4. Guedeney P., Sorrentino S., Claessen B. et al. The link between anemia and adverse outcomes in patients with acute coronary syndrome. Rev. Cardiovasc. Ther, 2019, vol. 17 (3), rr. 151–159.
5. Akhunbaev O.A. The influence of anemia on the course of cardiovascular diseases. ZhKMP, 2023, vol. 1, no. 1, pp. 16–19 (in Russ.).
6. Vinogradova N.G., Chesnikova A.I. Iron deficiency states in cardiovascular diseases: impact on prognosis and features of correction. Yuzhno-Rossiyskiy zhurnal terapevticheskoy praktiki, 2023, vol. 4, no. 1, pp. 7–18 (in Russ.).
7. Farhan S., Baber U., Mehran R. Anemia and acute coronary syndrome: Time for ntervention studies. J. Am. Heart Assoc, 2016, vol. 5 (11), r. e004908.
8. Gorokhovskaya G.N., Martynov A.I., Yun V.L., Petina M.M. Modern view of the therapist on the problem of iron deficiency anemia in patients with cardiovascular pathology. Meditsinskiy sovet, 2020, no. 14, pp. 70–78 (in Russ.).
9. Cai A., Wu Z., Xu L. et al. Association of anaemia and all-cause mortality in patients with ischaemic heart failure varies by renal function status. ESC Heart Fail, 2021, vol. 8 (3), pp. 2270–2281.
10. Lanser L., Fuchs D., Scharnagl H. et al. Anemia of chronic disease in patients with cardiovascular disease. Front. Cardiovasc. Med, 2021, no. 8, r. 666638.
11. Ohana-Sarna-Cahan L., Atar S. Clinical outcomes of patients with acute coronary syndrome and moderate or severe chronic anaemia undergoing coronary angiography or intervention. Eur. Heart. J. Acute. Cardiovasc. Care, 2018, vol. 7 (7), rr. 646–651.
12. Nedomolkina S.A., Zuykova A.A., Velikiy A.V. Anemic syndrome in patients with diabetes mellitus. Terapiya, 2022, no. S4 (56), pp. 89–93 (in Russ.).
13. Khastieva D.R., Khasanov N.R. Iron deficiency in patients with coronary heart disease. Rossiyskiy kardiologicheskiy zhurnal, 2022, vol. 27, no. 4, pp. 49–62 (in Russ.).
14. Huynh R., Hyun K., D’Souza M. et al. Outcomes of anemic patients presenting with acute coronary syndrome: An analysis of the Cooperative National Registry of acute coronary care, guideline adherence and clinical events. Clin. Cardiol, 2019, vol. 42 (9), rr. 791–796.
15. Kurz K., Lanser L., Seifert M. et al. Anemia, iron status, and gender predict the outcome in patients with chronic heart failure. ESC Heart Failure, 2020, no. 7, rr. 1880–1890.
16. Shishkina E.A., Khlynova O.V., Agafonov A.V. Prognostic value of anemia in patients with myocardial infarction of working age. Dnevnik kazanskoy meditsinskoy shkoly, 2020, no. 4, pp. 4–10 (in Russ.).