I.F. FAYRUSHINA^1, 2, E.R. KIRILLOVA^1, 2, D.I. ABDULGANIEVA^1, 2

¹Kazan State Medical University, Kazan

²Republic Clinical Hospital, Kazan

 Contact details:

Fayrushina I.F. — PhD (Medicine), Assistant Lecturer of the Department of Hospital Therapy, rheumatologist, ultrasound specialist

Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-987-186-26-56, e-mail: sirenif@mail.ru

Psoriatic arthritis (PsA) is a chronic progressive disease with heterogeneous clinical manifestations. Fatigue is an important manifestation of PsA.

The purpose — to study the frequency and relationship of fatigue with clinical, laboratory and ultrasound (US) parameters and quality of life in working-age PsA patients.

Material and methods. 92 PsA patients were enrolled to the study. The following data were assessed: demographic, anthropometric, clinical, laboratory and ultrasound. Fatigue was assessed by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire. Severe fatigue was recorded at less than 30 points by FACIT-F. Statistical analysis included descriptive statistics. Correlation analysis was carried out by calculating the Spearman’s correlation coefficient. Comparison between groups was done by Mann-Whitney test. Logistic regression was used to assess the factors influencing fatigue. Differences were considered statistically significant at p < 0.05.

Results. Severe fatigue was found in 30 (27.6%) patients. FACIT-F scores correlated with PsA duration and activity, as well as with clinical enthesitis (p < 0.01). At the same time, fatigue in patients with PsA was not associated with age and anthropometric data, psoriasis (Ps) activity and duration, US signs of entheseal and joint inflammation, laboratory markers and comorbidities (p > 0.05). FACIT-F scores correlated with the level of physical functioning and quality of life (p < 0.01).

Conclusion. Severe fatigue was common in working-age patients with PsA, and its magnitude was closely correlated with DAPSA and was associated with parameters of quality of life and physical functioning, indicating its multifactorial nature. Achieving remission of DAPSA could reduce the severity of fatigue to a certain extent. However, treatment of fatigue associated with PsA should include a multidisciplinary approach in addition to monitoring PsA activity.

Key words: fatigue, psoriatic arthritis, disease activity, quality of life.

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