R.A. FAYZULLINA, U.O. FOMINA, A.V. GALYAUTDINOV, A.M. ZAKIROVA, E.A. SAMORODNOVA

 Kazan State Medical University, Kazan

 Contact details:

Fayzullina R.A. — MD, Professor of the Department of Children’s Diseases Propedeutics and Faculty Pediatrics

Address: 49 Butlerov St., 420012 Kazan, Russian Federation, tel.: +7 (843) 236-06-52, e-mail: rezeda.faizullina@kazangmu.ru

 Over the past century, humanity has made significant breakthroughs in medicine, opening new horizons in the treatment and prevention of various diseases. Obesity among children and adolescents remains one of the major pediatric issues. Delayed diagnosis, prevention, and treatment of childhood obesity can lead to serious health problems in later life, such as diabetes, cardiovascular diseases, musculoskeletal disorders, and, at times, contribute to cognitive impairments and cancers, negatively impacting health and quality of life while shortening lifespan. The roots of childhood obesity lie long before birth. Parental health and nutrition before conception, the health and diet of expectant mothers during pregnancy, and the organization of children’s nutrition after birth — especially in early childhood and adolescence — can program metabolic disorders and obesity in children, along with associated diseases.

Key words: children, adolescents, overweight, obesity, breastfeeding, programming.

REFERENCES

1. Ukaz Prezidenta RF ot 6 iyunya 2019 g. no. 254 “O Strategii razvitiya zdravookhraneniya v Rossiyskoy Federatsii na period do 2025 goda” [Decree of the President of the Russian Federation of June 6, 2019 No. 254 «On the Strategy for the Development of Healthcare in the Russian Federation through 2025»].
2. Zdravookhranenie v Rossii. 2023: Stat. sb. Rosstat []. Moscow, 2023. 179 p.
3. Jebeile H., Kelly A.S., O’Malley G. et al. Obesity in children and adolescents: epidemiology, causes, assessment, and management. Lancet Diabetes Endocrinol, 2022, vol. 10 (5), pp. 351–365. DOI: 10.1016/S22138587(22)00047-X
4. Shoemaker A.H., Chung S.T., Fleischman A. Trends in pediatric obesity management, a survey from the Pediatric Endocrine Society Obesity Committee. J. Pediatr. Endocrinol. Metab, 2020, vol. 33 (4), pp. 469–472. DOI: 10.1515/jpem-2019-054
5. https://www.who.int/ru/news-room/fact-sheets/detail/obesity-and-overweight
6. Gritsinskaya V.L., Novikova V.P., Khavkin A.I. On the epidemiology of obesity in children and adolescents (a systematic review and meta-analysis of scientific publications over a 15-year period). Voprosy prakticheskoy pediatrii, 2022, no. 17 (2), pp. 126–135 (in Russ.). DOI: 10.20953/1817-7646-2022-2-126-135
7. Lobstein T., Jackson-Leach R., Moodie M.L. et al. Child and adolescent obesity: Part of a bigger picture. Lancet, 2015, vol. 20, pp. 2510–2520. DOI: 10.1016/S01406736(14)61746-3
8. Koletzko B., Fishbein M., Lee W.S. et al. Prevention of childhood obesity: a position paper of the Global Federation of International Societies of paediatric gastroenterology, hepatology and nutrition (FISPGHAN). J. Pediatr. Gastroenterol. Nutr, 2020, vol. 70, pp. 702–710. DOI: 10.1097/MPG.0000000000002708
9. Langley-Evans S.C. Nutritional programming of disease: unravelling the mechanism. J. Anat, 2008, vol. 215 (1), pp. 36–51. DOI: 10.1111/j.1469-7580.2008.00977.x
10. Lucas A. Long-term programming effects of early nutrition — implications for the preterm infant. J. Perinatol, 2005, vol. 25 (Suppl 2), pp. S2–6. DOI: 10.1038/sj.jp.7211308
11. Rabadán-Diehl S., Nathanielsz R. From Mice to Men: research models of developmental programming. J. Dev. Orig. Health Dis, 2013, vol. 4 (1), pp. 3–9. DOI: 10.1017/S2040174412000487
12. Chen Y.-P, Xiao X.-M., Li J. et al. Paternal body mass index is associated with offspring intrauterine growth in a gender dependent manner. PLoS One, 2012, vol. 7 (5), p. 36329. DOI: 10.1371/journal.pone.0036329
13. McPherson N.O., Owens J.A., Fullston T., Lane M. Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. Am. J. Physiol. Endocrinol. Metab, 2015, vol. 308 (9), pp. E805–821. DOI: 10.1152/ajpendo.00013.2015
14. Lucas E.S., Watkins A.J. The long-term effects of the periconceptional period on embryo epigenetic profile and phenotype; the paternal role and his contribution, and how males can affect offspring’s phenotype/epigenetic profile. Adv. Exp. Med. Biol, 2017, vol. 1014, pp. 137–154. DOI: 10.1007/978-3-319-62414-3_8
15. Fullston T., Ohlsson-Teague E.M.C., Print C.G. et al. Sperm microRNA content is altered in a mouse model of male obesity, but the same suite of microRNAs are not altered in offspring’s sperm. PLoS One, 2016, vol. 11 (11), e0166076. DOI: 10.1371/journal.pone.0166076
16. Alfaradhi M.Z., Ozanne S.E. Developmental programming in response to maternal overnutrition. Front. Genet, 2011, vol. 2, p. 27. DOI: 10.3389/fgene.2011.00027
17. Sirimi N., Goulis D. Obesity in pregnancy. Hormones, 2010, vol. 9 (4), rr. 299–306. DOI: 10.14310/horm.2002.1280
18. Derraik J.G.B., Ahlsson F., Diderholm B., Lundgren M. Obesity rates in two generations of Swedish women entering pregnancy and associated obesity risk among adult daughters. Sci. Rep, 2015, vol. 5. Article 16692. DOI: 10.1038/srep16692
19. Boney C.M., Verma A., Tucker R., Vohr B.R. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics, 2005, vol. 115 (3), pp. e290–296. DOI: 10.1542/peds.2004-1808
20. Reichman N.E., Nepomnyaschy L. Maternal pre-pregnancy obesity and diagnosis of asthma in offspring at age 3 years. Matern. Child Health J, 2008, vol. 12 (6), pp. 725–33. DOI: 10.1007/s10995-007-0292-2
21. Rodriguez A., Miettunen J., Henriksen T.B. et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int. J. Obes. (Lond), 2008, vol. 32 (3), pp. 550–557. DOI: 10.1038/sj.ijo.0803741
22. Kirk S.L., Samuelsson A.M., Argenton M. et al. Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring. PLoS ONE, 2009, vol. 4 (6), e5870. DOI: 10.1371/journal.pone.0005870
23. Bateson P., Barker D., Clutton-Brock T. et al. Developmental plasticity and human health. Nature, 2004, vol. 430, pp. 419–421. DOI: 10.1038/nature02725
24. Remacle C., Bieswal F., Bol V., Reusens B. Developmental programming of adult obesity and cardiovascular disease in rodents by maternal nutrition imbalance. Am. J. Clin. Nutr, 2011, vol. 94, pp. 1846–1852. DOI: 10.3945/ajcn.110.001651
25. Ozanne S.E., Hales C.N. Lifespan: Catch-up growth and obesity in male mice. Nature, 2004, vol. 427, pp. 411–412. DOI: 10.1038/427411b
26. Ma J., Qiao Y., Zhao P. et al. Breastfeeding and childhood obesity: A 12-country study. Matern. Child Nutr, 2020, vol. 16 (3), e12984. DOI: 10.1111/mcn.12984
27. Jurado L.S., Jiménez Báez M.V., Sibli Olivares Juárez S.O., de la Cruz Olvera T. Breastfeeding, complementary feeding and risk of childhood obesity. Aten. Primaria, 2016, vol. 48 (9), pp. 572–578. DOI: 10.1016/j.aprim.2015.10.004
28. Weber M., Grote V., Closa-Monasterolo R. et al.: Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am. J. Clin. Nutr, 2014, vol. 99, pp. 1041–1051. DOI: 10.3945/ajcn.113.064071
29. Melnik B.C. Excessive leucine-mTORC1-signalling of cow milk-based infant formula: the missing link to understand early childhood obesity. J. Obes. 2012, vol. 2012, p. 197653. DOI: 10.1155/2012/197653
30. Lukushkina E.F., Netrebenko O.K., Baskakova E.Yu. Milk in the nutrition of children and adults: beneficial effects and potential risk. Voprosy sovremennoy pediatrii, 2011, vol. 10, no. 4, pp. 140–144 (in Russ.).
31. Grote V., Theurich M., Koletzko B. Do complementary feeding practices predict the later risk of obesity? Curr. Opin. Clin. Nutr. Metab. Care, 2012, vol. 15 (3), pp. 293–7. DOI: 10.1097/MCO.0b013e328351baba
32. Daniels L., Mallan K.M., Fildes A. et al. The timing of solid intro- duction in an ‘obesogenic’ environment: a narrative review of the evidence and methodological issues. Aust. NZ J. Public Health, 2015, vol. 39, pp. 366–373. DOI: 10.1111/1753-6405.12376
33. Colombo J., Koletzko B., Lampl M. Recent Research in Nutrition and Growth. Nestlé Nutr. Inst. Workshop Ser, vol. 89, pp. 93–103. DOI: 10.1159/000486495.
34. Perkin M.R., Logan K., Tseng A. et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N. Engl. J. Med, 2016, vol. 374, pp. 1733–1743. DOI: 10.1056/NEJMoa1514210
35. Wang J., Wu Y., Xiong G. et al. Introduction of complementary feeding before 4 months of age increases the risk of childhood overweight or obesity: a meta-analysis of prospective cohort studies. Nutr. Res, 2016, vol. 36, pp. 759–770. DOI: 10.1016/j.nutres.2016.03.003
36. Garden F.L., Marks G.B., Simpson J.M., Webb K.L. Body mass index (BMI) trajectories from birth to 11.5 years: Relation to early life food intake. Nutrients, 2012, vol. 4 (10), pp. 1382–1398. DOI: 10.3390/nu4101382
37. Symon B., Crichton G.E., Muhlhausler B. Does the early introduction of solids promote obesity? Singapore Med. J, 2017, vol. 58 (11), pp. 626–631. DOI: 10.11622/smedj.2017024
38. Grote V., Theurich M., Koletzko B. Do complementary feeding practices predict the later risk of obesity? Curr. Opin. Clin. Nutr. Metab. Care, 2012, vol. 15 (3), pp. 293–297. DOI: 10.1097/MCO.0b013e328351baba
39. Pearce J., Langley-Evans S.C. The types of food introduced during complementary feeding and risk of childhood obesity: a systematic review. Int. J. Obes. (Lond), 2013, vol. 37, pp. 4477–4485. DOI: 10.1038/ijo.2013.8
40. Hörnell A., Lagström H., Lande B., Thorsdottir I. Protein intake from 0 to 18 years of age and its relation to health: a systematic literature review for the 5th Nordic Nutrition Recommendations. Food Nutr. Res, 2013, p. 57. DOI: 10.3402/fnr.v57i0.21083
41. Tapeshkina N.V., Perevalov A.Ya. Food preferences of schoolchildren in the Kemerovo region. Voprosy dietologii, 2016, no. 6 (1), pp. 47–53 (in Russ.). DOI: 10.20953/2224-5448-2016-1-47-53
42. Gil’mutdinova R.F. Fast-fud dlya detey: pol’za ili vred? Sbornik statey VIII Mezhdunarodnogo molodezhnogo nauchnogo meditsinskogo foruma “Belye tsvet”, posvyashchennyy 120-letiyu studencheskogo nauchnogo obshchestva imeni I.A. Studentsovoy [Fast food for children: benefit or harm? Collection of articles of the VIII International Youth Scientific Medical Forum «White Flowers», dedicated to the 120th anniversary of the student scientific society named after I.A. Studentsova]. Kazan, 2021. Pp. 742–743.
43. Shavaliev R.F., Fayzullina R.A., Vil’danov I.Kh., Mal’tsev S.V. et al. Health status and commitment to a healthy lifestyle of modern schoolchildren. Voprosy detskoy dietologii, 2018, vol. 16, no. 1, pp. 18–25 (in Russ.).
44. Kondrat’eva E.I., Gorelova Zh.Yu., Ladodo K.S., Prakhin E.I. et al. Results of the implementation of the School Milk program in Russia and Ukraine. Voprosy detskoy dietologii, 2013, vol. 11, no. 1, pp. 69–78 (in Russ.).
45. Auerbach B.J., Wolf F.M., Hikida A. et al. Fruit juice and change in BMI: a meta-analysis. Pediatrics, 2017, vol. 139 (4), e20162454. DOI: 10.1542/peds.2016-2454
46. Pavlovskaya E.V., Lebedeva A.M., Strokova T.V. Nutritional approaches to the prevention of obesity in children. Children’s medicine of the North-West, 2023, vol. 11, no. 3, pp. 76–90 (in Russ.). DOI: https://doi.org/10.56871/CmN-W.2023.86.98.005
47. Svod pravil dlya otsenki kachestva fruktovykh i ovoshchnykh sokov. AIJN (Evropeyskaya assotsiatsiya proizvoditeley fruktovykh sokov). Nekommercheskaya organizatsiya “Rossiyskiy soyuz proizvoditeley sokov” (RSPS) [Code of practice for assessing the quality of fruit and vegetable juices. AIJN (European Association of Fruit Juice Producers)]. Moscow: Planeta, 2019.
48. Khimicheskiy sostav rossiyskikh pishchevykh produktov: spravochnik, pod red. chlen-korr. MAI, prof. I.M. Skurikhina i akad. RAMN, prof. V.A. Tutel’yana [Chemical composition of Russian food products: reference book, edited by Corresponding Member of the MAI, prof. I.M. Skurikhina and acad. RAMS, prof. V.A. Tutelyan]. Moscow: DeLi print, 2002. 236 p.
49. Talaybekov M.T., Madaminova M.A., Bedel’baev S.A., Nurkeev N.B. Sodium glutamate. Impact on human health. Vestnik Kyrgyzsko-Rossiyskogo Slavyanskogo universiteta, 2020, vol. 20, no. 1, pp. 63–67 (in Russ.).
50. Gidding S.S., Lichtenstein A.H., Faith M.S. et al. Council on epidemiology and prevention, and council for high blood pressure research. Circulation, 2009, vol. 119, pp. 1161–1175. DOI: 10.1161/CIRCULATIONAHA.109.191856
51. Rekomendatsii po obshchemu potrebleniyu zhirov dlya predotvrashcheniya nezdorovogo nabora vesa u vzroslykh i detey: kratkoe izlozhenie rukovodstva VOZ [Total fat intake for the prevention of unhealthy weight gain in adults and children: WHO guideline summary], 2023.
52. Chunchai T., Thunapong W., Yasom S. et al. Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats. J. Neuroinflammation, 2018, vol. 15 (1), p. 11. DOI: 10.1186/s12974-018-1055-2
53. Delzenne N.M., Neyrinck A.M., Cani P.D. Gut microbiota and metabolic disorders: How prebiotic can work? Br. J. Nutr, 2013, vol. 109 (suppl 2), pp. 81–85. DOI: 10.1017/S0007114512004047
54. Drapkina O.M., Korneeva O.N. Intestinal microbiota and obesity. Pathogenetic relationships and ways to normalize intestinal microflora. Terapevticheskiy arkhiv, 2016, no. 9, pp. 135–142 (in Russ.). DOI: 10.17116/terarkh2016889135-142
55. Zakharova I.N., Berezhnaya I.V., Simakova M.A. Intestinal microbiota and obesity. Can probiotics help? Pediatriya. Consilium Medicum, 2021, no. 4, pp. 330–334 (in Russ.). DOI: 10.26442/26586630.2021.4.201341
56. Niederer I., Kriemler S., Zahner L. et al. Influence of a lifestyle intervention in preschool children on physiological and psychological parameters (Ballabeina): Study design of a cluster randomized controlled trial. BMC Public Health, 2009, vol. 9, p. 94. DOI: 10.1186/1471-2458-9-94