A.V. KABILOVA¹, G.F. KARIMOVA², L.Sh. NAZAROVA¹, L.N. MINGAZETDINOVA¹, A.B. BAKIROV¹

¹Bashkir State Medical University, 3 Lenin Str., Ufa, Russian Federation, 450008

²City Clinical Hospital No. 13, 28 Nezhinskaya Str., Ufa, Russian Federation, 450112

Contact:

Kabilova A.V. — post-graduate student of the Department of Internal Medicine and Clinical Pharmacology of the Institute for Continuing Professional Education, tel. +7-917-496-47-71, e-mail: kabilovaav@yandex.ru

Karimova G.F. — general practitioner, tel. (347) 264-88-41

Nazarova L.Sh. — Assistant Lecturer of the Department of Internal Medicine and Clinical Pharmacology of the Institute for Continuing Professional Education, tel. (347) 228-95-72, e-mail: lilinaz19@mail.ru

Mingazetdinova L.N. — D. Med. Sc., Professor of the Department of Internal Medicine and Clinical Pharmacology of the Institute for Continuing Professional Education, tel. (347) 228-95-72, e-mail: terklinpharm@bashgmu.ru

Bakirov A.B. — D. Med. Sc., Professor, Head of the Department of Internal Medicine and Clinical Pharmacology of the Institute for Continuing Professional Education, tel. (347) 228-95-72, e-mail: terklinpharm@bashgmu.ru

 The paper presents the results of the investigation of 118 patients with rheumatic diseases, 67 (56.8 %) of them with rheumatoid arthritis, and 51 (43.2 %) with ankylosing spondylitis. The role of the cellular and cytokine components of the immune system was studied in comprehensive assessment with the monocyte chemotoxic factors. The investigation of the immune system included the detection of the peripheral blood lymphocytes subpopulation, neutrophil phagocytic activity, the levels of the concentration of immunoglobulin, proinflammatory cytokines (TNF-α, IL-1β, IL-6), and chemokines (МСР-1, VEGF) using the enzyme immunoassay. C-reactive protein, rheumatoid factor, anticyclic citrullinated peptide, and the histocompatibility antigen HLA were estimated. The correlation between some indicators of phagocytosis, cytokines, and the level of monocyte macrophage factors was observed.

Key words: rheumatoid arthritis, ankylosing spondylitis, immunological indicators, proinflammatory cytokines, chemokines.

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