Khasanova Gulshat Rashatovna — PhD, associated professor of the department of pediatric infectious diseases of Kazan State Medical University, ID specialist of the Center of AIDS and Infectious Diseases of Ministery of Health of Tatarstan Republic, tel. (843) 267-80-06, e-mail: gulshatra@mail.ru^1,2

Stepanova Ekaterina Yurievna — PhD, ID specialist of the Center of AIDS and Infectious Diseases of Ministery of Health of Tatarstan Republic, tel. (843) 238-17-43, e-mail: katyastep@mail.ru²

Mustafin Ilshat Ganievich — D.Med.Sc., professor, head of the department of biochemistry of Kazan State Medical University, head of the Laboratory of clinical immunology of the Center of AIDS and Infectious Diseases of Ministery of Health of Tatarstan Republic, tel. (843) 236-28-89, e-mail: ilshat64@mail.ru^1,2

Erythropoietin synthesis is traditionally considered to be decreased in anemia of chronic disease. The purpose of our research was the evaluation of erythropoietin level in HIV-positive patients with anemia of chronic disease. 98 patients were included (63 — with anemia of chronic disease and 35 — with iron-deficiency anemia). The levels of erythropoietin, proinflammatory cytokines and acute-phase proteins were detected. Strong negative correlations of hemoglobin and erythropoietin were found in both groups: r=-0,8; p=0,00005 in group with iron-deficiency anemia and r=-0,5; p=0,0003 in group with anemia of chronic disease. High levels of proinflammatory cytokines (tumor-necrosis factor-α and interleukin-1β) were presented in both groups, representing the state of chronic immune activation in HIV+patients. Nevertheless higher levels of acute-phase proteins (C-reactive protein and ferritin) and lower level of negative acute-phase protein — transferrin — were detected in group with anemia of chronic disease. Correlations of erythropoietin level with levels of cytokines and acute phase proteins were not found.

Conclusion: adequate response of erythropoietin-producing cells to decrease of hemoglobin level is presented in anemia of chronic disease in HIV-positive patients.

Key words: HIV-infection, anemia, erythropoietin, inflammation.

 

 

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