V.A. LINDE^1, 2, N.YU. KRYLOVA¹, A.S. KALUGINA², A.YU. LYOGONKAYA¹, N.S. KUZ’MINA²

 ¹Municipal Multidisciplinary Hospital No. 2, Saint Petersburg

²Pavlov First Saint Petersburg State Medical University, Saint Petersburg

Contact details:

Lyogonkaya A.Yu. — obstetrician-gynecologist

Address: 5 Uchebniy pereulok, 194354 Saint Petersburg, Russian Federation, tel.: +7-906-959-22-27, e-mail: anzhelika_l_l@mail.ru

The review is based on Cyberleninka, PubMed, MedArt, and CNMB databases. To date, endometrial receptivity appears to be one of the main characteristics that determine the level of fertility in a wide range of gynecologic diseases. For example, infertility associated with uterine myoma, external genital endometriosis, adenomyosis and chronic endometritis is determined, in particular, by the level of endometrial receptivity. At the same time, changes in the endometrium interpreted as manifestations of chronic endometritis are detected to a greater or lesser extent in all the described diseases.

The purpose objective is to facilitate the search for the most effective ways to overcome infertility associated with endometrial receptivity disorder.

Key words: receptivity, fertility, uterine myoma, endometriosis, chronic endometritis.

REFERENCES

1. Practice Committee of the American Society for Reproductive Medicine. Evidence-based reatments for couples with unexplained infertility: a guideline. Fertil. Steril, 2020, vol. 113 (2), pp. 305–322.
2. Guideline Group on Unexplained Infertility; Romualdi D., Ata B., Bhattacharya S., Bosch E., Costello M., Gersak K. et al. Evidence-based guideline: unexplained infertility. Hum. Reprod, 2023, vol. 38 (10), pp. 1881–1890.
3. Bezhenar’ V.F., Linde V.A., Arakelyan B.V. et al. Adenomyosis and fertility: a modern view of the problem (literature review). Zhurnal akusherstva i zhenskikh bolezney, 2022, vol. 71, no. 1, pp. 109–118.
4. Levakov S.A., Budanov P.V., Zayrat’yants O.V. et al. A personalized approach to the management of patients with uterine fibroids. Akusherstvo i ginekologiya, 2019, no. 12, pp. 174–182.
5. Malyshkina D.A., Sotnikova N.Yu., Voronin D.N. et al. Clinical and anamnestic risk factors for the development of uterine leiomyoma in women of reproductive age. Ginekologiya, 2023, vol. 25 (2), pp. 170–176 (in Russ.).
6. Chabbert-Buffet N., Esber N., Bouchard P. Fibroid Growth and medical options for treatment. Fertil. Steril, 2014, vol. 102 (3), pp. 630–639.
7. Abu-Abdallakh M., Artymuk N.V., Surina M.N. Endometrial receptivity. Implantation markers. Fundamental’naya i klinicheskaya meditsina, 2018, vol. 3, no. 3, pp. 71–77 (in Russ.).
8. Ivanov I.I., Gordienko Yu.V., Popova-Petrosyan E.V. et al. Features of the receptor apparatus of simple and proliferating uterine fibroids. Meditsinskiy vestnik Severnogo Kavkaza, 2021, vol. 16, no. 4, pp. 391–395 (in Russ.).
9. Safarova S.M. Morphological characteristics of uterine fibroids among women of reproductive age. Zhurnal akusherstva i zhenskikh bolezney, 2017, vol. 66, no. 1, pp. 27–31 (in Russ.).
10. Doroha O., Iarotskyi M., Iarotska I. et al. Uterine fibroids impact on fertility and pregnancy outcome. EUREKA: Health Sciences, 2020, no. 2, pp. 52–58. DOI: 10.21303/2504-5679.2020.001205
11. Malyshkina A.I., Voronin D.N., Antsiferova Yu.S. et al. Effect of selective progesterone receptor modulator therapy on the synthesis of factors regulating apoptosis and proteolysis in myomatous nodes of patients with large leukomyoma. Akusherstvo i ginekologiya, 2017, no. 2, pp. 64–70 (in Russ.).
12. Adamyan L.V., Andeeva E.N., Absatarova Yu.S. et al. Endometrioz: Klinicheskie rekomendatsii MZ RF; 2020 [Endometriosis: Clinical guidelines of the Ministry of Health of the Russian Federation; 2020]. 32 p.
13. Dunselman G.A., Vermeulen N., Becker C., Calhaz-Jorge C. et al. ESHRE guideline: management of women with endometriosis. Hum. Reprod, 2014, vol. 20, pp. 400–441.
14. Orazov M.R., Radzinskiy V.E., Khamoshina M.B. et al. Infertility associated with endometriosis: from legend to harsh reality. Trudnyy patsient, 2019, vol. 17, no. 1–2, pp. 6–12 (in Russ.).
15. Ponomarenko I.V., Polonikov L.V., Churnosov M.I. Molecular mechanisms and risk factors for the development of endometriosis. Akusherstvo i ginekologiya, 2019, no. 3, pp. 26–31 (in Russ.).
16. Senapati S., Sammel M.D., Morse C., Barnhart K.T. Impact of endometriosis on IVF outcomes: An evaluation of the society for assisted reproductive technologies database. Fertil. Steril, 2016, vol. 106, pp. 164–171.
17. Carvalho L., Podgaec S., Bellodi-Privato M., Falcone T. Role of eutopic endometrium in pelvic endometriosis. J. Minim. Invasive Gynecol, 2011, no. 18, rr. 419–427.
18. Tokushige N., Markham R., Russell P., Fraser I.S. High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis. Hum. Reprod, 2006, vol. 21, pp. 782–787.
19. Bezhenar’ V.F., Linde V.A., Arakelyan B.V. et al. Adenomyosis and fertility: a modern view of the problem (literature review). Zhurnal akusherstva i zhenskikh bolezney, 2022, vol. 71, no. 1, pp. 109–118 (in Russ.).
20. Tong J.L., Lang J.H., Zhu L., Feng R.E. Study of pathological characteristic of eutopic endometrium in endometriosis. Zhonghua Fu Chan Ke Za Zhi, 2012, vol. 47 (11), pp. 829–832.
21. Orazov M.R., Radzinskiĭ V.E., Khamoshina M.B. et al. Efficiency of treatment of infertility caused by recurrent external genital endometriosis. Ginekologiya, vol. 21, no. 1, pp. 38–43 (in Russ.).
22. Lessey B.A., Kim J.J. Endometrial receptivity in the eutopic endo- metrium of women with endometriosis: It is affected, and let me show you why. Fertil. Steril, 2017, vol. 108, pp. 19–27.
23. Kogan E.A., Paramonova N.B., Shklyar A.A. et al. Clinical and morphological features of focal, nodular, and diffuse forms of adenomyosis. Arkhiv akusherstva i ginekologii im. V.F. Snegireva, 2016, vol. 3, no. 1, pp. 18–22 (in Russ.).
24. Adamyan L.V., Andreeva E.N., Absatarova Yu.S. et al. Endometrioz. Kodirovanie po Mezhdunarodnoy statisticheskoy klassifikatsii bolezney i problem, svyazannykh so zdorov’em: N80. Klinicheskie rekomendatsii [Endometriosis. Coding according to the International Statistical Classification of Diseases and Related Health Problems: N80]. Moscow, 2020. 50 p.
25. Gorpenko A.A., Chuprynin V.D., Buralkin N.A. et al. Improving surgical treatment methods for diffuse-nodular adenomyosis. Meditsinskiy sovet, 2019, no. 21, pp. 240–245 (in Russ.).
26. Dobrynina M.L., Batrak N.V., Kryazheva E.O. et al. Features of the application and effectiveness of diagnostic methods for adenomyosis. Vestnik IvGMA, 2020, no. 1, pp. 43–45 (in Russ.).
27. Vannuccini S., Tosti C., Carmona F. et al. Pathogenesis of adenomyosis: an update on molecular mechanisms. Reprod. BioMed. Online, 2017, vol. 35 (5), rr. 592–601.
28. Van Czin., Xiaohui Dan, Yang Yang et al. Expression of Grim-19 in the foci of adenomyosis and its possible role in the pathogenesis of the disease. Fertil. Steril, 2016, vol. 105 (4), pp. 1093–1101.
29. Shang W.Q., Yu J.J., Zhu L. et al. Blocking of IL-22, a potential strategy for the treatment of adenomyosis by inhibiting crosstalk between the vasoendothelial and endometrial stromal cells. Am. J. Transl. Res, 2015, vol. 7 (10), pp. 1782–1797.
30. Dueholm M. Uterine adenomyosis and infertility, review of reproductive outcome after in vitro fertilization and surgery. Acta Obstet. Gynecol. Scand, 2017, vol. 96 (6), rr. 715–726.
31. Maignien C., Santulli P., Gayet V. et al. Prognostic factors for assisted reproductive technology in women with endometriosis-related infertility. Am. J. Obstet. Gynecol, 2017, vol. 216 (280), pp. e1–9.
32. Exacoustos C., Brienza L., Digiovanni A. et al. Adenomiyosis three- dimensional sonographic findings of the junctional zone and correlaion with histology. Ultrasound Obstet. Gynecol, 2011, vol. 37 (4), rr. 471–479.
33. Luciano D.E., Exacoustos C., Albrecht L. et al. Three-dimensional ultrasound in diagnosis of adenomyosis: histologic correlation with ultrasound targeted biopsies of the uterus. J. Minim. Invasive Gynecol, 2013, no. 20, rr. 803–810.
34. Serebrennikova K.G., Arutyunyan N.A., Alekhin A.I. Diagnostics and clinical criteria of chronic endometritis. Ginekologiya, 2018, vol. 20 (6), pp. 53–59 (in Russ.).
35. Tolibova G.Kh., Tral’ T.G. Chronic endometritis — a protracted discussion. Ural’skiy meditsinskiy zhurnal, 2023, vol. 22, no. 2, pp. 142–152 (in Russ.).
36. Chermak I., Chermak V., Matvian M., Singh M. The role of chronic endometritis in development of infertility in terms of etiological factors. Biological update, 2021, vol. 1, pp. 22–27.
37. Motovilova T.M., Kachalina T.S., Anikina T.A. Alternative approach to the treatment of patients with chronic nonspecific endometritis. RMZh. Mat’ i ditya, 2013, no. 14, pp. 751–756 (in Russ.).
38. Aganezova N.V., Aganezov S.S., Gogichashvili K.E. et al. Features of endometrial expression of leukemia-inhibiting factor in women of reproductive age with different endometrial thickness. Problemy reproduktsii, 2023, vol. 29, no. 4, pp. 6–17 (in Russ.).
39. Klimaszyk K., Svarrre Nielsen H. et al. Chronic endometritis — is it time to clarify diagnostic criteria? Ginekol Pol, 2023, vol. 94 (2), pp. 152–157.
40. Mikhnina E.A., Davydova N.I., Kazantsev V.A. et al. Immune response in different morphological forms of chronic endometritis in women with impaired implantation. Akusherstvo i ginekologiya, 2021, no. 12, pp. 110–118 (in Russ.).
41. Ellinidi V.N., Feoktistov A.A., Lyamina A.V. et al. Chronic polypoid or immofollicular endometritis: hysteroscopic and histological diagnostics. Zhurnal akusherstva i zhenskikh bolezney, 2017, vol. 66, no. 6, pp. 59–65 (in Russ.).
42. Burova N.A., Zabolotneva K.O., Abolonina O.V. et al. Restoration of endometrial receptivity in patients with chronic endometritis under the influence of physical factors. Vestnik VolgGMU, 2019, vol. 72, no. 4, pp. 29–32 (in Russ.).
43. Du J., Lu H., Yu X. et al. Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: A protocol for systematic review and meta-analysis. Medicine (Baltimore), 2020, vol. 99 (3), p. e18848.
44. Abu-Abdallakh M., Artymuk N.V., Surina M.N. Endometrial receptivity. Implantation markers. Fundamental’naya i klinicheskaya meditsina, 2018, vol. 3, no. 3, pp. 71–77 (in Russ.).
45. Tolibova G.Kh., Tral’ T.G., Aylamazyan E.K., Kogan I.Yu. Molecular mechanisms of cyclic transformation of the endometrium. Zhurnal akusherstva i zhenskikh bolezney, 2019, vol. 68, no. 1, pp. 5–12 (in Russ.).
46. Holzer I., Ott J., Kurz C., Hofstetter G., Hager M., Kuessel L. et al. Is chronic endometritis associated with tubal infertility? A prospective cohort study. J. Minim. Invasive Gynecol, 2021, vol. 28 (11), pp. 1786–1881.