R.I. GABIDULLINA¹, G.A. SMIRNOVA¹, A.SH. ZARIPOVA¹, E.V. VALEEVA¹, T.N. SHIGABUTDINOVA², L.I. SIRMATOVA²

 ¹Kazan State Medical University, Kazan

²City Clinical Hospital No. 7, Kazan

 Contact details:

Gabidullina R.I. — MD, Professor of the Department of Obstetrics and Gynecology named after V.S. Gruzdev

Address: 49 Butlerov St., Kazan, Russian Federation, 420012, tel.: +7-917-28-99-310, e-mail: ru.gabidullina@yandex.ru

The purpose — to study the current state of the problem of endometrial polyps, to analyze the prevalence of alleles and genotypes of the rs11841589 polymorphism of the KLF12 gene and their association with the risk of endometrial polyps and endometrial cancer in women.

Material and methods. The article presents an overview of publications based on search results in the electronic resources PubMed, Elibrary, EMBASE and Google Scholar. The study included 247 women living in the Republic of Tatarstan: 86 with endometrial polyps (PE), 60 with endometrial cancer (RE), 101 patients without pathological changes in the endometrium. Clinical and laboratory examination, genotyping of the polymorphism rs11841589 of the KLF12 gene, pathomorphological examination of the endometrium were carried out. The biomaterial for genotyping the polymorphism rs11841589 of the KLF12 gene was DNA from whole blood (TestGen, Ulyanovsk). A set of reagents «Rapid-Genetics Test» by DNA-Technology LLC (Moscow, Russia) was used. The study was carried out within the framework of KSMU research No. 122082300042-2 in compliance with the principles and conditions of the Helsinki Declaration.

Results. Endometrial polyps, due to their prevalence, high frequency of abnormal uterine bleeding and the risk of malignancy, represent one of the most serious gynecological problems worldwide. The mutant allele with the rs11841589 polymorphism of the KLF12 gene and the CC genotype, according to the study, do not significantly increase the risk of developing endometrial polyps and endometrial cancer in women living in the Republic of Tatarstan. It is proved that the prevalence of alleles and genotypes is comparable to the European population.

Conclusion. This study showed that 247 residents of the Republic of Tatarstan included in the study had no association of rs11841589 polymorphism of the KLF12 gene with the risk of developing endometrial polyps and endometrial cancer.

Key words: endometrial polyp, endometrial cancer, KLF12 gene, single nucleotide polymorphism.

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