P.V. LYSKIN, V.D. ZAKHAROV, M.I. ZGOBA

The S. Fyodorov Eye Microsurgery Federal State Institution, 59а Beskudnikovskiy blvd, Moscow, Russian Federation, 127486

 Lyskin P.V. — Cand. Med. Sc., ophthalmo-surgeon of the Department of Vitreoretinal Surgery and Eye Diabetes, tel. (499) 488-89-26, e-mail: plyskin@yahoo.com

Zakharov V.D. — D. Med. Sc., Professor, Head of the Department of Vitreoretinal Surgery and Eye Diabetes, tel. (499) 488-85-53, e-mail: fgu@mntk.ru

Zgoba M.I. — postgraduate student of the Department of Vitreoretinal Surgery and Eye Diabetes, e-mail: zgobami@gmail.com

The aim of the study was to evaluate the dynamics of changes in the concentration of serum cytokines tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-8 (IL-8), interleukin-1β, interleukin-8, interleukin-6 after vitreoretinal surgery and correlation between the increase in the concentration of cytokines studied and the total laser energy produced by endolaser photocoagulation. The study is based on the analysis of changes in blood serum after vitreoretinal operations and involved 172 patients. The patients of the first group were treated for rhegmatogenous retinal detachment with endolaser photocoagulation. They were divided into 3 subgroups depending on the total energy used for endolaser photocoagulation. Control groups were formed in order to compare the indicators of immunology research, laser correction was not performed in them. The degree of inflammatory reaction was evaluated by the changes in concentration of TNF-α, IL-1β, IL-8, IL-6 and IL-10 in blood serum. The largest increase in the concentration of IL-1β and IL-8 inflammation markers was found in the group with the intraoperative ELC of 3-4 row and more, which corresponds to 986±178 coagulates and the total laser energy of 451.9±126.2 J. Direct correlation was found between the total energy of endolaser photocoagulation and the increase in the concentration of IL-1β, IL-8 in the blood of the patients of the study group. This proves the positive correlation of these factors. The excessive burn component of the endolaser photocoagulation of the retina may be one of the risk factors for the development of a postoperative inflammatory reaction.

Key words: regmatogenous retinal detachment, endolaser photocoagulation, interleukin-10, interleukin-8, interleukin-1β, interleukin-6. tumor necrosis factor α.

REFERENCES

1. Kolechenkova I.V. Modern views on the pathogenesis of uveitis. Rossiyskaya detskaya oftal’mologiya, 2014, no. 4, p. 42 (in Russ.).
2. Metelitsyna I.P., Levitskaya G.V., Gaffari Sakhbi Ben Mokhamed Monsef. Cytokine blood profile in patients with rheumatogenic retinal detachment with a different clinical picture. Ukraїns’kiy medichniy al’manakh, 2011, vol. 14, no. 3, pp. 119-121 (in Russ.).
3. Tikhonovich M.V., Lyskin P.V., Ioyleva E.E., Davydova M.P., Gavrilova S.A. Expression of growth, trophic and proinflammatory factors in epiretinal membranes of patients with severe form of proliferative vitreoretinopathy. Oftal’mokhirurgiya, 2015, no. 4, pp. 36-42 (in Russ.).
4. Khodzhaev N.S., Chernykh V.V., Kuntysheva K.E. Clinico-pathogenetic and prognostic significance of the factors of the progression of diabetic retinopathy against the background of hypertonic disease after phacoemulsification. Oftal’mokhirurgiya, 2015, no. 3, pp. 37-42 (in Russ.).
5. Chernykh D.V., Smirnov E.V., Gorbenko O.M., Shvayuk A.P., Obukhova O.O., Trunova L.A., Chernykh V.V., Trunov A.N. Disturbances of cytokine regulation in the pathogenesis of proliferative diabetic retinopathy. Oftal’mokhirurgiya, 2015, no. 2, pp. 50-54 (in Russ.).
6. Heo M.S., Kim H.W., Lee J.E. et al. The clinical features of macular pucker formation after pars plana vitrectomy for primary rhegmatogenous retinal detachment repair. Korean J Ophthalmol, 2012, Oct, vol. 26(5), rr. 355-61.
7. Kiss C.G., Richter-Müksch S. et al. Anatomy and function of the macula after surgery for retinal detachment complicated by proliferative vitreoretinopathy. American Journal of Ophthalmology, 2007 Dec, vol. 144(6), rr. 872-877.
8. Kunikata H., Abe T., Nishida K. Successful outcomes of 25- and 23-gauge vitrectomies for giant retinal tear detachments. Ophthalmic Surg Lasers Imaging, 2011, Nov-Dec, vol. 42(6), rr. 487-92.
9. Martínez-Castillo V., Boixadera A., Distéfano L. et al. Epiretinal membrane after pars plana vitrectomy for primary pseudophakic or aphakic rhegmatogenous retinal detachment: incidence and outcomes. Retina, 2012, Jul, vol. 32(7), rr. 1350-5.
10. Silva D.J., Kwan A., Bunce C., Bainbridge J. Predicting visual outcome following retinectomy for retinal detachment. British Journal of Ophthalmology, 2008, Jul., vol. 92(7), rr. 954-8.
11. Shaimova V.A. The role of proinflammatory cytokines in eye diseases (review of literature). Oftal’mokhirurgiya i terapiya, 2004, vol. 4, no. 3, pp. 30-32 (in Russ.).
12. Dehne M.G., Sablotzki A., Hoffmann A. et al. Alterations of acute phase reaction and cytokine production in patients following severe burn injury. Burns, 2002, vol. 28(6), rr. 535-542.
13. Paulus Y.M., Kuo C.H., Morohoshi K. et al. Serum inflammatory markers after rupture retinal laser injury in mice. Ophthalmic Surg Lasers Imaging Retina, 2015, Mar., 46(3), rr. 362-8.
14. Poya Tababat-Khani, Lisa M. Berglund, Carl-David Agardh et al. Photocoagulation of Human Retinal Pigment Epithelial Cells In Vitro: Evaluation of Necrosis, Apoptosis, Cell Migration, Cell Proliferation and Expression of Tissue Repairing and Cytoprotective Genes PLoS One, 2013, 8(8), e70465.