O.N. ZAJNULLINA¹, D.V. PECHKUROV², Z.R. HISMATULLINA¹

 ¹Bashkir State Medical University, Ufa

²Samara State Medical University, Samara

 Contact details:

Zajnullina O.N. — MD, Associate Professor of the Department of Dermatovenereology

Address: 6 Stolbovaya St., 450018 Ufa, Russian Federation, tel.: +7-917-79-36-442, e-mail: olisenok@mail.ru

 The article presents a literature review on the relationship between skin diseases and the microbiological landscape and metabolic activity of the intestinal microbiota. Microbial imbalance and intestinal barrier disorders negatively affect the skin structure and function, which is confirmed by skin manifestations during exacerbation of intestinal diseases. The metabolic function of the intestinal microbiota is reflected by changes in the concentration of short-chain fatty acids (SCFA) in feces. Their synthesis is one of the main factors of colonization resistance, ensuring the intestinal microflora constancy. The authors discuss the correlation between the clinical form of acne and the severity of dysbiotic disorders in the intestine. Stimulating the development and growth of own microflora and restoring its metabolic activity is considered to be a promising method for correcting dysbiotic disorders in the intestine. The clinical observation demonstrates that bacteriological and biochemical studies of feces in patients with severe recurrent acne are needed in order to optimize therapy.

Key words: acne, intestinal microbiome, short-chain fatty acids, prebiotic, enterosorbent.

REFERENCES

1. O’Neill C.A., Monteleone G., McLaughlin J.T., Paus R. The gut-skin axis in health and disease: a paradigm with therapeutic implications. Bioessays, 2016, vol. 38, pp. 1167–1176. DOI: 10.1002/bies.201600008
2. Wesemann D.R., Nagler C.R. The microbiome, timing, and barrier function in the context of allergic disease. Immunity, 2016, vol. 44, pp. 728–738. DOI: 10.1016/j.immuni.2016.02.002
3. Pechkurov D.V., Zaynullina O.N., Tyazheva A.A., Lyamin A.V. A new approach to assessing and correcting intestinal biocenosis disorders in children with atopic dermatitis. Nauka i innovatsii v meditsine, 2019, vol. 4, no. 1, pp. 53–57 (in Russ.).
4. Maguire M., Maguire G. The role of microbiota, and probiotics and prebiotics in skin health. Arch. Dermatol. Res, 2017, vol. 309 (6), pp. 411–421. DOI: 10.1007/s00403-017-1750-3
5. Abdurakhmanov M.M., Azizov B.S., Akramova N.Sh. Intestinal microbiocenosis and immune dysfunction in acne pathogenesis (review). Zhurnal teoreticheskoy i klinicheskoy meditsiny, 2021, no. 2, pp. 145–149 (in Russ.).
6. Jeong J.H., Lee C.Y., Chung D.K. Probiotic lactic acid bacteria and skin health. Crit. Rev. Food Sci. Nutr, 2016, vol. 56 (14), pp. 2331–2337. DOI: 10.1080/10408398.2013.834874
7. Purchiaroni F., Tortora A., Gabrielli M. et al. The role of intestinal microbiota and the immune system. Europ. Rev. Med. Pharmacol. Sci, 2013, vol. 17 (3), pp. 323–333.
8. Arzikulov A.Sh., Abdumukhtarova M.Z. Modern concepts of short-chain fatty acids and their role in the development of the gastrointestinal tract. Novyy den’ v meditsine, 2021, vol. 2, no. 34, pp. 506–510 (in Russ.).
9. Peng K., Xia S., Xiao S., Yu Q. Short-chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: A promising therapy? J Gastroenterol Hepatol, 2022, vol. 37 (9), rr. 1710–1718. DOI: 10.1111/jgh.15970
10. Ardatskaya M.D. Microbiota, short-chain fatty acids and their importance for intestinal function. Effektivnaya farmakoterapiya, 2019, vol. 15, no. 2, pp. 88–90 (in Russ.).
11. Matosova E.V., Bynina M.P., Shekhovtsova O.A. et al. Short-chain fatty acids as signaling molecules of intestinal microflora biofilms. Bakteriologiya, 2022, vol. 7, no. 3, p. 50 (in Russ.).
12. Bokova T.A., Ardatskaya M.D. Features of the functional state and intestinal microbiocenosis in children with metabolic syndrome. Eksperimental’naya i klinicheskaya gastroenterologiya, 2013, no. 1, pp. 34–37 (in Russ.).
13. Minushkin O.N., Maslovskiy L.V., Ardatskaya M.D. et al. Clinical and metabolic effects of metaprebiotic therapy for some functional bowel diseases. Eksperimental’naya i klinicheskaya gastroenterologiya, 2021, vol. 10, no. 194, pp. 100–108 (in Russ.). DOI: 10.31146/1682-8658-ecg-194-10-100-108
14. Zaynullina O.N., Pechkurov D.V., Lyamin A.V., Khismatullina Z.R. Characteristics of the microbiome of the main biotopes in children with atopic dermatitis. Pediatriya. Zhurnal im. G.N. Speranskogo, 2020, vol. 99, no. 2, pp. 74–80 (in Russ.). DOI: 10.24110/0031-403X-2020-99-2-74-80
15. Kruglova L.S., Petriy M.N., Gensler E.M. Intestinal microbiota: role in the development of atopic dermatitis and methods of therapy for its violation. Meditsinskiy alfavit, 2020, no. 6, pp. 22–26 (in Russ.).
16. Mukhacheva D.A., Raznatovskiy K.I., Sobolev A.V. The role of neurotransmitters and intestinal microbiota in the pathogenesis of atopic dermatitis. Klinicheskaya dermatologiya i venerologiya, 2023, vol. 22, no. 3, pp. 302–308 (in Russ.). DOI: 10.17116/klinderma202322031302
17. Onishchenko N.S., Kasatkina N.M. Features of skin and intestinal microbiocenoses in parasitic invasion in patients with eczema. Sovremennye problemy nauki i obrazovaniya, 2012, no. 6, p. 580 (in Russ.).
18. Goncharov A.A., Dolgikh O.V. Immunological and genetic features of the pathogenetic association of psoriasis and colon dysbiosis. Infektsiya i immunitet, 2021, vol. 11, no. 2, pp. 237–248 (in Russ.). DOI: 10.15789/2220-7619-IAG-1277
19. Batkaev E.A., Maglaperidze M.G., Tadzhibaev U.A. et al. Efficiency of correction of disturbed microbiocenosis in treatment of psoriasis. Vestnik poslediplomnogo meditsinskogo obrazovaniya, 2023, no. 3, pp. 11–20 (in Russ.).
20. Zaynullina O.N., Khismatullina Z.R., Khayretdinova T.B. Features of treatment of intestinal dysbiosis in adolescents with acne. Meditsinskiy vestnik Bashkortostana, 2013, vol. 8, no. 1, pp. 49–53 (in Russ.).
21. Oudenhoven M.D., Kinney M.A., McShane D.B. et al. Adverse effects of acne medications: recognition and management. Amer. J. Clin. Dermatol, 2015, vol. 16 (4), rr. 231–242. DOI: 10.1007/s40257-015-0127-7
22. Andreeva E.N., Sheremet’eva E.V., Grigoryan O.R., Absatarova Yu.S. Acne — a disease of civilization. Problemy reproduktsii, 2020, vol. 26, no. 1, pp. 6–12 (in Russ.).
23. Shakirova A.T., Koybagarova A.A., Kichina T.V., Golyaeva K.S. Excoriated acne and psychoemotional states. Evraziyskiy soyuz uchenykh, 2020, no. 10-3 (79), pp. 53–55 (in Russ.).
24. Bogatova I.D., Biryukova N.V. Acne on the skin in adolescence. Tendentsii razvitiya nauki i obrazovaniya, 2021, no. 74-1, pp. 20–22 (in Russ.).
25. Olisova O.Yu. Modern aspects of acne treatment. Effektivnaya farmakoterapiya, 2022, vol. 18, no. 39, pp. 6–8 (in Russ.).
26. Vasil’eva E.S., Belyakina N.O. The role of dysbiotic disorders in the pathogenesis of acne. Voenno-meditsinskiy zhurnal, 2008, no. 7, p. 23 (in Russ.).
27. Primak T.D. Microbial associations in acne in adults. Bakteriologiya, 2017, vol. 2, no. 3, p. 95 (in Russ.).
28. Ledentsova S.S., Gulyaev N.I., Oreshko L.S., Seliverstov P.V. Changes in the microbiome in patients with acne and celiac disease with various treatment methods. Eksperimental’naya i klinicheskaya gastroenterologiya, 2022, no. 11 (207), pp. 70–79 (in Russ.).
29. Ursova N.I. Narusheniya mikroflory i disfunktsii biliarnogo trakta u detey. Rukovodstvo dlya praktikuyushchikh vrachey [Microflora disorders and biliary tract dysfunctions in children. A guide for practicing physicians]. Moscow: Ratiofarm, 2005. 218 p.
30. Groeger D., O’Mahony L., Murphy E.F. et al. Bifidobacterium infantis 35 624 modulates host inflammatory processes beyond the gut. Gut Microbes, 2013, vol. 4 (4), rr. 325–339. DOI: 10.4161/gmic.25487
31. Kolodkin A.M., Ardatskaya M.D. Study of the content of short-chain fatty acids in feces of children with functional gastrointestinal disorders under the influence of a metaprebiotic. University Ther. J, 2023, vol. 5, no. S, pp. 98–99 (in Russ.).
32. Yan R., Murphy M., Genoni A. et al. Does Fibre-fix provided to people with irritable bowel syndrome who are consuming a low FODMAP diet improve their gut health, gut microbiome, sleep and mental health? A double-blinded, randomised controlled trial. BMJ Open Gastroenterol, 2020, vol.7 (1), p. e000448. DOI: 10.1136/bmjgast-2020-000448